Anti-Atherogenic Effect of Citrus Flavonoids, Naringin and Naringenin, Associated with Hepatic ACAT and Aortic VCAM-1 and MCP-1 in High Cholesterol-Fed Rabbits

Lee, Chul‐Ho; Jeong, Tae Sook; Choi, Yang Kyu; Hyun, Byung Hwa; Oh, Goo Taeg; Kim, Eun Hee; Kim, Ju Ryoung; Han, Jang Il; Bok, Song Hae

doi:10.1006/bbrc.2001.5001

Cited by 222 publications

(132 citation statements)

References 32 publications

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“…Naringin is also a strong antioxidant that has protective effects against metal chelation and lipid peroxidation, acting as a free radical scavenger. In addition, due to their blood cholesterol-lowering effect, flavonoids can improve the health status of laboratory animals and prolong the shelf life of poultry products (Ali et al, 2014;Jeon et al, 2002;Lee et al, 2001). This experiment was conducted to compare the antioxidant and cholesterol-reducing effects of hesperidin, quercetin, and naringin in laying chickens.…”

Section: The Effects Of Dietary Flavonoid Supplementation On the Antimentioning

confidence: 99%

The Effects of Dietary Flavonoid Supplementation on the Antioxidant Status of Laying Hens

İskender

Yenice

Dokumacıoğlu

et al. 2016

Rev. Bras. Cienc. Avic.

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Ninety-six 28-week-old Lohmann White laying hens were utilized to test the antioxidant effects of flavonoids (hesperidin, naringin, and quercetin at 0.5 g/kg diet) during an 8-wk experimental period. At the end of the experiment blood samples were collected to determine total protein, cholesterol, and malondialdehyde (MDA) serum levels as well as activities of glutathione reductase (GR), glutathione peroxidase (GSH-Px), glutathione-S-transferase (GST), and superoxide dismutase (SOD) and level of glutathione (GSH) in erythrocyte lysates. Data were analyzed using one-way ANOVA. Naringin supplementation did not alter serum cholesterol concentration, whereas hesperidin and quercetin supplementations decreased serum cholesterol concentration. Naringin and quercetin supplementations did not affect serum protein concentration. All flavonoids decreased MDA concentration as well as increased GSH-Px, GR, GST, and SOD activities and GSH level, being quercetion superior to hesperidin and naringin. In conclusion, flavonoids, especially quercetin, exert antioxidant activity, which may help improve wellbeing when laying hens are exposed to stressors.

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Section: The Effects Of Dietary Flavonoid Supplementation On the Antimentioning

confidence: 99%

The Effects of Dietary Flavonoid Supplementation on the Antioxidant Status of Laying Hens

İskender

Yenice

Dokumacıoğlu

et al. 2016

Rev. Bras. Cienc. Avic.

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“…NRG has been reported to posses several effects on biological system such as antioxidant (Rice-Evans et al, 1996;Cao et al, 1997), anti-inflammatory (Manthey 2000), anticancer (Goldwasser, 2010), antifibrogenic (Lee et al, 2004) and antiatherogenic (Lee et al, 2001). The beneficial effects on human health are mainly due to their antioxidant activity and ability to chelate metals, to scavenge oxygen free-radical, to inhibit enzymes and to prevent oxidation of low-density lipoproteins (LDL) (Madsen et al, 2000;Yu et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Self-nanoemulsifying drug delivery system (SNEDDS) of the poorly water-soluble grapefruit flavonoid Naringenin: design, characterization,in vitroandin vivoevaluation

et al. 2014

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(2015) Self-nanoemulsifying drug delivery system (SNEDDS) of the poorly water-soluble grapefruit flavonoid Naringenin: design, characterization, invitro and invivo evaluation, Drug Delivery, 22:4, 552-561, DOI: 10.3109/10717544.2013 Abstract Naringenin (NRG), predominant flavanone in grapefruits, possesses anti-inflammatory, anti-carcinogenic, hepato-protective and anti-lipid peroxidation effects. Slow dissolution after oral ingestion due to its poor solubility in water, as well as low bioavailability following oral administration, restricts its therapeutic application. The study is an attempt to improve the solubility and bioavailability of NRG by employing self-nanoemulsifying drug delivery technique. Preliminary screening was carried out to select oil, surfactant and co-surfactant, based on solubilization and emulsification efficiency of the components. Pseudo ternary phase diagrams were constructed to identify the area of nanoemulsification. The developed selfnanoemulsifying drug delivery systems (SNEDDS) were evaluated in term of goluble size, globule size distribution, zeta potential, and surface morphology of nanoemulsions so obtained. The TEM analysis proves that nanoemulsion shows a droplet size less than 50 nm. Freeze thaw cycling and centrifugation studies were carried out to confirm the stability of the developed SNEDDS. In vitro drug release from SNEDDS was significantly higher (p50.005) than pure drug. Furthermore, area under the drug concentration time-curve (AUC 0-24 ) of NRG from SNEDDS formulation revealed a significant increase (p50.005) in NRG absorption compared to NRG alone. The increase in drug release and bioavailability as compared to drug suspension from SNEDDS formulation may be attributed to the nanosized droplets and enhanced solubility of NRG in the SNEDDS.

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“…The recoveries of four compounds ranged from 97.43% to 102.84%, and all of the RSDs were less than 2.0%, which implied the extraction procedure was efficient (Tables VII and VIII). For stability test, a sample solution was analyzed after being stored at room temperature for 1,4,8,12, and 24 h and was found to be relatively stable within 24 h (RSD < 2.0%).…”

Section: Methods Validationmentioning

confidence: 99%

“…That was why naringin, rhoifolin, meranzin hydrate, and isoimperatorin ( Fig. 1) were chosen as determination targets [3,[11][12][13][14][15][16]. Consequently, to establish a method for the quality control of CGE is quite a necessity so as to distinguish different plant origins and make better use of genuine medicinal materials.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous determination of four major constituents in Citri Grandis Exocarpium by HPLC-DAD

Liu

et al. 2016

Acta Chromatographica

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Summary. Citri Grandis Exocarpium (CGE) is a traditional Chinese medicine with a variety of biological activities. For efficient quality control of CGE, a simple, rapid, and accurate high-performance liquid chromatographic (HPLC) method was developed for simultaneous determination of four main compounds (naringin, rhoifolin, meranzin hydrate, and isoimperatorin) in this herb. These four compounds were separated on a C 18 column by gradient elution with methanol and water. The flow rate was 1.0 mL·min −1 , and the detection wavelength was 324 nm. The recoveries of the method ranged from 96.32% to 103.71%, and good linear relationships (r 2 > 0.9998) over relative wide concentration ranges were obtained. Then this validated method was successfully applied to the analysis of nine batches of CGE samples.

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Anti-Atherogenic Effect of Citrus Flavonoids, Naringin and Naringenin, Associated with Hepatic ACAT and Aortic VCAM-1 and MCP-1 in High Cholesterol-Fed Rabbits

Cited by 222 publications

References 32 publications

The Effects of Dietary Flavonoid Supplementation on the Antioxidant Status of Laying Hens

The Effects of Dietary Flavonoid Supplementation on the Antioxidant Status of Laying Hens

Self-nanoemulsifying drug delivery system (SNEDDS) of the poorly water-soluble grapefruit flavonoid Naringenin: design, characterization,in vitroandin vivoevaluation

Simultaneous determination of four major constituents in Citri Grandis Exocarpium by HPLC-DAD

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