Anti-apoptotic and anti-inflammatory effects of naringin on cisplatin-induced renal injury in the rat

Chtourou, Yassine; Aouey, Bakhta; Aroui, Sonia; Kebieche, Mohamed; Fetoui, Hamadi

doi:10.1016/j.cbi.2015.11.019

Cited by 89 publications

(49 citation statements)

References 58 publications

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“…It has been reported that these reactive species act directly on cell components, including lipids, proteins, and DNA causing their modification leading to cellular dysfunction and apoptosis . The depletion of antioxidant defense components such as SOD, catalase, and GSH further increases the susceptibility to oxidative/nitrosative stress . In agreement with previous studies , our study confirmed that high dose cisplatin administration leads to oxidative/nitrosative stress as evident from the significant increase in MDA and nitrite along with the significant decrease in endogenous antioxidants.…”

Section: Discussionsupporting

confidence: 91%

“…Morin hydrate (100 mg/kg) supplementation significantly attenuated cisplatin‐induced formation of MDA, nitrite as well as a decrease in GSH, antioxidant levels in both kidney and liver. The protection offered by morin hydrate against oxidative/nitrosative stress might be attributed to its intrinsic antioxidant activity owing to the hydroxyl groups attached at various positions in its characteristic bioflavonoid structure , enabling it to directly scavenge the reactive species and/or enhance the transcriptional upregulation of antioxidant genes .…”

Section: Discussionmentioning

confidence: 99%

“…Flavonoids are promising compounds, with their universal presence in almost all dietary plants, fruits, vegetable, nuts, and seeds as well as most types of tea and red wine . Recently, preclinical and clinical studies on supplementation of flavonoids, such as naringin and quercetin , have demonstrated beneficial role in attenuating cisplatin‐induced nephrotoxicity. Morin hydrate (3,5,7,2′,4′‐pentahydroxyflavone) is a flavonoid found in the mill ( Prunus dulcis ) and fig ( Chlorophora tinctora ), (Moraceae), which are used as herbal medicines .…”

Section: Introductionmentioning

confidence: 99%

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Morin Hydrate Mitigates Cisplatin‐Induced Renal and Hepatic Injury by Impeding Oxidative/Nitrosative Stress and Inflammation in Mice

Athira

Madhana

Kasala

et al. 2016

J Biochem & Molecular Tox

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Cisplatin is a widely used chemotherapeutic drug; however, it induces damage on kidney and liver at clinically effective higher doses. Morin hydrate possesses antioxidant, anti-inflammatory, and anticancer properties. Therefore, we aimed to investigate the effects of morin hydrate (50 and 100 mg/kg, orally) against the renohepatic toxicity induced by a high dose of cisplatin (20 mg/kg, intraperitoneally). Renal and hepatic function, oxidative/nitrosative stress, and inflammatory markers along with histopathology were evaluated. Morin hydrate ameliorated cisplatin-induced renohepatic toxicity significantly at 100 mg/kg as evidenced from the significant reversal of cisplatin-induced body weight loss, mortality, functional and structural alterations of kidney, and liver. The protective role offered by morin hydrate against cisplatin-induced renohepatic toxicity is by virtue of its free radical scavenging property, thereby abating the depletion of cellular antioxidant defense components and through modulation of inflammatory cytokines. We speculate morin hydrate as a protective candidate against renohepatic toxicity of cisplatin.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Morin Hydrate Mitigates Cisplatin‐Induced Renal and Hepatic Injury by Impeding Oxidative/Nitrosative Stress and Inflammation in Mice

Athira

Madhana

Kasala

et al. 2016

J Biochem & Molecular Tox

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“…It may be inferred that NRG protects glomerular and interstitial capillary vessels to prevent kidney dysfunction. It is estimated that NRG administration either eliminates ROS directly, or decreases ROS levels by transcriptional up‐regulation of antioxidant genes (Chtourou et al, ; Jeon et al, ).…”

Section: Discussionmentioning

confidence: 99%

“…The protective effects of SLY could be related to its antioxidant properties, because it was shown to be a ROS eliminator and inhibitor of lipid peroxidation (El-Shitany et al, 2008). NRG also protected against kidney damage caused by gentamicin and cisplatin (Chtourou, Aouey, Aroui, Kebieche, & Fetoui, 2016;Sahu et al, 2014). It may be inferred that NRG protects glomerular and interstitial capillary vessels to prevent kidney dysfunction.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic effects of silymarin and naringin on methotrexate-induced nephrotoxicity in rats: Biochemical evaluation of anti-inflammatory, antiapoptotic, and antiautophagic properties

et al. 2017

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Silymarin (SLY) and naringin (NRG) are natural flavonoids that have been reported to have many benefits and medicinal properties. The present study was designed to investigate the protective effect of SLY and NRG against methotrexate (MTX)‐induced nephrotoxicity in experimental animals. Rats were subjected to oral pretreatment of SLY (25 and 50 mg/kg body weight (b.w.)/day) and NRG (50 and 100 mg/kg b.w./day) for 7 days against renal toxicity induced by single intraperitoneal administration of MTX (20 mg/kg b.w.). MTX resulted in an increase in serum toxicity markers, lipid peroxidation, and reduction in activities of antioxidant enzymes. Additionally, MTX provoked inflammatory responses by increasing the levels of TNF‐α, IL‐1β, IL‐6, NF‐κB, and activation of COX‐2 and iNOS. Furthermore, MTX administration caused apoptosis and autophagy by increasing activity of Caspase‐3 and light chain 3B level. Conversely, SLY and NRG therapy significantly decreased these values in rats. This study demonstrated that SLY and NRG protect against MTX‐induced nephrotoxicity. Practical applications Chemotherapeutic drugs have been used for cancer treatment for many years. However, in the treatment process, they may damage organs such as liver and kidney, prolong the treatment process and negatively affects patient welfare. This study revealed that silymarin and naringin exhibited potent anti‐inflammatory, antiapoptotic, and antiautophagic effect in renal injury caused by methotrexate, a chemotherapeutic drug. Therefore, treatment silymarin and naringin can be used for the beneficial effect against methotrexate‐induced kidney damage in cancer chemotherapy.

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Thymoquinone has a neuroprotective effect against inflammation, oxidative stress, and endoplasmic reticulum stress in the brain cortex, medulla, and hippocampus due to doxorubicin

Kaymak

Akın

Öztürk

et al. 2021

J Biochem & Molecular Tox

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Although doxorubicin (DOX) is used in many cancer treatments, it causes neurotoxicity. In this study, the effect of thymoquinone (THQ), a powerful antioxidant, on DOX-induced neurotoxicity was evaluated. In total, 40 rats were used and 5 groups were formed. Group I: control group (n = 8); Group II: olive oil group (n = 8); Group III: the THQ group (n = 8); THQ 10 mg/kg per day was given intraperitoneally (i.p.) throughout the experiment; group IV: DOX group (n = 8); On Day 7 of the experiment, a single dose of 15 mg/kg intraperitoneally DOX injected; group V: DOX + THQ group (n = 8); Throughout the experiment, 10 mg/kg THQ per day and intraperitoneally 15 mg/kg DOX on Day 7 were injected. Immunohistochemically, tumor necrosis factor-α (TNF-α), interleukin-17 (IL-17), hypoxia-inducible factor 1α (HIF1-α), glucose regulatory protein 78 (GRP78), and the gene inducible by growth arrest and DNA damage 153 (GADD153) proteins were evaluated in the brain cortex, medulla, and hippocampus regions. Total oxidant status (TOS) levels and total antioxidant status (TAS) in the brain tissue were measured. TNF-α, IL-17, HIF1-α, GRP78, and GADD153 immunoreactivities significantly increased in the DOX group in the study. THQ significantly reduced these values. THQ increased the TAS level significantly and decreased the TOS level significantly compared to the DOX group.THQ may play a role as a neuroprotective agent in DOX-induced neurotoxicity in the cortex, medulla, and hippocampus regions of the brain.

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Anti-apoptotic and anti-inflammatory effects of naringin on cisplatin-induced renal injury in the rat

Cited by 89 publications

References 58 publications

Morin Hydrate Mitigates Cisplatin‐Induced Renal and Hepatic Injury by Impeding Oxidative/Nitrosative Stress and Inflammation in Mice

Morin Hydrate Mitigates Cisplatin‐Induced Renal and Hepatic Injury by Impeding Oxidative/Nitrosative Stress and Inflammation in Mice

Therapeutic effects of silymarin and naringin on methotrexate-induced nephrotoxicity in rats: Biochemical evaluation of anti-inflammatory, antiapoptotic, and antiautophagic properties

Thymoquinone has a neuroprotective effect against inflammation, oxidative stress, and endoplasmic reticulum stress in the brain cortex, medulla, and hippocampus due to doxorubicin

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