Anti-cancer activity of Biochanin A against multiple myeloma by targeting the CD38 and cancer stem-like cells

Jaina, Vinod Kumar; Edara, Abhishek; SVS, Sasi Priya; Jadav, Surender Singh; Chilaka, Sabarinadh; Sistla, Ramakrishna; Andugulapati, Sai Balaji

doi:10.1016/j.procbio.2022.10.029

Cited by 14 publications

(11 citation statements)

References 51 publications

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“…Mechanistic studies have shown that Biochanin-A’s anti-cancer effects are achieved by modulating the NF-κB and MAPK signalling pathways. This study suggests that Biochanin-A may offer a new, more effective, and less toxic type of treatment for multiple myeloma ( Jaina et al , 2022 ).…”

Section: Biochanin-a and Its Pharmacological Benefitsmentioning

confidence: 86%

Mechanisms Behind the Pharmacological Application of Biochanin-A: A review

Anuranjana,

Beegum,

K.P

et al. 2023

F1000Res

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This review was aimed at summarizing the cellular and molecular mechanisms behind the various pharmacological actions of biochanin-A. Many studies have been reported claiming its application in cancers, metabolic disorders, airway hyperresponsiveness, cardiac disorders, neurological disorders, etc. With regard to hormone-dependent cancers like breast, prostate, and other malignancies like pancreatic, colon, lung, osteosarcoma, glioma that has limited treatment options, biochanin-A revealed agreeable results in arresting cancer development. Biochanin-A has also shown therapeutic benefits when administered for neurological disorders, diabetes, hyperlipidaemia, and other chronic diseases/disorders. Isoflavones are considered phenomenal due to their high efficiency in modifying the physiological functions of the human body. Biochanin-A is one among the prominent isoflavones found in soy (glycine max), red clover (Trifolium pratense), and alfalfa sprouts, etc., with proven potency in modulating vital cellular mechanisms in various diseases. It has been popular for ages among menopausal women in controlling symptoms. In view of the multi-targeted functions of biochanin-A, it is essential to summarize it's mechanism of action in various disorders. The safety and efficacy of biochanin-A needs to be established in clinical trials involving human subjects. Biochanin-A might be able to modify various systems of the human body like the cardiovascular system, CNS, respiratory system, etc. It has shown a remarkable effect on hormonal cancers and other cancers. Many types of research on biochanin-A, particularly in breast, lung, colon, prostate, and pancreatic cancers, have shown a positive impact. Through modulating oxidative stress, SIRT-1 expression, PPAR gamma receptors, and other multiple mechanisms biochanin-A produces anti-diabetic action. The diverse molecular mechanistic pathways involved in the pharmacological ability of biochanin-A indicate that it is a very promising molecule and can play a major impact in modifying several physiological functions.

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Section: Biochanin-a and Its Pharmacological Benefitsmentioning

confidence: 86%

Mechanisms Behind the Pharmacological Application of Biochanin-A: A review

Anuranjana,

Beegum,

K.P

et al. 2023

F1000Res

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“…Moreover, BCA significantly downregulates promoter I.3 and II transactivation in MCF‐7 and SK‐BR‐3 breast cancer cells (Wang et al, 2008). The amounts of CD38 and CD44 were markedly reduced after BCA treatment in melanoma (Jaina et al, 2022). A molecular mechanism and summary of BCA‐mediated anticancer properties is summarized in Figure 5 and Table 2, respectively.…”

Section: Anticancer Perspectives Of Bcamentioning

confidence: 99%

“…CD44 and HA contribute to drug resistance by activating PI3K signaling and activating the MDR transporter (Wang, Zhao, et al, 2018). However, BCA treatment in vitro and in vivo models ameliorated cancerous properties, including tumorgenicity, stemness, and invasion, by mitigating the CD38 and CD44 levels in multiple myeloma (Jaina et al, 2022). Furthermore, BCA can inhibit the PI3K/AKT signaling activity in U251 cells in glioma therapy and disrupt the ERK, MAPK, and PI3K/AKT pathways in liver cancer (Jain et al, 2015; Xiao et al, 2020).…”

Section: Power Of Bca In Alleviating Multidrug Resistance In Numerous...mentioning

confidence: 99%

Comprehensive exploration of Biochanin A as an oncotherapeutics potential in the treatment of multivarious cancers with molecular insights

Sohel

2023

Phytotherapy Research

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Cancer is considered a leading cause of mortality. This rising cancer death rate and several existing limitations like side effects, poor efficacies, and high cost of the present chemotherapeutic agents have increased the demand for more potent and alternative cancer treatments. This review elucidated a brief overview of Biochanin A (BCA) and its potentiality on various cancers with details of anticancer mechanism. According to our review, a number of studies including in silico, in vitro, pre‐clinical, and clinical trials have tested to evaluate the efficacy of BCA. This compound is effective against 15 types of cancer, including breast, cervical, colorectal, gastric, glioblastoma, liver, lung, melanoma, oral, osteosarcoma, ovarian, pancreatic, pharynx, prostate, and umbilical vein cancer. The general anticancer activities of this compound are mediated via several molecular processes, including regulation of apoptosis, cell proliferation, metastasis and angiogenesis, signaling, enzymatic pathways, and other mechanisms. Targeting both therapeutic and oncogenic proteins, as well as different pathways, makes up the molecular mechanism underlying the anticancer action. Many signaling networks and their components, such as EFGR, PI3K/Akt/mTOR, MAPK, MMP‐2, MMP‐9, PARP, Caspase‐3/8/9, Bax, Bcl2, PDL‐1, NF‐κB, TNF‐α, IL‐6, JAK, STAT3, VEGFR, VEGF, c‐MY, Cyclin B1, D1, E1 and CDKs, Snail, and E‐cadherin proteins, can be regulated in cancer cells by BCA. Such kind of anticancer properties of BCA could be a result of its correct structural chemistry. The use of BCA‐based therapies as nano‐carriers for the delivery of chemotherapeutic medicines has the potential to be very effective. This natural compound synergises with other natural compounds and standard drugs, including sorafenib, 5‐fluorouracil, temozolomide, doxorubicin, apigenin, and genistein. Moreover, proper use of this compound can reverse multidrug resistance through numerous mechanisms. BCA has better drug‐likeness and pharmacokinetic properties and is nontoxic (eye, liver, kidney, skin, cardio) in human bodies. As having a wide range of cancer‐fighting mechanisms, synergistic effects, and good pharmacokinetic properties, BCA can be used as a supplementary food until standard drugs are available at pharma markets.

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“…It owes its high protein content to its microflora, which includes bacteria capable of fixing atmospheric nitrogen and their symbiosis with the soil microflora. Red clover occurs naturally in Europe, West Asia and northwest Africa, but is grown in many parts of the world due to its high adaptability to different soils [2,4,5].…”

Section: Introductionmentioning

confidence: 99%

Optimization of the Extraction Conditions of Polyphenols from Red Clover (Trifolium pratense L.) Flowers and Evaluation of the Antiradical Activity of the Resulting Extracts

Drużyńska,

Łukasiewicz,

Majewska

et al. 2024

Antioxidants

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The purpose of this study was to analyze the effect of the type of extraction solution (water, different concentrations of ethanol), temperature and time on the polyphenol content and antioxidant properties of red clover extracts and the effect of the addition of selected extracts on the antioxidant properties of enriched blackcurrant beverages. In both the extractions carried out under different conditions and in the enriched beverages, the content of selected polyphenols was determined by HPLC. This study confirmed the significant effect of the alcohol content of the extract, extraction time and temperature on the antioxidant properties of clover extracts. Ethanolic extracts had better antioxidant properties than aqueous extracts. The addition of ethanol extracts had a significant effect on the antioxidant properties of the fortified beverages. Increasing the temperature, time or ethanol content in the extracts mostly resulted in an increase in the total polyphenol content in the obtained extracts. Based on the analysis of the response surface, it was found that for the DPPH radical, the best activity was obtained by extraction for 20 min with a solution of approximately 65% at low temperatures. In the case of the ABTS radical, the best antiradical activity was obtained after extraction for 60 min at 80 °C with a solution of approximately 50% ethanol. It was also found that the use of a solution of approximately 60% ethanol after extraction for 60 min at 80 °C would provide an extract with high antiradical activity against both radicals.

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Anti-cancer activity of Biochanin A against multiple myeloma by targeting the CD38 and cancer stem-like cells

Cited by 14 publications

References 51 publications

Mechanisms Behind the Pharmacological Application of Biochanin-A: A review

Mechanisms Behind the Pharmacological Application of Biochanin-A: A review

Comprehensive exploration of Biochanin A as an oncotherapeutics potential in the treatment of multivarious cancers with molecular insights

Optimization of the Extraction Conditions of Polyphenols from Red Clover (Trifolium pratense L.) Flowers and Evaluation of the Antiradical Activity of the Resulting Extracts

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