2017

DOI: 10.7860/jcdr/2017/23910.9864

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Anti-Atherosclerotic Potential of Aqueous Extract of Cinnamomum Zeylanicum Bark against Glucocorticoid Induced Atherosclerosis in Wistar Rats

Im Nagendra Nayak¹,

Rajasekhar Chinta

²

,

³

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Introduction2

Antimicrobial1

Effects Of Cinnamon Mangosteen and Curcumin On Lipid Profi1

Spices With Potential Atheroprotective Effects1

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Cited by 21 publications

(20 citation statements)

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“…Cinnamon is native to Sri Lanka and southern India. It has many uses in food, medicine, pharmaceutical, and cosmetics industries (Han & Parker, 2017;Madhavadas & Subramanian, 2017;Mesripour, Moghimi, & Rafieian-Kopaie, 2016;Nayak, Chinta, & Jetti, 2017;Tulini et al, 2017;Wong et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Protective effects of cinnamon bark extract against ischemia–reperfusion injury and arrhythmias in rat

¹

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²

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³

et al. 2018

Phytotherapy Research

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Cinnamomum zeylanicum (cinnamon) is a plant with potent antioxidant activity and has been used in traditional medicine for improvement of heart function. The effects of cinnamon bark ethanolic extract were investigated against ischemia-induced arrhythmias and heart injury in an in vivo rat model of regional heart ischemia. The extract was also standardized, and its antioxidant activity was evaluated. Adult male Sprague-Dawley rats were subjected to 30 min of ischemia by occlusion of the left anterior descending coronary artery followed by 5 days of reperfusion. Thirty-two animals were randomized to receive daily oral administration of vehicle or C. zeylanicum bark extract (intragastric, 50, 100, or 200 mg/kg) 14 days before ischemia. C. zeylanicum was standardized through HPLC analysis. Administration of cinnamon bark extract significantly improved ischemia/reperfusion-induced myocardial injury as evidenced by reduction of the infarct size. Also, during the ischemic period, ventricular tachycardia and ventricular ectopic beats episodes decreased as compared with that of the control group. The extract stabilized the ST segment changes and QTc shortening, decreased R-wave amplitude, and increased heart rate during ischemia. The extract also caused significant elevations in serum superoxide dismutase and glutation proxidase activities as well as a significant decrease in serum cardiac troponin I, lactate dehydrogenase, and malondialdehyde levels, 5 days after reperfusion. In HPLC analysis, the amounts of Cinamic acid, Methyl eugenol, and Cinnamaldehyde were 8.99 ± 0.5, 13.02 ± 1.8, and 14.63 ± 1.1 mg/g, respectively. The results show that the ethanolic extract of cinnamon bark is able to protect the heart against ischemia-reperfusion injury probably due to its antioxidant properties. Hence, it might be beneficial in these patients and this remedy might be used for preparation of new drugs.

“…Cinnamon is native to Sri Lanka and southern India. It has many uses in food, medicine, pharmaceutical, and cosmetics industries (Han & Parker, 2017;Madhavadas & Subramanian, 2017;Mesripour, Moghimi, & Rafieian-Kopaie, 2016;Nayak, Chinta, & Jetti, 2017;Tulini et al, 2017;Wong et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Protective effects of cinnamon bark extract against ischemia–reperfusion injury and arrhythmias in rat

¹

,

²

,

³

et al. 2018

Phytotherapy Research

View full text Add to dashboard Cite

Cinnamomum zeylanicum (cinnamon) is a plant with potent antioxidant activity and has been used in traditional medicine for improvement of heart function. The effects of cinnamon bark ethanolic extract were investigated against ischemia-induced arrhythmias and heart injury in an in vivo rat model of regional heart ischemia. The extract was also standardized, and its antioxidant activity was evaluated. Adult male Sprague-Dawley rats were subjected to 30 min of ischemia by occlusion of the left anterior descending coronary artery followed by 5 days of reperfusion. Thirty-two animals were randomized to receive daily oral administration of vehicle or C. zeylanicum bark extract (intragastric, 50, 100, or 200 mg/kg) 14 days before ischemia. C. zeylanicum was standardized through HPLC analysis. Administration of cinnamon bark extract significantly improved ischemia/reperfusion-induced myocardial injury as evidenced by reduction of the infarct size. Also, during the ischemic period, ventricular tachycardia and ventricular ectopic beats episodes decreased as compared with that of the control group. The extract stabilized the ST segment changes and QTc shortening, decreased R-wave amplitude, and increased heart rate during ischemia. The extract also caused significant elevations in serum superoxide dismutase and glutation proxidase activities as well as a significant decrease in serum cardiac troponin I, lactate dehydrogenase, and malondialdehyde levels, 5 days after reperfusion. In HPLC analysis, the amounts of Cinamic acid, Methyl eugenol, and Cinnamaldehyde were 8.99 ± 0.5, 13.02 ± 1.8, and 14.63 ± 1.1 mg/g, respectively. The results show that the ethanolic extract of cinnamon bark is able to protect the heart against ischemia-reperfusion injury probably due to its antioxidant properties. Hence, it might be beneficial in these patients and this remedy might be used for preparation of new drugs.

“…Cardiovascular Diseases: Cinnamon was found to inhibit the atherosclerosis process by the prevention of apoA-1 glycation and inhibition of cholesteryl ester transfer protein (CETP) in hypercholesterolemic zebrafish. Cinnamon extract treatment significantly reduced the rate of dyslipidemia and aided in the maintenance of the atherogenic index (total cholesterol-HDL-C/HDL-C) compared to dexamethasone control in atherosclerotic rats [23].…”

Section: Antimicrobialmentioning

confidence: 89%

Medicinal and Nutritional Perspective of Cinnamon: A Mini-review

Goel¹,

²

2020

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The present review establishes the medicinal and nutritional perspectives of Cinnamon. In today’s era, there are so many processed foods available in the market that saves time but processed foods have many adverse effects on health. Cinnamon has significant benefits for human health, particularly as an anti-inflammatory, antitumor, anticancer, antidiabetic and anti-hypertriglyceridemia agent, mainly due to its phytochemical constituents such as phenolic and volatile compounds. So, people are more aware of the usage of the natural herbal product in the diet. Cinnamon (Cinnamomum verum) is the most consumed spice in the world. Cinnamaldehyde is the bioactive component present in the cinnamon. The nutrient content found in cinnamon is in a good amount. Macro and micronutrients such as energy, carbohydrate, vitamin A and C, calcium, iron, magnesium are present. Cinnamon is also known for its health benefits such as antioxidant, anticancer, antibacterial, immunomodulatory and metabolic syndrome. Thus, cinnamon is very beneficial to combat diseases. It is concluded that cinnamon is very useful and beneficial for the maintenance of health and it is helpful in the prevention of diseases.

“…In a hypercholesterolemic zebrafish model, cinnamon was discovered to slow down the atherosclerosis process by preventing glycation of apoA-1 and inhibiting activity of the cholesteryl ester transfer protein (87). Further, in the atherosclerotic animal model induced by dexamethasone, treatment with cinnamon extract improved glucocorticoidinduced dyslipidemia compared to the dexamethasone control group (88). Also, the aqueous cinnamon reduced the expressions of scavenger receptor class A and T cell receptor CD36, as well as uptake of acetyl-low density lipoprotein via regulation of ERK1/2 activity in macrophages (89).…”

Section: Effects Of Cinnamon Mangosteen and Curcumin On Lipid Profimentioning

confidence: 99%

Selected Indonesian Medicinal Plants for the Management of Metabolic Syndrome: Molecular Basis and Recent Studies

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²

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³

2020

Front. Cardiovasc. Med.

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Increased prevalence of metabolic syndrome (MetS) in the world influences quality of health in all respective countries, including Indonesia. Data from Indonesian Family Life Survey reported in 2019 showed that the prevalence of MetS in Indonesia currently is 21.66%, estimated with the provincial incidence ranging up to 50%; additionally, the most common components of MetS discovered in Indonesia were poor high-density lipoprotein (HDL) cholesterol and hypertension. Management treatment of MetS involves a combination of lifestyle changes and pharmacological interventions to decrease cerebrovascular disease. Various natural substances have been shown to govern any cardiovascular or metabolic disorders through different mechanisms, such as triggering anti-inflammation, lipid profile correction, sensitization of insulin reception, or blood glucose control. In Indonesia, the utilization of natural compounds is part of the nation's culture. The community widely uses them; even though in general, their effectiveness and safety have not been thoroughly assessed by rigorous clinical trials. Scientific evidence suggested that cinnamon, mangosteen, and curcumin, as well as their derived components possess a broad spectrum of pharmacological activity. In this review, an enormous potential of cinnamon, mangosteen, and curcumin, which originated and are commonly used in Indonesia, could be treated against MetS, such as diabetes, hyperlipidemia, hypertension, and obesity. The findings suggested that cinnamon, mangosteen, curcumin and their derivatives may reflect areas of promise in the management of MetS.

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