Anti-atherosclerosis and hyperlipidemia effects of herbal mixture, Artemisia iwayomogi Kitamura and Curcuma longa Linne, in apolipoprotein E-deficient mice

Synergistic effects of Artemisia iwayomogi and Curcuma longa radix on high-fat diet-induced hyperlipidemia in a mouse model

“…5). These results partially accord with those of previous studies (Li et al, 2010;Shin et al, 2014).…”

“…A. iwayomogi and C. longa are frequently used to treat 'dampness and phlegm' and 'blood stasis', respectively, and both of these conditions are closely related to hyperlipidemia in TKM and TCM (Xie et al, 2012). Our previous study described the anti-atherosclerotic effect of ACE in apoE knockout mice (Shin et al, 2014), and the present study was the first to evaluate the anti-hyperlipidemic properties of both ACE and its constituents, A. iwayomogi and C. longa, in isolation. Per our hypothesis, a 10-week high-fat diet induced hyperlipidemia by significantly elevating serum levels of TC, LDL, and triglycerides; these altered lipid profiles were significantly attenuated by AI, CL, and ACE treatments.…”

“…Another herb, Curcuma longa radix, the therapeutic and anti-hyperlipidemic properties of which are well-documented, has been used to cure pathological 'blood stasis' (Jang et al, 2008;Manjunatha and Srinivasan, 2007;Yiu et al, 2011). TKM practitioners typically use two or more herbs in combination to enhance therapeutic efficacy; in our previous study, the combination of A. iwayomogi and C. longa (ACE) exhibited anti-atherosclerotic activity in an apoE knockout mouse model (Shin et al, 2014). However, no single study has assessed the anti-hyperlipidemic effects of ACE compared with A. iwayomogi and C. longa in isolation.…”

Potential additive effects of garcinia cambogia on atorvastatin treated hyperlipidemic patients: randomized crossover clinical study

“…20 Hence; garlic and lasuna definitely might be an encouraging treatment with statin for hyperlipidemia, also these herbal medications may decrease the dose of atorvastatin and so minimizing the adverse effects and improving the hypolipidemic effect. 21 Therefore; the present study showed significant hypolipidemic effect of garcinia cambogia alone or in combination with atorvastatin through 8 weeks period of treatment. In this study garcinia, cambogia produced significant reductions in serum lipid and improve other lipid parameters like VLDL, and LDL p < 0.05.…”

Potential role of medicinal plants for anti-atherosclerosis activity

“…Turmeric plant can be used as a potentiated plant to treat the hyperlipidemia and atherosclerosis due to the presence of bisdemethoxycurcumin in the rhizome of this plant (Shin et al, 2014). The ethanolic extract was given to the atherogenic rabbit and positive results were shown (Quiles et al, 1998).…”