Anti-Arthritic Effect of Chebulanin on Collagen-Induced Arthritis in Mice

Zhao, Yong; Liu, Fang; Liu, Yao; Zhou, Dan; Dai, Qing; Liu, Songqin

doi:10.1371/journal.pone.0139052

Cited by 25 publications

(16 citation statements)

References 39 publications

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“…ROS could activate various pathways that mediate inflammation under psoriatic condition [23]. TC is a polyphenolic compound that was found to possess antioxidant and anti-inflammatory activities [16,17].…”

Section: Discussionmentioning

confidence: 99%

“…Cells were maintained in a humidified atmosphere of 5% CO 2 at 37°C. M5 cocktail (interleukin (IL)-1α, IL-17A, IL-22, Oncostatin M and TNFα, each at 10 ng/ml) was used to induce psoriasis-like inflammation in HaCaT cells [16,21]. Cells were incubated with 10 μg/ml TC for 2 h and then exposed to M5 for 2 days with the presence of TC.…”

Section: Cell Culture and Transfectionmentioning

confidence: 99%

“…Researchers have isolated three polyphenolic compounds from the fruits of terminalia chebula retzius, including chebulagic acid, chebulanin, and chebulinic acid [14,15]. Zhao et al have found that terminalia chebulanin (TC) functions as an anti-inflammatory agent in lipopolysaccharide-stimulated RAW 264.7 cells and in collagen-induced arthritis in a mice model [16]. Moreover, terminalia chebula was shown to attenuate DMBA/croton oil-induced oxidative stress and inflammation in skin of Swiss albino mouse [17].…”

Section: Introductionmentioning

confidence: 99%

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Terminalia Chebulanin Attenuates Psoriatic Skin Lesion via Regulation of Heme Oxygenase-1

Li²,

Dong³

et al. 2016

Cell Physiol Biochem

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Background/Aims: Psoriasis is one of the most common inflammatory skin disorders, affecting 3% of the general population. Terminalia chebulanin (TC) is a polyphenolic compound that possesses antioxidant and anti-inflammatory activities. The current study was designed to investigate the effect of TC on psoriatic lesions. Methods: We examined the protective effect of TC against psoriatic lesions in mice and keratinocyte proliferation in HaCaT cells. Results: We found that TC exhibited potent anti-psoriatic activities, as evidenced by improvement of erythema and scaling scores, decrease of epidermal, ear and skinfold thickening, decrease of tumor necrosis factor α (TNFα), interleukin (IL)-17A, IL-23 and matrix metalloproteinase (MMP)-9 expression, and decrease of TBARS content and increase of GSH content in IMQ-treated mice, and decrease of keratinocyte proliferation, TNFα, IL-17A and IL-23 expression, and ROS level in M5-treated cells. All those effects induced by TC were inhibited by zinc protoporphyrin IX (ZnPP), an inhibitor of heme oxygenase (HO)-1, indicating that HO-1 was responsible the anti-psoriatic effect of TC. Moreover, TC inhibited the upregulation of p65 NF-κB under in vitro psoriatic condition. ZnPP suppressed TC-induced inhibition of p65 NF-κB expression. Overexpression of p65 NF-κB significantly suppressed TC-induced decrease of TNFα, IL-17A and IL-23 expression and keratinocyte proliferation, indicating that HO-1-mediated downregulation of NF-κB was involved in the anti-psoriatic effect of TC. Conclusions: The data demonstrate that TC may serve as a potential therapeutic option for psoriatic patients.

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Section: Discussionmentioning

confidence: 99%

Section: Cell Culture and Transfectionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Terminalia Chebulanin Attenuates Psoriatic Skin Lesion via Regulation of Heme Oxygenase-1

Li²,

Dong³

et al. 2016

Cell Physiol Biochem

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“…Joint inflammation is the dominant clinical manifestation in RA. Chebulanin, kinsenoside, and triptolide effectively suppress the expression of inflammatory mediators in the joint (Hsiao, Hsieh, Wu, Lin, & Lin, ; Lin et al, ; Zhao et al, ). In addition to the effects of the chemical constituents on the whole joint, they also have specific anti‐inflammatory effects on certain compartments of the joint.…”

Section: The Anti‐ra Activities Of Chemical Constituents From Herbal mentioning

confidence: 99%

Herbal compounds for rheumatoid arthritis: Literatures review and cheminformatics prediction

Zhang

2019

Phytotherapy Research

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Rheumatoid arthritis (RA) is a systemic disease characterized by autoimmunity, joint inflammation, and cartilage destruction, which affects 0.5–1% of the population. Many compounds from herbal medicines show the potentials to treat RA. On this basis, the compounds with good pharmacokinetic behaviors and drug‐likeness properties will be further studied and developed. Therefore, the herbal compounds with anti‐RA activities were reviewed in this paper, and the cheminformatics tools were used to predict their drug‐likeness properties and pharmacokinetic parameters. A total of 90 herbal compounds were analyzed, which were reported to be effective on RA models through anti‐inflammation, chondroprotection, immunoregulation, antiangiogenesis, and antioxidation. Most of the herbal compounds have good drug‐likeness properties. Most of the compounds can be an alternative and valuable source for anti‐RA drug discovery.

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“…Gautam et al [42] showed curative effect of T. chebula extract on acetic acid-induced experimental colitis and indicated the presence of active principles with proven antioxidants, anti-inflammatory, immunomodulatory, and free radical scavenging and healing properties in the extract. Recently Zhao et al [72] showed that chebulanin, isolated from T. chebula suppresses the expression of inflammatory mediators and prevents cartilage destruction and bone erosion in mice. Therefore, authors concluded that chebulanin is a strong therapeutic alternative for the treatment of rheumatoid arthritis.…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

Terminalia chebula Retz. – an important medicinal plant

et al. 2017

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Summary Ayurveda, whispered to be the ancient practice of healthcare existed and contributes a holistic approach to health, healing and longevity. Terminalia chebula Retz. is a popular plant and widely spread all over southern Asia. T. chebula is a native plant of India and its dried fruit is extensively used in various types of home remedies. Dried fruit of T. chebula contains high quantities phenolic compounds that consist of ellagic acid, gallic acid and chebulic acid. The fruit extract of T. chebula is known to display different biological properties like anticancer, anti-inflammatory, antioxidant, anti-protozoal, antimicrobial, hepato and renal protective activities, and in the management of metabolic syndrome. The phenolic active compounds might play vital role in the influence of biological activity. Fruit extract of T. chebula is widely employed as an important ingredient in various ayurvedic preparations like ‘Triphala’. This formulation is beneficial as detoxifying agent of the colon, purgative in chronic constipation, aids in digestion and as a body rejuvenator. The fruit has great medicinal significance and conventionally applied for the management of various illness conditions, such as sore throat, high cough, asthma, ulcers, gout, heart burn, vomiting, diarrhea, dysentery, bleeding piles and bladder diseases. It is also utilized as mild laxative, antispasmodic and stomachic. Because of these enormous medicinal properties, T. chebula is commonly termed as ‘King of Medicine’ in Tibet and can be called as a ‘wonder herb’. In the present review, recent advances in medicinal properties of T. chebula are discussed.

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Anti-Arthritic Effect of Chebulanin on Collagen-Induced Arthritis in Mice

Cited by 25 publications

References 39 publications

Terminalia Chebulanin Attenuates Psoriatic Skin Lesion via Regulation of Heme Oxygenase-1

Terminalia Chebulanin Attenuates Psoriatic Skin Lesion via Regulation of Heme Oxygenase-1

Herbal compounds for rheumatoid arthritis: Literatures review and cheminformatics prediction

Terminalia chebula Retz. – an important medicinal plant

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