Anti-arthritic activity of 11-O-(4′-O-methyl galloyl)-bergenin and Crassula capitella extract in rats

El‐Hawary, Seham S.; Mohammed, Rabab; AbouZid, Sameh; Ali, Z; Elwekeel, Ahlam

doi:10.1111/jphp.12566

Cited by 21 publications

(8 citation statements)

References 42 publications

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“…Bergenin is a bioactive compound derived from many medicinal plants. Bergenin shows hepatoprotective ( Xiang et al., 2020 ), antioxidant ( Zhang et al., 2022a ), anti-arthritic ( El-Hawary et al., 2016 ), antidiabetic ( Kumar et al., 2012 ), anticancer ( Shi et al., 2021 ), and antiviral activity ( Tomimori, 2000 ). Umifenovir hydrochloride (Arbidol) is a broad-spectrum antiviral drug, which could effectively resist Influenza A Virus and SARS-CoV-2 in vitro ( Wang et al., 2020 ; Li et al., 2022 ).…”

Section: Discussionmentioning

confidence: 99%

Red recombination enables a wide variety of markerless manipulation of porcine epidemic diarrhea virus genome to generate recombinant virus

Pan,

Mou,

Chen

2024

Front. Cell. Infect. Microbiol.

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Porcine epidemic diarrhea virus (PEDV) is a member of the genera Alphacoronavirus that has been associated with acute watery diarrhea and vomiting in swine. Unfortunately, no effective vaccines and antiviral drugs for PEDV are currently available. Reverse genetics systems are crucial tools for these researches. Here, a PEDV full-length cDNA clone was constructed. Furtherly, three PEDV reporter virus plasmids containing red fluorescent protein (RFP), Nano luciferase (Nluc), or green fluorescence protein (GFP) were generated using Red recombination with the GS1783 E. coli strain. These reporter-expressing recombinant (r) PEDVs showed similar growth properties to the rPEDV, and the foreign genes were stable to culture up to P9 in Vero cells. Using the Nluc-expressing rPEDV, the replication of PEDV was easily quantified, and a platform for rapid anti-PEDV drug screening was constructed. Among the three drugs, Bergenin, Umifenovir hydrochloride (Arbidol), and Ganoderma lucidum triterpenoids (GLTs), we found that GLTs inhibited PEDV replication mainly after the stage of virus “Entry”. Overall, this study will broaden insight into the method for manipulating the PEDV genome and provide a powerful tool for screening anti-PEDV agents.

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Section: Discussionmentioning

confidence: 99%

Red recombination enables a wide variety of markerless manipulation of porcine epidemic diarrhea virus genome to generate recombinant virus

Pan,

Mou,

Chen

2024

Front. Cell. Infect. Microbiol.

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“…Subsequently, they were treated with the extract (250 mg/kg) and 11- O- (4′- O- methyl galloyl)-bergenin (5, 10, and 20 mg/kg). The findings indicated that both treatments inhibited the production of pro-inflammatory cytokines, and serum levels of RF and antiCCP were normalized, with an IC 50 of 250 mg/kg for the extract and 20 mg/kg for 11- O- (4′- O- methyl galloyl)-bergenin [ 176 ].…”

Section: Biological and Pharmacological Activities Of Bergeninmentioning

confidence: 99%

Chemistry and Pharmacology of Bergenin or Its Derivatives: A Promising Molecule

et al. 2023

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Bergenin is a glycosidic derivative of trihydroxybenzoic acid that was discovered in 1880 by Garreau and Machelart from the rhizomes of the medicinal plant Bergenia crassifolia (currently: Saxifraga crassifolia—Saxifragaceae), though was later isolated from several other plant sources. Since its first report, it has aroused interest because it has several pharmacological activities, mainly antioxidant and anti-inflammatory. In addition to this, bergenin has shown potential antimalarial, antileishmanial, trypanocidal, antiviral, antibacterial, antifungal, antinociceptive, antiarthritic, antiulcerogenic, antidiabetic/antiobesity, antiarrhythmic, anticancer, hepatoprotective, neuroprotective and cardioprotective activities. Thus, this review aimed to describe the sources of isolation of bergenin and its in vitro and in vivo biological and pharmacological activities. Bergenin is distributed in many plant species (at least 112 species belonging to 34 families). Both its derivatives (natural and semisynthetic) and extracts with phytochemical proof of its highest concentration are well studied, and none of the studies showed cytotoxicity for healthy cells.

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“…A literatura existente sugere que as atividades anti-inflamatórias, antitumoral e de citoproteção da bergenina tem impulsionado novas pesquisas. Notavelmente, todos os oito artigos sobre inflamação relataram associações da bergenina quanto à diminuição de citocinas próinflamatórias em colite, bronquite crônica e artrite (14,15). Nessa perspectiva, os estudos deram luz a uma nova possível classe de medicamentos com variadas aplicações à base de um produto natural.…”

Section: Atividade Farmacológicaunclassified

“…A atividade anti-inflamatória foi descrita para o composto isolado pela primeira vez de Crassula capitella identificado como 11 -O-(4'-O metil galoil)-bergenina, o qual foi capaz de reduzir a progressão e gravidade da artrite reumatóide em ratos, por meio de mecanismo antioxidante, antiinflamatório e estabilizador de membrana (14). Um derivado da bergenina, o metilbergenina, extraído da Ardisia japonica, apresentou promissora atividade anti-inflamatória ao inibir a produção de óxido nítrico em macrófagos murinos RAW 264.7 estimulados por lipolissacarídeos (16).…”

Section: Atividade Anti-inflamatóriaunclassified

Atividades Farmacológicas De Berginina E Derivados: Uma Revisão Sistemática

Veloso

Almeida²,

Lima³

2023

RECIMA21

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A bergenina é um C-glicosídeo do ácido 4-O-metil-gálico, caracteriza-se como um polifenol cristalino e incolor. Há relatos de ter sido isolada de plantas medicinais como Flueggea leucopyrus, Bergenia crassifolia, Mallotus philippensis, Corylopsis spicata, Caesalpinia digyna, Mallotus japonicus e Sacoglottis gabonensis. Na região amazônica especificamente a bergenina é listada como um dos principais compostos bioativos presentes na espécie Endopleura uchi, popularmente conhecida como uchi amarelo. É uma substância que possui múltiplas propriedades farmacológicas como anti-inflamatória, antitumoral, citoprotetora, antiarrítmica, antimicrobiana, antidiabética dentre outras. Por meio de um levantamento bibliográfico nas bases de dados PubMed e Science Direct, entre 2016 e 2022, utilizando os descritores “bergenin”, “pharmacological activity”, “synthesis” e “antioxidant”, após a aplicação dos critérios de inclusão e exclusão, foram avaliados um total de 35 artigos sobre a bergenina e derivados. Os resultados evidenciaram que as propriedades farmacológicas mais recorrentes atribuídas à bergenina, foram aquelas relacionadas as atividades anti-inflamatórias (8 publicações), seguida de antitumoral (5 publicações), citoproteção (5 publicações), ação sobre o metabolismo ósseo (3 publicações), imunomoduladora (3 publicações), antiparasitária (2 publicações) e atividade antioxidante (2 publicações). Dos 35 artigos estudados, seis eram produções relacionadas a derivados da bergenina, os quais estudaram propriedades anti-inflamatória e antitumoral. Esta revisão apresenta uma pesquisa bibliográfica abrangente de diferentes estudos e fornece informações sobre a potencialidade da bergenina e seus derivados para uso e desenvolvimento de novos fármacos.

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Anti-arthritic activity of 11-O-(4′-O-methyl galloyl)-bergenin and Crassula capitella extract in rats

Abstract: Crassula capitella is a new natural and abundant source for 11-O-(4'-O-methyl galloyl)-bergenin for resolving chronic inflammatory diseases as RA through antioxidant, anti-inflammatory and membrane stabilizing mechanism.

Cited by 21 publications

References 42 publications

Red recombination enables a wide variety of markerless manipulation of porcine epidemic diarrhea virus genome to generate recombinant virus

Red recombination enables a wide variety of markerless manipulation of porcine epidemic diarrhea virus genome to generate recombinant virus

Chemistry and Pharmacology of Bergenin or Its Derivatives: A Promising Molecule

Atividades Farmacológicas De Berginina E Derivados: Uma Revisão Sistemática

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