Anti‐asthmatic properties of Bio‐Rice in OVA‐induced asthmatic mice

Abstract

From the long time, polysaccharides and saponin have been used in the traditional medicine to treat several diseased conditions including inflammatory disease. In this study, we investigated the anti‐asthmatic effect of Bio‐Rice, a rich source of polysaccharides and saponin in OVA‐induced asthmatic mice model. Forty OVA‐induced asthmatic BALB/c mice were equally divided into four groups, including control, and different concentrations of Bio‐Rice treated groups (1X, 2X and 4X). Respective mice received Bio‐Rice for 8‐week. The anti‐asthmatic effect of Bio‐Rice was determined by observing eosinophil recruitment, airway hyper‐responsiveness, Th2 cytokine and IgE levels. The Bio‐Rice treatment effectively reduced the percentage of eosinophils in BALF when compared to the level in OVA‐induced mice. Bio‐Rice also suppressed AHR‐induced by aerosolized methacholine. Furthermore, Bio‐Rice treatment suppressed the serum IgE level and decreased Th2 cytokines in the supernatant of cultured splenocytes. These results suggest that Bio‐Rice may have therapeutic potential against asthma.