Anti-Cancer Effects and Mechanisms of Capsaicin in Chili Peppers

Abstract

Cancer is a major cause of morbidity and mortality all over the world and a promising area of cancer research is concentrated on chemoprevention by nutritional compounds. Capsaicin, traditionally used as a food additive and an analgesic, is one of the main pungent ingredients in chili peppers. Recent studies have shown that capsaicin has anti-cancer effects in various types of cancer model. The purpose of this review is to outline the anticarcinogenic effect of capsaicin and its mechanism.

Thermal Degradation Kinetics of Capsaicin on Blanching-Brine-Calcium Pretreatment Red Chili Pepper Drying

“…The pungent sensation of red chili pepper is due to existence of bioactive compound called capsaicin and its capsaicinoid analogs [1][2][3]. Capsaicin (trans-8-methyl-N-vanillyl-6-nonenamide) is fat-alcohol-oil soluble, colorless, crystalline and odorless [4][5][6]. It also is a major compound of capsaicinoids (alkaloid) that are widely applied in pharmaceutical and clinical product [7].…”

Improved Sensing of Capsaicin with TiO2 Nanoparticles Modified Epoxy Graphite Electrode

“…Chemically, capsaicin is trans-8-methyl-N-vanillyl-6-nonenamide; it's handbook description is: fat soluble, odourless, pungent tasting, offwhite solid with a melting point of 62-65°C and a molecular weight of 305.4 g mol À 1 Besides its usage in food preparations, capsaicin has also application in pharmaceutical industry due to its several pharmacological properties [5][6][7]. It is well-known to have anti-bacterial [8], anti-carcinogenic [9], antitumoral [10], anti-mutagenic [11] properties and it is a good anti-oxidant [12]. Capsaicin is also used as an ingredient in drugs to control obesity [13], cholesterol [14] and in topical formulations used for pain management [15][16].…”

“…Besides its usage in food preparations, capsaicin has also application in pharmaceutical industry due to its several pharmacological properties . It is well‐known to have anti‐bacterial , anti‐carcinogenic , anti‐tumoral , anti‐mutagenic properties and it is a good anti‐oxidant . Capsaicin is also used as an ingredient in drugs to control obesity , cholesterol and in topical formulations used for pain management .…”

Conditions de synergie d’action des extraits anti-radicalaires de <i>Flueggea virosa</i> (Roxb. Ex Wild.) Royle et de <i>Crataeva adansonii</i> Forst. f. avec inductions acido-basiques extérieures

“…Dans la littérature scientifique, les effets bénéfiques des antioxydants dans l'organisme humain ainsi que leur grande utilisation dans l'industrie agroalimentaire, sont beaucoup décrits et documentés (Poaty-Poaty, 2009;Cao et al, 2015). Ainsi, la recherche de molécules antioxydantes a connu un essor sans précédent pour des utilisations, entre autres, dans les industries agroalimentaires, en phytothérapie ou en médecine (Maloueki et al, 2015).…”