Anti-arrhythmic profile of a garlic dialysate assayed in dogs and isolated atrial preparations

Martín, N.; Bardisa, L.; Pantoja, C.; Vargas, Marisol; Quezada, Patricia; Valenzuela, Javier Vidal

doi:10.1016/0378-8741(94)90109-0

Cited by 35 publications

(27 citation statements)

References 18 publications

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“…Several reports (25)(26)(27) have indicated that allicin is the predominant active component that is responsible for the majority of the biological activities of garlic, including attenuating ischemic injury, lowering blood pressure and antiarrhythmic effects (6,28,29). The chemical structure of allicin is CH 2 =CH-CH 2 -S(O)-S-CH 2 -CH=CH 2 , and it has been has been manufactured synthetically and produced worldwide (18).…”

Section: Discussionmentioning

confidence: 99%

“…Martín et al (18) revealed that allicin inhibited the myocardial contraction and slowed the sinus rhythm. In a further study, Martín et al (19) demonstrated that garlic dialysate was able to prolong the effective refractory period and the sinus node recovery time of isolated rat atria, in addition to suppressing premature ventricular contractions and ventricular tachycardia in ouabain-intoxicated canines.…”

Section: Introductionmentioning

confidence: 99%

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Allicin inhibits transient outward potassium currents in mouse ventricular myocytes

Cao

Huang

Wang

2016

Experimental and Therapeutic Medicine

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Abstract. Allicin is the active constituent of garlic, a widely used spice and food. The remedial properties of garlic have also been extensively researched and it has been demonstrated that allicin is able to inhibit the transient outward potassium current (I to ) in atrial myocytes. However, the direct effect of allicin on I to in ventricular myocytes has yet to be elucidated. In the present study, the effects of allicin on I to in ventricular myocytes isolated from mice were investigated, using the whole-cell patch recording technique. The results revealed that I to current was not significantly suppressed by allicin in the low-dose group (10 µmol/l; P>0.05). However, I to was significantly inhibited by higher doses of allicin (30, 100 and 300 µmol/l; P<0.05 vs. control; n=6) in a concentration-dependent manner (IC 50 =41.6 µmol/l). In addition, a high concentration of allicin (≥100 µmol/l) was able to accelerate the voltage-dependent inactivation of I to in mouse ventricular myocytes. In conclusion, the present study revealed that allicin inhibited the I to in mouse ventricular myocytes, which may be the mechanism through which allicin exerts its antiarrhythmic effect.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Allicin inhibits transient outward potassium currents in mouse ventricular myocytes

Cao

Huang

Wang

2016

Experimental and Therapeutic Medicine

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“…In 1994, the antiarrhythmic activities of garlic extract were reported in live animals and an atrial tissue preparation [11]. In the first arm, dogs were anesthetized and ouabain was administered at 40% to 50% of the lethal dose to induce ventricular arrhythmias (premature ventricular contractions [PVCs] in 55% and VT in 45%).…”

Section: Evidence For Antiarrhythmic Efficacy Of Herbal Medicationsmentioning

confidence: 99%

Herbal medicine: Beneficial effects, side effects, and promising new research in the treatment of arrhythmias

Stout

Weinstock²,

Homoud³

et al. 2003

Curr Cardiol Rep

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Herbal medications and dietary supplements are unregulated in the United States. The use of these medications has dramatically increased over the past decade. Many of these drugs are biologically active, yet physicians are often unaware their patients are using a traditional remedy. Physicians are frequently unfamiliar with the medications being used and the intended effect, as well as the side-effect profiles that accompany them. Recently, some of the herbal mediations that are commonly used in the general population have been shown to be beneficial for the treatment of arrhythmias. Unfortunately, many more have been shown to be detrimental. In this article, the background behind herbal medication and the degree to which herbal medications are being used is reviewed. Herbal medications known to have beneficial effects in the treatment of arrhythmias, as well as those that have known detrimental effects with regard to cardiac arrhythmias, are highlighted. Finally, research that has been done in this field, focusing on those compounds that have been shown to be biologically active in the treatment of cardiac arrhythmias, are reviewed.

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“…También se ha demostrado en perros su efecto antiarrítmico dosis-dependiente por la supresión de contracciones ventriculares precoces, así como de la incidencia de taquicardia ventricular (14). Por otra parte se ha contrastado en modelos animales los efectos diuréticos de cápsulas de ajo en polvo y de su efecto antihipertensivo, provocando, a dosis elevadas, bradicardia e inversión de la onda T en el ECG (15).…”

Section: Efecto Sobre La Tensión Arterial Y Endotelio Vascularunclassified

Ajo y riesgo cardiovascular

Luis

Aller

2008

An. Med. Interna (Madrid)

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INTRODUCCIÓNEl ajo Allium sativum, perteneciente a la familia botánica de las liliáceas forma parte del género Allium, al que pertenecen la cebolla, los puerros o ciboulette. Su olor, penetrante y persistente, constituye su característica más notable. Esta planta es una hierba perenne resistente de 20 a 40 centímetros de altura, hojas alargadas, y flores blancas o rosadas, presenta un bulbo o "cabeza", compuesto por bulbillos o "dientes", dispuestos alrededor del tallo y envueltos en una membrana suave y sedosa.El ajo es el más picante de todos los Allium y ha sido ampliamente utilizado en muchas culturas para finalidades medicinales y culinarias, estando ampliamente introducido en nuestra dieta mediterránea. El ajo es una de las plantas curativas más antiguas de la que tenemos referencia, ha sido cultivado por los seres humanos como planta de alimento desde hace más de 10.000 años. El ajo nace en el antiguo Turkestán (límite entre China y Afganistán e Irán) desde donde es exportado a China, India, norte de Europa y las márgenes del Mediterráneo. El Codex Ebres, un papiro médico que data del 1550 a. C. contiene 22 menciones sobre el ajo y su aplicación en el control de cardiopatía, mordeduras parásitos intestinales y tumores. Los principales componentes activos del ajo son los amino- [0212-7199 (2008) RESUMENEl ajo es una de las plantas curativas más antiguas de la que tenemos referencia. En el presente trabajo, revisaremos las evidencias existentes sobre el consumo de ajo y el riesgo cardiovascular, analizando su papel sobre el perfil lipídico, el endotelio vascular y la agregación plaquetaria. El consumo regular de 5 g de ajo crudo dos veces al día durante 42 días disminuye los niveles de colesterol total y triglicéridos, no obstante la mayor parte de los estudios realizados en el campo de os lípidos han sido llevados a cabo en animales. En modelos animales (perros y ratas) se ha demostrado los efectos hipotensores del ajo de manera dosis dependiente. Algunos trabajos han demostrado que el ajo activa la fibrinolisis, además de suprimir el sistema de coagulación previniendo así la formación de trombos. Estos resultados se han corroborado en otro trabajo, en el cual se demuestra que el extracto alcohólico de ajo es un potente inhibidor de la agregación plaquetaria.En resumen, los efectos del ajo sobre la disminución del riesgo cardiovascular son importantes. No obstante los estudios en humanos son escasos y todavía falta por demostrar que estos efectos disminuyan los eventos cardiovasculares así como la cantidad necesaria de ajo para obtener estos beneficios.

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Anti-arrhythmic profile of a garlic dialysate assayed in dogs and isolated atrial preparations

Cited by 35 publications

References 18 publications

Allicin inhibits transient outward potassium currents in mouse ventricular myocytes

Allicin inhibits transient outward potassium currents in mouse ventricular myocytes

Herbal medicine: Beneficial effects, side effects, and promising new research in the treatment of arrhythmias

Ajo y riesgo cardiovascular

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