Anti-asthmatic effects of tannic acid from Chinese natural gall nuts in a mouse model of allergic asthma

Rajasekar, N.; Sivanantham, Ayyanar; Kar, Amrita Ghosh; Mukhopadhyay, Sabyasachi; Mahapatra, Santanu Kar; Paramasivam, Sudhakar Gandhi; Rajasekaran, Subbiah

doi:10.1016/j.intimp.2021.107847

Cited by 10 publications

(3 citation statements)

References 56 publications

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“…Moreover, the compound attenuated the expression of mucins (Muc5ac and Muc5b), mucus production in airway goblet cells, mast cell infiltration, and airway remodeling. The mechanism was attributed to the impairment of NF-κB and adhesion molecules at the lung epithelial level [ 91 ].…”

Section: Resultsmentioning

confidence: 99%

Hydrolyzable Tannins in the Management of Th1, Th2 and Th17 Inflammatory-Related Diseases

et al. 2022

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Plants rich in hydrolyzable tannins were traditionally used all over the world for a variety of chronic inflammatory disorders, including arthritis, colitis, and dermatitis. However, the knowledge of their immunological targets is still limited though fundamental for their rational use in phytotherapy. The recent advances regarding the pathogenesis of inflammatory-based diseases represent an opportunity to elucidate the pharmacological mechanism of plant-derived metabolites with immunomodulatory activity. This review collects recent articles regarding the role of hydrolyzable tannins and their gut metabolites in Th1, Th2, and Th17 inflammatory responses. In line with the traditional use, rheumatoid arthritis (RA), inflammatory bowel diseases (IBDs), psoriasis, atopic dermatitis (AD), and asthma were the most investigated diseases. A substantial body of in vivo studies suggests that, beside innate response, hydrolyzable tannins may reduce the levels of Th-derived cytokines, including IFN-γ, IL-17, and IL-4, following oral administration. The mode of action is multitarget and may involve the impairment of inflammatory transcription factors (NF-κB, NFAT, STAT), enzymes (MAPKs, COX-2, iNOS), and ion channels. However, their potential impact on pathways with renewed interest for inflammation, such as JAK/STAT, or the modulation of the gut microbiota demands dedicate studies.

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Section: Resultsmentioning

confidence: 99%

Hydrolyzable Tannins in the Management of Th1, Th2 and Th17 Inflammatory-Related Diseases

et al. 2022

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“…A marker of successful AIT is the correction of the imbalance between Th1 and Th2 responses [ 30 ]. In the first experiment, rArt v4.01 was dominated by inhibition of the levels of Th2 cell-associated factors (IL-4 and IL-2), in which IL-2 could induce conversion of Th0 to Th2 cells [ 31 ]. It indicated that rArt v4.01 could inhibit Th2 response more than wormwood, which is similar to Hesse et al’s finding [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

Recombinant Art v4.01 protein produces immunological tolerance by subcutaneous immunotherapy in a wormwood pollen-driven allergic asthma female mouse model

Wang,

Chi,

et al. 2024

PLoS ONE

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Art v4.01 is a well-known profilin protein belonging to the pan-allergens group and is commonly involved in triggering allergic asthma, polyallergy, and cross-sensitization. It is also referred to as Wormwood due to its origin. Crude wormwood extracts are applied for allergen-specific immunotherapy (AIT). Whether the recombinant Art v4.01 (rArt v4.01) can produce in vivo immunological tolerance by subcutaneous immunotherapy (SCIT) remains elusive. In this study, to investigate the in vivo immunological response of rArt v4.01, Th2, Th1, Treg, Th17 type-related cytokines and phenotypes of immune cells were tested, facilitating the exploration of the underlying mechanisms. The expression and purification of Art v4.01 were carried out using recombinant techniques. Allergic asthma female BALB/c mice were induced by subcutaneous sensitization of wormwood pollen extract and intranasal challenges. SCIT without adjuvant was performed using the rArt v4.01 and wormwood pollen extract for 2 weeks. Following exposure to challenges, the levels of immunoglobulin E (IgE), cytokines, and inflammatory cells were assessed through enzyme-linked immunosorbent assay (ELISA) and histological examination of sera, bronchoalveolar lavage fluid (BALF), and lung tissue. These parameters were subsequently compared between treatment groups receiving rArt v4.01 and wormwood pollen extract. The rArt v4.01 protein was expressed, which had a high purity (>90%) and an allergenic potency. Compared with the pollen extract, rArt v4.01 was superior in terms of reducing the number of white blood cells (WBCs), total nucleated cells (TNCs), and monocytes (MNs) in BALF and the degree of lung inflammation (1.77±0.99 vs. 2.31±0.80, P > 0.05). Compared with the model group, only rArt v4.01 reduced serum IgE level (1.19±0.25 vs. 1.61±0.17 μg/ml, P = 0.062), as well as the levels of Th2 type-related cytokines (interleukin-4 (IL-4) (107.18±16.17 vs. 132.47±20.85 pg/ml, P < 0.05) and IL-2 (19.52±1.19 vs. 24.02±2.14 pg/ml, P < 0.05)). The study suggested that rArt v4.01 was superior to pollen extract in reducing the number of inflammatory cells in BALF, pneumonitis, levels of pro-inflammatory cytokines, and serum IgE level. These findings confirmed that Art v4.01 could be a potential candidate protein for allergen-specific immunotherapy.

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“…Therefore, a direct effect on immunocompetent cells may also be involved [ 23 ]. TA also decreased the production of inflammatory cytokines, IgE, and histamine in an OVA-induced rhinitis murine model (BALB/c) [ 24 , 25 ].…”

Section: Discussionmentioning

confidence: 99%

Co-Application with Tannic Acid Prevents Transdermal Sensitization to Ovalbumin in Mice

Izumi

Tanahashi

Kinugasa

et al. 2022

IJMS

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Transdermal sensitization to allergens is of great concern as a sensitization route for food allergies. This skin-mediated invasion and sensitization to allergens is involved in skin barrier breakdown and inflammation, followed by the production of several kinds of cytokines. Cytokines such as thymic stromal lymphopoietin and thymus and activation-regulated chemokine are also involved. In this study, we investigated the suppressive effect of tannic acid (TA) on transdermal sensitization using ovalbumin (OVA), a major egg-white allergen. We also analyzed the mechanisms associated with the inhibitory effects of TA. The results showed that the co-application with TA prevents transdermal sensitization to OVA. As possible mechanisms, its anti-inflammatory and astringent effect on the skin and binding ability with the protein were considered. These results indicate that TA could be applied to cosmetics and lotions, which could suppress the transdermal sensitization to allergens.

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Anti-asthmatic effects of tannic acid from Chinese natural gall nuts in a mouse model of allergic asthma

Cited by 10 publications

References 56 publications

Hydrolyzable Tannins in the Management of Th1, Th2 and Th17 Inflammatory-Related Diseases

Hydrolyzable Tannins in the Management of Th1, Th2 and Th17 Inflammatory-Related Diseases

Recombinant Art v4.01 protein produces immunological tolerance by subcutaneous immunotherapy in a wormwood pollen-driven allergic asthma female mouse model

Co-Application with Tannic Acid Prevents Transdermal Sensitization to Ovalbumin in Mice

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