Anti-asthmatic effect of marine red alga (Laurencia undulata) polyphenolic extracts in a murine model of asthma

Jung, Won‐Kyo; Choi, Inhak; Oh, Sangtaek; Park, Sae-Gwang; Seo, Su‐Kil; Lee, Soo-Woong; Lee, Daesung; Heo, Soo‐Jin; Jeon, You‐Jin; Je, Jae‐Young; Ahn, Chang‐Bum; Kim, Jin-Soo; Oh, Kwang Soo; Kim, Young‐Mog; Moon, Chisook; Choi, Il‐Whan

doi:10.1016/j.fct.2008.11.012

Cited by 75 publications

(46 citation statements)

References 43 publications

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“…Therefore, interfering with the action of IgE represents a potential therapeutic approach for treating asthma and other allergic respiratory diseases. Indeed, the IgE antibody has been viewed as a target for novel immunological drug development in asthma (37). Our data show that serum levels of total and OVA-specific IgE in BALF were significantly reduced by SOEE pretreatment.…”

Section: Discussionsupporting

confidence: 56%

Anti-asthmatic effect of Sanguisorba officinalis L. and potential role of heme oxygenase-1 in an ovalbumin-induced murine asthma model

Lee

Lee²,

Lee³

et al. 2010

Int J Mol Med

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Abstract. Sanguisorba officinalis L. is known to have antiinflammatory properties. However, the potential effects of S. officinalis against asthma have not been reported. In the present study, we investigated the protective effects and underlying mechanisms of S. officinalis in a murine ovalbumin (OVA)-induced asthma model. Mice were sensitized and challenged by OVA inhalation to induce airway inflammation and remodeling. S. officinalis ethanolic extract (SOEE) markedly decreased the number of infiltrated inflammatory cells, together with a reduction in the levels of T-helper type 2 cytokines and immunoglobulin E levels. Histopathological studies showed that inflammatory cell infiltration and mucus hypersecretion were inhibited by SOEE. In addition, OVAinduced increases in reactive oxygen species were attenuated by SOEE. All these effects were correlated with heme oxygenase-1 (HO-1) induction by SOEE. These results indicate that SOEE has therapeutic potential against bronchial asthma associated with allergic diseases that is due, at least in part, to HO-1 upregulation.

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Section: Discussionsupporting

confidence: 56%

Anti-asthmatic effect of Sanguisorba officinalis L. and potential role of heme oxygenase-1 in an ovalbumin-induced murine asthma model

Lee

Lee²,

Lee³

et al. 2010

Int J Mol Med

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“…With regard to TNF-α, this can be secreted by mast cells and could be implicated in Th2-mediated allergic inflammation promoting the homing of Th2 cells to the site of allergic inflammation [32]. Similar effects on IL-10 and TNFα mediated by flavonoids given in allergic conditions have been reported [28,33,34]. In addition, the inhibitory effect of a cocoa diet on TNF-α synthesis has been described [16,35].…”

Section: Discussionmentioning

confidence: 66%

A diet enriched with cocoa prevents IgE synthesis in a rat allergy model

Abril-Gil¹,

Massot-Cladera²,

Pérez-Cano³

et al. 2012

Pharmacological Research

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Previous studies in young rats reported the impact of cocoa intake on healthy immune status and allow suggesting it may have a role in the prevention of some immune-mediated diseases. The aim of this study was to ascertain the effect of a cocoa diet in a model of allergy in young rats. Three-week-old Brown Norway rats were immunized by i.p. injection of ovalbumin (OVA) with alum as adjuvant and Bordetella pertussis toxin. During the next 4 weeks rats received either a cocoa diet (containing 0.2% polyphenols, w/w) or a standard diet. Animals fed a standard diet showed high concentrations of anti-OVA IgG1, IgG2a, IgG2b and high anti-OVA IgE titres, which is the antibody involved in allergic response. In contrast, animals fed a cocoa diet showed significantly lower concentrations of anti-OVA IgG1 and IgG2a antibodies. Interestingly, the cocoa diet prevented anti-OVA IgE synthesis and decreased total serum IgE concentration. Analysis of cytokine production in lymph node cells at the end of the study revealed that, in this compartment, the cocoa diet decreased the tumor necrosis factor (TNF) -α and the interleukin (IL) -10 secretion but not IL-4 production. In conclusion, a cocoa-enriched diet in young rats produces an immunomodulatory effect that prevents anti-allergen IgE synthesis, suggesting a potential role for cocoa flavonoids in the prevention or treatment of allergic diseases. 3

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“…In agreement with our results, Frías et al in 2011 demonstrated the presence of carbohydrates, proteins, triterpenes and steroids in the aqueous extract from D. obtusata. Some of these compounds, such as phenols, terpenes, polysaccharides and steroids, have been reported to possess anti-inflammatory and antinociceptive effects (Silva, Scheuer, 1980;Chong, Parish, 1985;Awad, 2000;Lucas et al, 2003;Rodríguez et al, 2004;Jung et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

“…A group of inhibitors of phospholipase A 2 were isolated from different microalgae (Mayer et al, 1993). Recently, other metabolites with antiinflammatory activity have been obtained from seaweeds, including a glycosterol (Awad, 2000), a phlorotannin (Sugiura et al, 2006), polyphenols (Jung et al, 2009;El Gamal, 2010) and polysaccharides (Ananthi et al, 2010). Moreover, various seaweeds have antinociceptive properties (Anca et al, 1993;Guzmán et al, 2001;Viana et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory and antinociceptive activities of methanolic extract from red seaweed Dichotomaria obtusata

Delgado

Vázquez

Sánchez³

et al. 2013

Braz. J. Pharm. Sci.

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The aim of the present work was to investigate the anti-inflammatory and antinociceptive effects of methanolic extract from D. obtusata using classic models in mice (croton oil-induced ear edema and acetic acid-induced writhing) and a phospholipase A 2 activity test. Qualitative analysis of the chemical composition of seaweed was also determined by extraction with solvents of increasing polarity and precipitation and color tests. Results of qualitative chemical study showed the presence of lactonic and phenolic compounds, reduced carbohydrates, other sugars, flavonoids, fatty compounds, triterpenes and steroids. The extract inhibited mouse ear edema in a dose-dependent manner with an efficacy higher than 90% and a mean effective dose of 4.87μg/ear, while intraperitoneal administration presented a moderate activity. The extract did not inhibit phospholipase A 2 activity. In the writhing test, the intraperitoneal administration of the extract showed a strong antinociceptive activity (80.2%), while the oral route showed a lower efficacy. In conclusion, this study demonstrated the anti-inflammatory and antinociceptive effects of methanol extract of D. obtusata in experimental models, suggesting its therapeutic potential in the treatment of peripheral painful and/or inflammatory pathologies. O objetivo do presente trabalho foi investigar os efeitos antiinflamatórios e antinociceptivos de um extrato metanólico de D. obtusata, utilizando modelos clássicos em ratos (teste do edema de orelha induzido por óleo de cróton e teste de contorções induzidas por ácido acético) e um teste de atividade de fosfolipase A 2 . A análise qualitativa da composição química das algas foi também determinada através de extração com solventes de polaridade crescente e testes de precipitação e cor. Os resultados do estudo de química qualitativa mostraram a presença de compostos lactônicos e fenólicos, hidratos de carbono reduzidos e outros açúcares, flavonoides, compostos graxos, triterpenos e esteroides. O extrato inibiu o edema de orelha dos ratos de um modo dependente da dose com eficácia superior a 90% e dose média efetiva de 4.87μg/orelha, enquanto a administração intraperitoneal apresentou atividade moderada. O extrato não inibiu a atividade da fosfolipase A 2 . No teste de contorção, a administração intraperitoneal do extrato mostrou forte atividade antinociceptiva (80,2%), enquanto a administração oral mostrou menor eficácia. Em conclusão, este estudo demonstrou os efeitos antiinflamatórios e antinociceptivos do extrato metanólico de D. obtusata em modelos experimentais, sugerindo seu potencial terapêutico no tratamento de patologias dolorosas periféricas e/ou inflamatórias. UnitermsUnitermos: Dichotomaria obtusata/farmacognosia. Dichotomaria obtusata/atividade antiinflamatória. Dichotomaria obtusata/atividade antinociceptiva. Teste do edema de orelha. Teste de contorções.

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Anti-asthmatic effect of marine red alga (Laurencia undulata) polyphenolic extracts in a murine model of asthma

Cited by 75 publications

References 43 publications

Anti-asthmatic effect of Sanguisorba officinalis L. and potential role of heme oxygenase-1 in an ovalbumin-induced murine asthma model

Anti-asthmatic effect of Sanguisorba officinalis L. and potential role of heme oxygenase-1 in an ovalbumin-induced murine asthma model

A diet enriched with cocoa prevents IgE synthesis in a rat allergy model

Anti-inflammatory and antinociceptive activities of methanolic extract from red seaweed Dichotomaria obtusata

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