Anti-apoptotic and Anti-oxidative Roles of Quercetin After Traumatic Brain Injury

Yang, Tao; Kong, Bin; J, Gu; Kuang, Yongqin; Cheng, Lin; Yang, Wentao; Xia, Xun; Shu, Hai-Feng

doi:10.1007/s10571-014-0070-9

Cited by 89 publications

(56 citation statements)

References 29 publications

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“…As reported, quercetin inhibits hydrogen peroxide-induced apoptosis in mesangial cells [34] and epithelial cells [35]. Quercetin was also known to inhibit apoptosis of neuronal cells caused by trauma brain injury [36]. However, quercetin frequently activates apoptosis in cancer cells.…”

Section: Discussionmentioning

confidence: 99%

Quercetin induces apoptosis and cell cycle arrest in triple-negative breast cancer cells through modulation of Foxo3a activity

Nguyen

Lee

Sharma

et al. 2017

Korean J Physiol Pharmacol

139

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Quercetin, a plant-derived flavonoid found in fruits, vegetables and tea, has been known to possess bioactive properties such as anti-oxidant, anti-inflammatory and anti-cancer. In this study, anti-cancer effect of quercetin and its underlying mechanisms in triple-negative breast cancer cells was investigated. MTT assay showed that quercetin reduced breast cancer cell viability in a time and dose dependent manner. For this, quercetin not only increased cell apoptosis but also inhibited cell cycle progression. Moreover, quercetin increased FasL mRNA expression and p51, p21 and GADD45 signaling activities. We also observed that quercetin induced protein level, transcriptional activity and nuclear translocation of Foxo3a. Knockdown of Foxo3a caused significant reduction in the effect of quercetin on cell apoptosis and cell cycle arrest. In addition, treatment of JNK inhibitor (SP 600125) abolished quercetin-stimulated Foxo3a activity, suggesting JNK as a possible upstream signaling in regulation of Foxo3a activity. Knockdown of Foxo3a and inhibition of JNK activity reduced the signaling activities of p53, p21 and GADD45, triggered by quercetin. Taken together, our study suggests that quercetin induces apoptosis and cell cycle arrest via modification of Foxo3a signaling in triple-negative breast cancer cells.

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Section: Discussionmentioning

confidence: 99%

Quercetin induces apoptosis and cell cycle arrest in triple-negative breast cancer cells through modulation of Foxo3a activity

Nguyen

Lee

Sharma

et al. 2017

Korean J Physiol Pharmacol

139

View full text Add to dashboard Cite

show abstract

“…Nevertheless, there is also evidence that quercetin metabolites reach the cerebrospinal fluid after peripheral treatment [65–67]. Quercetin also induces neuroprotective effects via inhibition of oxidative stress and inflammation in a traumatic brain injury model was also demonstrated [68]. Considering the information described above, local actions of quercetin in the spinal cord could not be disproved.…”

Section: Discussionmentioning

confidence: 99%

Quercetin Inhibits Peripheral and Spinal Cord Nociceptive Mechanisms to Reduce Intense Acute Swimming-Induced Muscle Pain in Mice

et al. 2016

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The present study aimed to evaluate the effects of the flavonoid quercetin (3,3´,4´,5,7-pentahydroxyflavone) in a mice model of intense acute swimming-induced muscle pain, which resembles delayed onset muscle soreness. Quercetin intraperitoneal (i.p.) treatment dose-dependently reduced muscle mechanical hyperalgesia. Quercetin inhibited myeloperoxidase (MPO) and N-acetyl-β-D- glucosaminidase (NAG) activities, cytokine production, oxidative stress, cyclooxygenase-2 (COX-2) and gp91phox mRNA expression and muscle injury (creatinine kinase [CK] blood levels and myoblast determination protein [MyoD] mRNA expression) as well as inhibited NFκB activation and induced Nrf2 and HO-1 mRNA expression in the soleus muscle. Beyond inhibiting those peripheral effects, quercetin also inhibited spinal cord cytokine production, oxidative stress and glial cells activation (glial fibrillary acidic protein [GFAP] and ionized calcium-binding adapter molecule 1 [Iba-1] mRNA expression). Concluding, the present data demonstrate that quercetin is a potential molecule for the treatment of muscle pain conditions related to unaccustomed exercise.

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“…Studies have investigated Quercetin as an antioxidant3949, anti-angiogenic5051, neuroprotective5253, and anti-apoptotic agent5455. In ocular studies, Quercetin has been found to be efficacious in cataract prevention56, retinal angiogenesis57, and oxidative damage in retinal pigment epithelium cells5859.…”

Section: Discussionmentioning

confidence: 99%

Quercetin Attenuates Lactate Production and Extracellular Matrix Secretion in Keratoconus

McKay

Lyon

Sarker-Nag

et al. 2015

Sci Rep

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Keratoconus(KC) is an ecstatic corneal disease leading to corneal-thinning and the formation of a cone-like cornea. Elevated lactate levels, increased oxidative stress, and myofibroblast formation have all been previously reported. In the current study, we assess the role of Quercetin on collagen secretion and myofibroblast formation in KC in vitro. Human corneal fibroblasts(HCFs) and human keratoconus cells(HKCs) were treated with a stable Vitamin C derivative and cultured for 4 weeks, stimulating formation of a self-assembled extracellular matrix. All samples were analyzed using Western blots and targeted tandem mass spectrometry. Our data showed that Quercetin significantly down regulates myofibroblast differentiation and fibrotic markers, such as α-smooth muscle actin (α-SMA) and Collagen III (Col III), in both HCFs and HKCs. Collagen III secretion was reduced 80% in both HCFs and HKCs following Quercetin treatment. Furthermore, Quercetin reduced lactate production by HKCs to normal HCF levels. Quercetin down regulated TGF-βR2 and TGF-β2 expression in HKCs suggesting a significant link to the TGF-β pathway. These results assert that Quercetin is a key regulator of fibrotic markers and ECM assembly by modulating cellular metabolism and TGF-β signaling. Our study suggests that Quercetin is a potential therapeutic for treatment of corneal dystrophies, such as KC.

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Anti-apoptotic and Anti-oxidative Roles of Quercetin After Traumatic Brain Injury

Cited by 89 publications

References 29 publications

Quercetin induces apoptosis and cell cycle arrest in triple-negative breast cancer cells through modulation of Foxo3a activity

Quercetin induces apoptosis and cell cycle arrest in triple-negative breast cancer cells through modulation of Foxo3a activity

Quercetin Inhibits Peripheral and Spinal Cord Nociceptive Mechanisms to Reduce Intense Acute Swimming-Induced Muscle Pain in Mice

Quercetin Attenuates Lactate Production and Extracellular Matrix Secretion in Keratoconus

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