This study was purposed to examine the immunomodulatory properties of Bio‐Rice (fermented rice) in OVA‐induced mice model. Total forty BALB/c mice were categorized into four groups, ten in each, and considered as control, and different doses of Bio‐Rice treated groups (1X, 2X and 4X). After 8‐week treatment, the concentrations of interferon‐£^ (IFN‐£^) was increased with 1X, 2X and 4X doses, interleukin‐2 (IL‐2) was increased with 2X and 4X, and IL‐10 was elevated only with 4X dose of Bio‐Rice in the cultured splenocytes of ConA stimulate type. Nevertheless, all the inflammatory cytokines (IL‐2, IL‐10, IL‐5 and IFN‐£^) were elevated withal 4X dose in OVA‐induced mice, IL‐2 and IL‐10 increased with 2X, and no change with 1X. Estimated phagocytosis capacity was increased with 4X dose, and elevated natural killer cell (NK‐cell) activity was found with both 2X and 4X doses. Splenocytes subtype population, such as total T cells (CD4+ and CD8+), N K1.1 and F4/80 cells have been found to significantly higher in 2X and 4X doses of Bio‐Rice. Evidences from this study clearly demonstrating that 8‐week treatment of Bio‐Rice can modulate the immune system in OVA‐induced mice model. Our findings conclude that a fermented food product, such as Bio‐Rice is beneficial to boost the immune system.

From the long time, polysaccharides and saponin have been used in the traditional medicine to treat several diseased conditions including inflammatory disease. In this study, we investigated the anti‐asthmatic effect of Bio‐Rice, a rich source of polysaccharides and saponin in OVA‐induced asthmatic mice model. Forty OVA‐induced asthmatic BALB/c mice were equally divided into four groups, including control, and different concentrations of Bio‐Rice treated groups (1X, 2X and 4X). Respective mice received Bio‐Rice for 8‐week. The anti‐asthmatic effect of Bio‐Rice was determined by observing eosinophil recruitment, airway hyper‐responsiveness, Th2 cytokine and IgE levels. The Bio‐Rice treatment effectively reduced the percentage of eosinophils in BALF when compared to the level in OVA‐induced mice. Bio‐Rice also suppressed AHR‐induced by aerosolized methacholine. Furthermore, Bio‐Rice treatment suppressed the serum IgE level and decreased Th2 cytokines in the supernatant of cultured splenocytes. These results suggest that Bio‐Rice may have therapeutic potential against asthma.