Anti-Antibody Activity of a Monoclonal Macroglobulin

Abstract

A monoclonal macroglobulin from a patient with Waldenstrom macroglobulinemia has been shown to have antiglobulin activity of a new type, namely, that of a true anti-antibody. The protein reacts with human, primate, and rabbit IgM and IgG,-only when the target immunoglobulin is complexed to an antigen. The implications of the general findings of antiglobulin activity of monoclonal proteins is discussed in relation to the possible etiology of the disease.

Polyclonal Human Antibodies to IgG (Rheumatoid Factors) Which Cross‐React with Cell Nuclei

“…Alternatively, the binding of both Hgands tn the same antibodies could be due to multispecificity of individual Ig molecules. Amonm yeloma proteins there are several examples of apparent multiple specificity (11, 13, 18), including monoclonal immunoglobulins with RF activity which have been observed to react with denatured DNA (7), nitrophenyl haptens (7,8,19), and a streptococcal peptidoglycan (3). Polyclonal immunoglobulins with both RF and antinitrophenyl activity have also been reported (8).…”

Dietary Changes in Temporal Relation to Multiple Sclerosis in the Faroe Islands: An Evaluation of Literary Sources

“…dinitrophenol and trinitrophenol, as known from basic immunologic research, e.g. their ability to break self-toler ance by modifying self-determinants [63,64], to react with MHC products thus indue-ing an antiautologous class II T-cell response with subsequent polyclonal B-cell activation [65,66], to induce the formation of anti bodies whose idiotypes cross-react with (mu rine) class II antigens [67], to cross-react per se with human IgG epitopes [68,69], and to obscure the difference between self and for eign class I [70,71 ] and class II [72] antigens, a contributory role of such agents in the gen eration of autoimmune responses should not be excluded. Since smoke from coniferous wood is rich in compounds of the guaiacol type [58,59], having a free 6-position, nitrophenol formation might be more extended when coniferous wood is used for smoking.…”

Monoclonal immunoglobulins in patients with carcinoma of the colon

“…It has been established, mainly on a structural basis, that these proteins represent homogeneous populations of molecules within the generally heterogeneous immunoglobulins of a normal individual [8]. Many monoclonal immunoglobulins have been shown to have antigen-binding activities [23], including binding specificities for gamma globulins [17,18,36], red blood cell antigens of the Ii series (i.e., cold agglutinins) [7,10], rubella virus [33], alpha-2-mac. roglobulin [28], lipoprotein [3], streptolysin [39], phosphorylcholine [6], other bacterial antigens [6], nucleic acid derivatives [27], and a variety of haptens, such as dinitrophenol [2,9].…”