Anti-arthritic and anti-inflammatory activity of Xanthium srtumarium L. ethanolic extract in Freund's complete adjuvant induced arthritis

Patil, Mithun Vishwanath K.; Kandhare, Amit D.; Bhise, Sucheta D.

doi:10.1016/j.biomag.2012.01.002

Cited by 118 publications

(66 citation statements)

References 42 publications

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“…Freund's complete adjuvant-induced arthritis is a well established rat model and has been widely used from many years for evaluation of the anti-inflammatory and anti-arthritic potential of various agents. (14,15) Nagakura et al (10) reported that the induction of arthritis in the Freund's adjuvant model in rats caused joint inflammation, inflammatory cell infiltration, and cartilage and bone destruction. Freund's adjuvant contains Mycobacterium tuberculosis H37Ra or Mycobacterium butyricum, which release endotoxins that trigger the production of nitric oxide (NO).…”

Section: Discussionmentioning

confidence: 99%

Psidium guajava leaves decrease arthritic symptoms in adjuvant-induced arthritic rats

Baroroh

Utami

Soeroso

2016

UnivMed

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Section: Discussionmentioning

confidence: 99%

Psidium guajava leaves decrease arthritic symptoms in adjuvant-induced arthritic rats

Baroroh

Utami

Soeroso

2016

UnivMed

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“…Nitric oxide (NO) is an intracellular messenger and performs various pathological and physiological processes. It serves as an oxidant and traps ROS and protects the cell from lipid peroxidation, DNA damage, and cell death (Patil et al, 2012b. Polymorphonuclear leukocyte (PMNL) accumulation is reflected by the elevated level of myeloperoxidase (MPO) .…”

Section: Discussionmentioning

confidence: 99%

Wound healing potential of naringin ointment formulation via regulating the expression of inflammatory, apoptotic and growth mediators in experimental rats

Kandhare

Alam

Patil

et al. 2015

Pharmaceutical Biology

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Context: Wound healing is a consequence of a complex process involving inflammatory, proliferative, and remodeling phases. Naringin, a flavanone glycoside, is associated with modulation of various oxido-inflammatory and growth factors. Aim: The aim of this study is to evaluate the wound-healing activity of naringin ointment formulation (NOF) on experimental wound models. Materials and methods: A soft paraffin-based cream containing 1, 2, and 4% (w/w) naringin was formulated and evaluated for physicochemical characters. Excision wounds and incisions wounds were used to study the topical effect of NOF for 20 d (once a day) on various biochemical, molecular, and histological parameters. Results: NOF (2 and 4%, w/w) treatment showed a significant decrease (p50.05) in wound area and epithelization period whereas the rate of wound contraction increased significantly (p50.05). The altered levels of oxido-nitrosative stress (SOD, GSH, MDA, MPO, and NO) were significantly (p50.05) restored by NOF. Treatment produced a significant increase (p50.05) in tensile strength, hydroxyproline content, and protein content. TNF-a, IL-1b, IL-6, IL-8, NF-jB, smad-7, and Bax mRNA expression were significantly down-regulated (p50.05) by NOF, whereas polymerase gamma (pol-g), smad-3, VEGF and TGF-b, and collagen-1 mRNA expressions were significantly up-regulated (p50.05) by NOF. Histological alterations in wound skin were also restored by NOF. Conclusion: NOF exerts wound healing potential via down-regulated expression of inflammatory (NF-jB, TNF-a, and ILs), apoptotic (pol-g and Bax), and up-regulated growth factor (VEGF and TGF-b) expression, thus modulating collagen-1 expression to induce angiogenesis leading to wound healing.

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“…It involves the formation and propagation of lipid radicals, the uptake of oxygen and rearrangement of double bonds in unsaturated lipids which eventually results in destruction of membrane lipids [41][42][43][44][45][46] . Biological membranes are often rich in unsaturated fatty acids and bathed in oxygen-rich metal containing fluid 47,48 . Therefore it is not surprising that membrane lipids are susceptible to peroxidative attack 49,50 .…”

Section: Discussionmentioning

confidence: 99%

Antiulcer Potential of Morin in Acetic acid-Induced Gastric Ulcer via Modulation of Endogenous Biomarkers in Laboratory Animals

Bodhankar¹,

Sarkar²,

Sengupta³

et al. 2015

Pharmacologia

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Background: Peptic ulcer disease is a result of an imbalance between aggressive and defensive factors. Morin, a bioflavonoid exhibits many biological activities such as antioxidant and anti-inflammatory properties. Objective: The present study was conducted to unravel the therapeutic potential of morin in acetic acid-induced gastric ulcer. Materials and Methods: Gastric ulcer was induced in male Wistar rats (180-220 g) by applying glacial acetic acid (10 M, 100 μL) to serosa of the stomach. Morin (10, 30 and 100 mg kgG 1 , p.o.) was administered for 15 days after the induction of ulcer. After end of treatment gastric specimens were collected for biochemical and histological evaluation. Results: There was a significant (p<0.01 and p<0.05) reduction in the ulcer area and ulcer index by morin (30 and 100 mg kgG 1 ) treatment. It also significantly (p<0.01 and p<0.05) decreased the level of malondialdehyde (MDA) and increased levels of superoxide dismutase (SOD) as well as reduced glutathione (GSH). Histological aberration induced by acetic acid also reduced by morin administration. Conclusion: The present findings elucidate the antiulcer potential of morin in the acetic acid induced gastric ulcer by virtue of its antioxidant property.

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Anti-arthritic and anti-inflammatory activity of Xanthium srtumarium L. ethanolic extract in Freund's complete adjuvant induced arthritis

Cited by 118 publications

References 42 publications

Psidium guajava leaves decrease arthritic symptoms in adjuvant-induced arthritic rats

Psidium guajava leaves decrease arthritic symptoms in adjuvant-induced arthritic rats

Wound healing potential of naringin ointment formulation via regulating the expression of inflammatory, apoptotic and growth mediators in experimental rats

Antiulcer Potential of Morin in Acetic acid-Induced Gastric Ulcer via Modulation of Endogenous Biomarkers in Laboratory Animals

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