Cytotoxic profile activities of ethanolic and methanolic extracts of chicory plant (Cichorium intybus L.)

Kandil, Abeer S.; Abou-Elella, Faten; Shemy, Hany A. El

doi:10.1080/16878507.2019.1594136

Cited by 14 publications

(12 citation statements)

References 34 publications

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“…Both phenolic acids and flavonoids are known as antioxidant compounds, but their ability depends not only on the quantities but on the chemical structure also [ 52 ]. The DPPH radical scavenging activity of the extracts was modest (164.98 ± 5.93 µg/mL for the CHME and 336.35 ± 11.77 µg/mL for the CHT), but in accordance with other data [ 53 ]. Previous studies have reported even higher values (over 700 µg/mL), while several authors have obtained a better antioxidant activity for the hydroalcoholic extract of chicory leaves [ 54 ].…”

Section: Resultssupporting

confidence: 89%

Phytochemical Profile, Antioxidant, Cardioprotective and Nephroprotective Activity of Romanian Chicory Extract

Epure

Pârvu

Vlase

et al. 2020

Plants

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The present study analyzed the methanol extract and tincture obtained from the spontaneous Romanian Cichorium intybus species, in order to evaluate polyphenols content and some biological properties. Chromatographic and spectrophotometric methods were used for the analysis of polyphenols and the antioxidant capacity was assessed in vitro with DPPH● (2,2-diphenyl-picrylhydrazil) and FRAP (ferric-reducing antioxidant power) tests. The cardio-protective effects of Cichorii herba tincture on myocardial ischemia induced by isoprenaline and nephroprotection on renal failure induced by gentamicin were evaluated on rats. Also, aspartate aminotrasferase (AST), alanine aminotransferase (ALT), creatine kinase-MB (CK-MB) and creatinine clearance (CrCl) were measured. The antioxidant effect was evaluated by determining total oxidative stress (TOS), oxidative stress index (OSI, total antioxidant capacity (TAC), malondyaldehide (MDA), total thiols (SH) and total nitrites and nitrates (NOx). Cichoric acid was the main polyphenolic compound. The extracts had moderate in vitro antioxidant activity but the in vivo antioxidant and anti-inflammatory effects were significant and associated with myocardial and renal dysfunction improvement. The results were attributed to the content of polyphenols in the extracts, for which reason C. intybus may be considered an important raw material for pharmaceuticals formulations recommended in the prevention or treatment of heart or kidney diseases.

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Section: Resultssupporting

confidence: 89%

Phytochemical Profile, Antioxidant, Cardioprotective and Nephroprotective Activity of Romanian Chicory Extract

Epure

Pârvu

Vlase

et al. 2020

Plants

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“…A good correlation was observed between total phenolic content and antioxidant activity. It is observed from the results of this study that the highest phenolic and flavonoid content of chicory extracts exhibited high antioxidant activities (Kandil et al,2019). The higher DPPH antioxidant activity in methanolic extract of Cichorium intybus L. is significantly higher than that of other solvents (p >0.05).…”

Section: Antioxidant Activity By Dpphmentioning

confidence: 61%

“…Eray et al,(2020) reported total flavonoid content in herbal parts of Cichorium intybus L.water extract range about 388.3±5.77 μg CE/mg, and methanolic extract range about 550±14.53 μg CE/mg. Also, our results were the lowest of these studies.On the other hand, Kandil et al,(2019) reported that the total flavonoid content of Cichorium intybus L. in methanolic extract range about 167.47 ± 5.83 μg QE/g,whiles in ethanolic extract range about 36.56 ± 5.95 μg QE/g.Our results were the higher of these studies.Also,the assessment flavonoid in EtOAc extracts does not have any previously publication results (EtOAc=No).…”

Section: Total Flavonoids Contentmentioning

confidence: 98%

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EFFECT OF EXTRACTION SOLVENT ON BIOACTIVE COMPOUNDS AND ANTIOXIDANT ACTIVITY OF Cichorium intybus L. GROWN IN KOSOVO

Koraqi¹,

LLUGA-RIZANI²

2022

AgricultForest

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The aim of this study was the investigation of the total phenolic content, flavonoid, and the assessment of the antioxidant potential of Cichorium intybus L. flowers grown in the Kosovo region. The flowers of Cichorium intybus L. were collected, dried, and extracted with solvents with different polarities (water, EtOH, MeOH, EtOAc, and acetone), using the extraction method. The total phenolic and flavonoid contents were analyzed by using Folin-Ciocalteu's and AlCl3 reagents, respectively. The antioxidant activity was assessed by DPPH in vitro assay methods. The obtained results revealed variation in the content of phenolic compounds (5.2 mg GAE/gDW in water extract, 6.8 mg GAE/gDW in ethanolic extract,72.1 0.3 mg GAE/gDW in methanolic extract, 45.3 0.1 mg GAE/g DW in ethyl acetate extract,and 31.3 0.1 mg GAE/gDW in acetone extract), flavonoid (2.9 mg CE/gDW in water extract, 19.0 mg CE/gDW in ethanolic extract,30.50 mg CE/gDW in methanolic extract, 27.1 mg CE/gDW in ethyl acetate extract, and 25.4 mg CE/gDW in acetone extract), and antioxidant activity (23.0 μMolTE/gDW in water extract, 124.7 μMolTE/gDW in ethanolic extract, 152.4 μMolTE/gDW in methanolic extract, 92.7 μMolTE/gDW in ethyl acetate extract,and 107.2 μMolTE/gDW in acetone extract). Cichorium intybus L. flowers from the Kosovo region are also a rich source of flavonoids. Further studies are recommended to quantify and isolate the pure phytoconstituents from Cichorium intybus L. flowers grown in the Kosovo region which might serve as natural antioxidants application in the food and drug industry.

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“…C. intybus has been assessed as an in vitro antiproliferative activity against prostate cancer (LNCaP), amelanotic melanoma (C32), and renal adenocarcinoma (ACHN) cell lines (Mohammad et al, 2014). Additionally, crude methanolic extract of chicory exerted a potent cytotoxic activity (90%) against MCF-7 and AML-7 cell lines at 500 µg/mL (Kandil et al, 2019).…”

Section: Advances In Animal and Veterinary Sciencesmentioning

confidence: 99%

Antioxidant, Hepatoprotective and In vitro Cytotoxic Activities of Cichorium intybus L. Extract

Atef¹,

El-Gendi²,

Amer³

et al. 2020

AAVS

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Cytotoxic profile activities of ethanolic and methanolic extracts of chicory plant (Cichorium intybus L.)

Abstract: View related articles View Crossmark data Cytotoxic profile activities of ethanolic and methanolic extracts of chicory plant (Cichorium intybus L.

Cited by 14 publications

References 34 publications

Phytochemical Profile, Antioxidant, Cardioprotective and Nephroprotective Activity of Romanian Chicory Extract

Phytochemical Profile, Antioxidant, Cardioprotective and Nephroprotective Activity of Romanian Chicory Extract

EFFECT OF EXTRACTION SOLVENT ON BIOACTIVE COMPOUNDS AND ANTIOXIDANT ACTIVITY OF Cichorium intybus L. GROWN IN KOSOVO

Antioxidant, Hepatoprotective and In vitro Cytotoxic Activities of Cichorium intybus L. Extract

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