Anti-Cancer Activity of Methanol Extracts of Cichorium Intybus on Human Breast Cancer SKBR3 Cell Line

Mehrandish, Reza; Mellati, Ali Awsat; Rahimipour, Ali; Nayeri, Nasrin Dehghan

doi:10.5812/rijm.38369

Cited by 10 publications

(7 citation statements)

References 11 publications

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“…STL alone seems to be responsible for one important apoptosis-related gene expression, and this observation could be associated with in vitro results (Figure 8), showing a significant apoptotic effect of STL on HepG2 cells. Our observations are consistent with other studies showing the effect of chicory extracts on the regulation of cell proliferation and apoptosis in different human cancer cell lines [42,43].…”

Section: The Anti-cancer Effect Of the Chicory Roots As Observed In A...supporting

confidence: 93%

Chicory: Understanding the Effects and Effectors of This Functional Food

et al. 2022

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Industrial chicory has been the subject of numerous studies, most of which provide clinical observations on its health effects. Whether it is the roasted root, the flour obtained from the roots or the different classes of molecules that enter into the composition of this plant, understanding the molecular mechanisms of action on the human organism remains incomplete. In this study, we were interested in three molecules or classes of molecules present in chicory root: fructose, chlorogenic acids, and sesquiterpene lactones. We conducted experiments on the murine model and performed a nutrigenomic analysis, a metabolic hormone assay and a gut microbiota analysis, associated with in vitro observations for different responses. We have highlighted a large number of effects of all these classes of molecules that suggest a pro-apoptotic activity, an anti-inflammatory, antimicrobial, antioxidant, hypolipidemic and hypoglycemic effect and also an important role in appetite regulation. A significant prebiotic activity was also identified. Fructose seems to be the most involved in these activities, contributing to approximately 83% of recorded responses, but the other classes of tested molecules have shown a specific role for these different effects, with an estimated contribution of 23–24%.

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Section: The Anti-cancer Effect Of the Chicory Roots As Observed In A...supporting

confidence: 93%

Chicory: Understanding the Effects and Effectors of This Functional Food

et al. 2022

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“…Chicory plant has exhibited antifungal properties; nevertheless, the plant's root methanol extract has been reported to have anti-cancer properties by the presence of various classes of compounds, such as lactucin, β-sitosterol, quinic acid, succinic acid, and polyphenols such as flavonoids in the root methanol extracts [70,72]. Flavonoids have been identified to have anti-cancer properties due to the compound's ability to inhibit fatty acid synthase enzyme, which over-express and are highly active in cancer cells.…”

Section: Anti-cancer and Anti-tumor Activitymentioning

confidence: 99%

“…Flavonoids have been identified to have anti-cancer properties due to the compound's ability to inhibit fatty acid synthase enzyme, which over-express and are highly active in cancer cells. From one study, it was found that the methanol root extract of chicory plant was able to reduce the viability of the human breast cancer SKBR3 cell line at concentrations of 400 µg/mL, 500 µg/mL, and 600 µg/mL, in a time-and concentration-dependent manner [70]. As the dose of the chicory methanol extract concentration and time duration of the exposure increases, the percentage of breast cancer cell viability decreases, thus indicating the applicability of chicory root methanol extract for anti-cancer treatment.…”

Section: Anti-cancer and Anti-tumor Activitymentioning

confidence: 99%

Middle Eastern Plant Extracts: An Alternative to Modern Medicine Problems

et al. 2020

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Middle Eastern countries are primarily known for their dry sand deserts; however, they have a wider physiographic range which includes upland plateau and mountain ranges. The Middle East is home to various types of plants, such as Phoenix dactylifera (date palm tree), Scrophularia striata (herbaceous plants), and Opuntia ficus-indica (cactus). These plants have been found to have various types of bioactivities, such as antimicrobial activities against both bacteria and fungi, in addition to exhibiting anti-inflammatory effects and anti-cancer characteristics which can be utilized in the clinical setting for treatment. Due to limited reviews focusing on plant extracts from the Middle East, we aim to provide a discourse on plants from this region which have various bioactivities and to provide information on the compounds that can be identified from these plants. This is to enhance our understanding to improve modern medicine problems such as antimicrobial resistance and to find an alternative cure for cancer. It is hoped that the collation of information from this review will enable an assessment of the direct role of Middle Eastern plants in providing therapeutic options to address the predicaments in the medical field.

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“…Cichorium intybus is a plant traditionally used as food and medicinal crop in temperate parts of the old world 7,8 and as carminative, and against other cardiac ailments as well. 9 Chicory has been found to be a potential anti-cancer, 10 anti-malarial, antimicrobial 11 , anti-diabetic 12 and is considered as a potent source of natural antioxidants 13 . Chicory has also been found to be very effective in case of severe jaundice, gout, asthma, and rheumatic conditions.…”

Section: Introductionmentioning

confidence: 99%

“…This solution (1 ml) was added to 1 ml. of different concentrations(1,5,10, 15,20,25, 30, 35, 40, 45, 50 µg/ml) of extracts in methanol.…”

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confidence: 99%

Screening of Antioxidant, Antimicrobial and Phytochemicals Composition of Various Plant Parts of Cichorium Intybus

Maitry

Priyanka

Sharma

2022

Int J Life Sci Pharm Res

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The present study was conducted to evaluate the antioxidant and antimicrobial potential as well as the phytochemical composition of root, seed and leaves of Cichoriumintybus. The antioxidant activity was analyzed by detecting the 2, 2-Diphenyl-1- picrylhydrazyl DPPH radical scavenging potent of the constituents found in various plant parts of Cichorium intybus,whereas for analyzing in-vitro antimicrobial activity, agar well diffusion method has been opted. The antimicrobial activity of plant was tested against both pathogenic as well as non-pathogenic species of bacteria by analyzing the corresponding inhibition zone exhibited by various extracts of plant parts against the bacterial growth. Apart from this, the present study also involves the quantitative phytochemical evaluation of total ascorbic acid in root, seed and leaves of Cichoriumintybus. The antioxidant potential of the plant was found to be comparatively lower in seed and leaves of plant than in root in accordance to the determined IC50 value . From the antimicrobial activity analysis, it was concluded that majority of times the non-polar extracts of all plant parts were found to be more effective in inhibiting growth of bacteria. Most significant activity has been exhibited against gram negative bacteria Pseudomonas aeruginosa. The ascorbic acid content in plant was found in the range of 2.253±0.867 to 12.594±2.05µg/ml. From the results of the conducted research, the importance of plant as an antimicrobial and anti-oxidative agent has been established. So, the plant can further be introduced as a potential drug for herbal medicine in the treatment of human disorders.

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Anti-Cancer Activity of Methanol Extracts of Cichorium Intybus on Human Breast Cancer SKBR3 Cell Line

Cited by 10 publications

References 11 publications

Chicory: Understanding the Effects and Effectors of This Functional Food

Chicory: Understanding the Effects and Effectors of This Functional Food

Middle Eastern Plant Extracts: An Alternative to Modern Medicine Problems

Screening of Antioxidant, Antimicrobial and Phytochemicals Composition of Various Plant Parts of Cichorium Intybus

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