Anti-anxiety activity of Eucalyptus tereticornis n-hexane extract in Wistar albino rats

Manikkoth, Shyamjith; Damodar, Sheeba; Sequeira, Melinda; Kevin, Samuel

doi:10.18203/2319-2003.ijbcp20170816

Cited by 4 publications

(2 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They include stress, alcohol and substance abuse, and drug-induced and genetic abnormalities. Generalized anxiety disorder, panic disorders with or without agoraphobia, social phobia, obsessivecompulsive disorder, and post-traumatic stress disorder are examples of different types of anxiety disorders 6 . Anxiety disorders are the most prevalent psychiatric disorders and a leading cause of disability 7 .…”

Section: Introductionmentioning

confidence: 99%

Untitled

2023

IJPSR

View full text Add to dashboard Cite

Anxiety is a negative emotional state marked by tension, unease, and emotions of concern and fear. Across the globe, women are more likely than males to suffer from anxiety disorders. Insomnia, cold or sweaty hands and/or feet, shortness of breath, an inability to be steady and calm, dry mouth, numbness or tingling in the hands or feet, nausea, abdominal discomfort, dizziness, pins and needles, feelings of losing control, heart palpitations, pins, and needles are just a few symptoms of anxiety disorders. Many systems indicate that when someone is anxious, they exhibit a variety of cognitive, physiological, and behavioral symptoms. Anxiety is brought on by aberrant chemoreceptor responsiveness and unusual neurochemical behavior. Many neurotransmitters, including gamma-amino butyric acid, serotonin, dopamine, noradrenaline (norepinephrine), glutamate, and others, are involved in anxiety. Some have an excitatory or an inhibitory effect. Several promising medications that may be helpful in the treatment of anxiety disorders have been identified via research in the field of herbal pharmacology. Unfortunately, there hasn't been a thorough examination of plant-based anxiolytics that focuses on their mode of action. Thus, our goal was to present a thorough narrative evaluation of plantbased medications with preclinical evidence of anxiolytic action.

show abstract

Section: Introductionmentioning

confidence: 99%

Untitled

2023

IJPSR

View full text Add to dashboard Cite

show abstract

“…In light/dark transition model, animal spent more time in dark chamber than in light chamber due to fear for facing new environmental condition 28. Parameters such as; number of entries into light chamber and time spent in light chamber are assessed for the evaluation of antianxiety property 29. The ethanolic leaf extract of Tinospora cordifolia at a dose of 100, 200, 400mg/kg was given orally to mice of respective groups for 7 days.…”

mentioning

confidence: 99%

Evaluation of Anti-anxiety Potential of Tinospora cordifolia (Willd.) Leaf Extract in Mice Using Experimental Models

Mp¹,

M²,

Joshi³

2022

JYP

View full text Add to dashboard Cite

Objectives: The present study was conducted to evaluate the anxiolytic potential of ethanolic leaf extract of Tinospora cordifolia Linn. Tinospora cordifolia, the versatile herbal drug is the distinctive source of constituents which is having antidiabetic, immunomodulatory, antioxidant, antimicrobial, antitoxic and anticancer activity. Methods: Leaves of Tinospora cordifolia was collected, dried and powdered used for 7 days cold maceration process. Ethanolic extract was subjected to the preliminary phytochemical screening to analyse the presence of active constituents. At a dose of 100mg/kg, 200mg/kg, 400mg/kg body weight of animal was evaluated for antianxiety activity in mice using 3 experimental designs; elevated plus maze, open filed, light/dark transition model. Test group animals were compared with group of animal treated with diazepam (1mg/kg) as standard drug. Ethanolic extract at 100, 200, and 400mg/kg showed activity in dose dependent manner and at a dose of 400mg/kg showed significant increase; in elevated plus maze, number of entries in open arm and time spent in open arm; number of entries into light chamber and time spent in light chamber in light and dark transition model and in open field; number of square crossed, number of rearing and time spent in central square. Results: The results supported traditional use of Tinospora cordifolia in nervous disorders. Conclusion: Study concluded that ethanolic extract of leaves of Tinospora cordifolia at a dose of 400mg/kg has significant antianxiety activity.

show abstract