Anti-Cancer Activity of Methanol Extracts of Cichorium Intybus on Human Breast Cancer SKBR3 Cell Line

Mehrandish, Reza; Mellati, Ali Awsat; Rahimipour, Ali; Nayeri, Nasrin Dehghan

doi:10.17795/rijm38369

Cited by 6 publications

(8 citation statements)

References 11 publications

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“…These results were cited with other types of cancer cell line. The cytotoxic activity of C. intybus against Ehrlich ascites carcinoma cells (EACC) and SKBR3 cell Line has been studied (Al-Snafi, 2016;Conforti et al, 2008;Guide, 2002;Mehrandish, Mellati, Rahimipour, & Nayeri, 2017), as well, the aqueous extract of chicory can induce caspase-3 activation (Nawab, Yunus, Mahdi, & Gupta, 2011).…”

Section: Discussionmentioning

confidence: 99%

Cytotoxic profile activities of ethanolic and methanolic extracts of chicory plant (Cichorium intybus L.)

Kandil

Abou-Elella

Shemy

2019

Journal of Radiation Research and Applied Sciences

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Section: Discussionmentioning

confidence: 99%

Cytotoxic profile activities of ethanolic and methanolic extracts of chicory plant (Cichorium intybus L.)

Kandil

Abou-Elella

Shemy

2019

Journal of Radiation Research and Applied Sciences

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“…In our previous study, we investigated the cytotoxicity effect of Cichorium intybus extract on cell viability of SKBR3 cells, using MTT assay (14). As can be seen in Figure 1, the results of this study showed that Cichorium intybus extract decreases the cell viability of SKBR3 cells in a timeand concentration -dependent manner.…”

Section: Inhibitory Effect Of Cichorium Intybus Extract On Cell Viabimentioning

confidence: 71%

Inhibitory Effects of Cichorium Intybus Root Extract on the Proliferation and Lipogenesis of the SKBR3 Cells

et al. 2018

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Background: Fatty acid synthase (FASN) is a key enzyme in de novo lipogenesis pathway. FASN overexpression is a common feature of many human cancers like breast cancer. Furthermore, FASN expression in HER2 -positive cell lines like SKBR3 is more than other cell lines, such as MCF -7, which are not HER2 -positive. Cichorium intybus is a medicinal herb and methanolic extract of this plant significantly suppressed cell viability and growth in some cancer cells. Objectives: In this study, we aimed at investigating the effect of methanolic extract of Cichorium intybus on the FASN expression and, therefore, lipogenesis pathway in human breast cancer SKBR3 cell line. Methods:We assessed the cytotoxicity effect of Chicorium intybus on the cell viability of SKBR3 cells, using MTT assay. In addition, apoptosis rate was assessed by annexinV/PI flow cytometry. Finally, Real time q -PCR was used for the analysis of FASN gene expression. Results:The results showed that the methanolic extract of Cichorium intybus caused a dose -dependent decrease in the cell viability of SKBR3 cells. Additionally, the treatment of confluent SKBR3 cells with extract led to reduced FASN expression at mRNA level. Conclusions: These results suggest that Chicorium intybus not only inhibits cell viability in a dose -dependent manner, but also presumably inhibits lipogenesis by markedly decreased FASN expression as a key lipogenic enzyme.

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“…A comparative study between different plants showed that C. intybus seed water extract moderately reduced the development and colony formation in PC-3 prostate cancer cells (2-30%), T47D breast carcinoma cells (2-21%), and RKO (17). A methanolic extract of C. intybus decreased the viability of breast cancer cells (SKBR3) in a time-dependent manner with an IC 50 of 800, 400 and 300 µg/ml at 24, 48, and 72 h treatment, respectively (18). The n-hexane extract of the aerial part demonstrated significant antiproliferative (70% at 100 µg/ml) as well as cytotoxic activity (50.3% at 100 µg/ml) against lymphocytic leukemia Jurkat cells (19).…”

Section: Antitumor Activity Of the Phytochemicalsmentioning

confidence: 99%

“…The antitumor property of flavonoids is partly due to their ability to counteract fatty acid synthase (FASN). Cancerous cells have an elevated metabolic rate compared with healthy cells, which enables cancer cells to grow and proliferate at a faster rate (18). Rapid cell division often leaves trails of both biochemically and structurally irregular cells.…”

Section: Molecular Mechanismsmentioning

confidence: 99%

Cytotoxicity of Cichorium intybus L. metabolites (Review)

et al. 2019

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Cichorium intybus L. (Chicory) is a widely distributed, edible, perennial, herbaceous member of the Asteraceae family. Besides its use in modern Chinese herbal medicine, its ethnomedicinal use is evident in the text from ancient Greece, Egypt and China. It is also used as a food and coffee substitute, which is mainly responsible for its extensive domestication. In recent decades, cytotoxic studies of C. intybus extracts have shown its antitumor potential. These studies also identified metabolite constituents including guaianolides, 6-methoxyflavone, eudesmanolides, germacranolides, polyacetylene, sterol, anthocyanin, delphinidin, 3,4-dihydroxyphenethyl and other novel compounds. Many of these phytometabolites have shown positive cytotoxic activities in vitro, and antitumor action in vivo and in clinical trials, demonstrating the potential of C. intybus metabolites as antitumor drugs. Structural activity relationship studies have further confirmed these bioactivities. In this review, we focused on the phytochemicals of C. intybus with reported cytotoxicity and potential antitumor properties. We also discuss their specificity towards tumor cells, structural activity relationship, the involved signaling pathways and molecular mechanism, with the expectation of the future development of efficient and targeted antitumor therapeutic strategies.

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Anti-Cancer Activity of Methanol Extracts of Cichorium Intybus on Human Breast Cancer SKBR3 Cell Line

Cited by 6 publications

References 11 publications

Cytotoxic profile activities of ethanolic and methanolic extracts of chicory plant (Cichorium intybus L.)

Cytotoxic profile activities of ethanolic and methanolic extracts of chicory plant (Cichorium intybus L.)

Inhibitory Effects of Cichorium Intybus Root Extract on the Proliferation and Lipogenesis of the SKBR3 Cells

Cytotoxicity of Cichorium intybus L. metabolites (Review)

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