Anti-anxiety activity of successive extracts of angelica archangelica linn. on the elevated t-maze and forced swimming tests in rats

Kumar, Dinesh; Bhat, Zulfiqar Ali; Shah, M. Y.

doi:10.1016/s0254-6272(13)60049-7

Cited by 17 publications

(14 citation statements)

References 8 publications

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“…9 This can be employed in physiological 10,11,12 , natural, 17 environmental, 13,14 nutritional, 21,25 or pathological models. 15,16,18,19,20,22,23,24,26 Memory and learning experiments form a large portion of those undertaken and evaluated by psychologists, although they comprise a subset of yet-underdetermined and bizarre cognitive processes. Memory has been extensively studied and its neurological base has been known, though less determinatively.…”

Section: Discussionmentioning

confidence: 99%

Rationality and Novelty of Instrumental Use in Neuropsychological Research Evaluations: Taking Infinity to Singularity - A Meta-Analysis

Narayanan¹

2014

3rd Annual International Conference on Cognitive and Behavioral Psychology (CBP 2014)

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Background: Few studies address the rationality of utilization of instrumental tasking and maze learning in neuropsychological research evaluations; this is apparent from the literature search in biomedical databases with appropriate keywords yielding nil hits for rationality of such usage. Furthermore, how could such rationality be interpreted and used for scientific benefits of the researcher? What is the scope of applicability of such research in neuropsychology to patient care? This systematic review addresses such key issues and focuses on ways to appraise such research articles using rationality as the key criterion in such appraisals and interpretations.Objectives & scope: The systematic review focuses on deciphering the rationality and novelty of instrumental usage in neuropsychological research and patient care, from a thorough literature search in a seven month period from January 2013 to July 2013 in the "medline" database. The review was a pilot initiative to give a recommended harmonized validated checklist to best search, select, appraise, and apply such research for two purposespsychological research and patient care.Methods: To this end, this meta-analysis uses "medline" index and "pubmed" database to establish a list of the pre-clinical and clinical research articles using instrumental tasks and maze learning in the last seven months. Then, quantitative analysis of these included articles are performed using MS Excel 2013 with Daniel XL-add in. Qualitative analysis of the selected articles has been performed using a pilot checklist validation, provided in this article; the same can be used for appraising and applying such research to the benefits of researcher and patients. The last seven months has been chosen appropriately since this is a pilot attempt to fulfilling the objective that it intends to do so.Conclusions & limitations: This meta-analysis will be useful in giving recommendation about how to select and critically appraise and interpret such neuropsychological evaluations in research using maze and neurological instrumentation. The study has not considered in-depth the methodologies of each individual research study. Although novelty was one of the objectives, it could not be met with appropriately due to the diverse nature of methodologies followed in each of the included research articles. Nonetheless, this pilot meta-analysis must encourage more explorations in this research area from a broader perspective in the future.

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Section: Discussionmentioning

confidence: 99%

Rationality and Novelty of Instrumental Use in Neuropsychological Research Evaluations: Taking Infinity to Singularity - A Meta-Analysis

Narayanan¹

2014

3rd Annual International Conference on Cognitive and Behavioral Psychology (CBP 2014)

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“…A mouse was considered to be immobile when it remained floating in the water without struggling, making only minimum movements of its limbs necessary to keep its head above water. The total duration of immobility was recorded during the next 4 min of a total 6-min test [ 10 ]. The changes in immobility duration were studied after administering drugs in separate groups of animals.…”

Section: Methodsmentioning

confidence: 99%

Ergosteryl 2-naphthoate, An Ergosterol Derivative, Exhibits Antidepressant Effects Mediated by the Modification of GABAergic and Glutamatergic Systems

Zhu

Zhao

et al. 2017

Molecules

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Phytosterols are a kind of natural component including sitosterol, campesterol, avenasterol, ergosterol (Er) and others. Their main natural sources are vegetable oils and their processed products, followed by grains, by-products of cereals and nuts, and small amounts of fruits, vegetables and mushrooms. In this study, three new Er monoester derivatives were obtained from the reflux reaction with Er: organic acids (furoic acid, salicylic acid and 2-naphthoic acid), 1-Ethylethyl-3-(3-dimethyllaminopropyl) carbodiimide hydrochloride (EDCI) and 4-dimethylaminopyridine (DMAP) in dichloromethane. Their chemical structures were defined by IR and NMR. The present study was also undertaken to investigate the antidepressant-like effects of Er and its derivatives in male adult mice models of depression, and their probable involvement of GABAergic and glutamatergic systems by the forced swim test (FST). The results indicated that Er and its derivatives display antidepressant effects. Moreover, one derivative of Er, ergosteryl 2-naphthoate (ErN), exhibited stronger antidepressant activity in vivo compared to Er. Acute administration of ErN (5 mg/kg, i.p.) and a combination of ErN (0.5 mg/kg, i.p.), reboxetine (2.5 mg/kg, i.p.), and tianeptine (15 mg/kg, i.p.) reduced the immobility time in the FST. Pretreatment with bicuculline (a competitive γ-aminobutyric acid (GABA) antagonist, 4 mg/kg, i.p.) and N-methyl-d-aspartic acid (NMDA, an agonist at the glutamate site, 75 mg/kg, i.p.) effectively reversed the antidepressant-like effect of ErN (5 mg/kg, i.p.). However, prazosin (a α1-adrenoceptor antagonist, 1 mg/kg, i.p.) and haloperidol (a non-selective D2 receptor antagonist, 0.2 mg/kg, i.p.) did not eliminate the reduced immobility time. Altogether, these results indicated that ErN produced antidepressant-like activity, which might be mediated by GABAergic and glutamatergic systems.

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“…Flavonoids, organic acids, steroids, saponins, alkaloids, simple sugars and fats are also present in the raw material [9]. It can effectively regulate digestive system, stimulate immune system and improve resistance of the nervous system in anxiety and dementia [10][11][12][13]. It also exhibits bactericidal, fungicidal and anti-inflammatory effects [14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Variability of composition of essential oil and coumarin compounds of Angelica archangelica L.

Forycka

Buchwald

2019

Herba Polonica

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SummaryThe medicinal and culinary properties of Angelica archangelica L. have been known and valued since the Middle Ages. Ingredients of essential oil and coumarins found in this plant are to a large degree responsible for its pharmacological activity. This study is a review of the literature of the most important biologically active compounds present in herbal raw materials: root (rhizome with roots) and angelica fruits. Research shows that the content of individual compounds of the essential oil and coumarin fraction is variable, which may point to a large intraspecific variation. Therefore, these compounds may be good markers for identifying taxa or chemotypes in chemotaxonomic research valuable for the herbal medicine and pharmaceutical industry.

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Anti-anxiety activity of successive extracts of angelica archangelica linn. on the elevated t-maze and forced swimming tests in rats

Cited by 17 publications

References 8 publications

Rationality and Novelty of Instrumental Use in Neuropsychological Research Evaluations: Taking Infinity to Singularity - A Meta-Analysis

Rationality and Novelty of Instrumental Use in Neuropsychological Research Evaluations: Taking Infinity to Singularity - A Meta-Analysis

Ergosteryl 2-naphthoate, An Ergosterol Derivative, Exhibits Antidepressant Effects Mediated by the Modification of GABAergic and Glutamatergic Systems

Variability of composition of essential oil and coumarin compounds of Angelica archangelica L.

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