Anti-cancer mechanisms of linalool and 1,8-cineole in non-small cell lung cancer A549 cells

Rodenak-Kladniew, Boris; Castro, Mariana N.; Crespo, Rosana; Galle, Marianela; Bravo, Margarita María García de

doi:10.1016/j.heliyon.2020.e05639

Cited by 49 publications

(39 citation statements)

References 60 publications

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“…ROS were involved in cell growth inhibition and mitochondrial depolarization. Linalool increased ROS production and MMP depolarization [18] . To investigate the mechanism of anti-tumorigenic potential of linalool, we studied its effect on KB cells in terms of oxidative stress.…”

Section: Resultsmentioning

confidence: 99%

Linalool Induces Reactive Oxygen Species Mediated Apoptosis in Human Oral Squamous Carcinoma Cells

Pushpalatha¹,

Sindhu²,

Sharmila³

et al. 2021

ijps

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Section: Resultsmentioning

confidence: 99%

Linalool Induces Reactive Oxygen Species Mediated Apoptosis in Human Oral Squamous Carcinoma Cells

Pushpalatha¹,

Sindhu²,

Sharmila³

et al. 2021

ijps

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“…Pachymic acid induced apoptosis via activating ROS-dependent JNK and ER stress pathways in lung cancer cells [43]. Linalool inhibited A549 cell migration and induced cell growth inhibition and mitochondrial depolarization [44].…”

Section: Discussionmentioning

confidence: 99%

Network Pharmacology and Experiment Verification to Explore the Potential Mechanism of Yin-Huo-Tang for Lung Adenocarcinoma Recurrence

Liu

Lin

et al. 2021

Preprint

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BackgroundLung adenocarcinoma (LUAD) is one of the most common malignancies with a rise in new cases worldwide each year. Recurrence significantly influences the survival in patients with LUAD. Yin-Huo-Tang (YHT) is a classic traditional Chinese prescription, used to prevent lung cancer relapse by “nourishing yin and clearing heat”. MethodsIn this study, the mechanism of YHT in LUAD recurrence was investigated. Firstly, the bioactive compounds-targets network and the protein–protein interaction network were constructed, and functional annotation and pathway enrichment analyses were performed. Pivotal compounds and hub genes were selected from the networks. Subsequently, the effectiveness of YHT was confirmed in lewis lung carcinoma mice. RNA sequencing was used to explore the mRNA expression differences between tumor tissues in the model mouses and YHT-treated mouses. The pathways screened by network pharmacology and RNA sequencing analysis at the same time were considered the most important pathways. At last, qualitative phytochemical analysis, molecular docking technology, PCR and WB analysis were used to validate the pivotal active ingredients, hub genes and main pathways.ResultsThere were 128 active compounds, 419 targets interacting with LUAD recurrence. Network analysis identified 4 pivotal compounds, 28 hub genes and 30 main pathways. Target genes mainly focused on inflammation, metabolism, immune responses and apoptosis. We confirmed that YHT could inhibit the recurrence of lung adenocarcinoma through animal experimental study. Sphingolipid signaling pathway was the common main pathway in network pharmacology and RNA sequencing results. The hub genes related with the sphingolipid signaling pathway was S1PR5. Qualitative phytochemical analysis of the water extract of YHT confirmed the presence of 3 pivotal compounds, namely stigmasterol, nootkatone and ergotamine. The results of molecular docking verified the pivotal compounds of YHT could good affinity with the S1PR5. The PCR and WB analysis verified YHT suppressed lewis lung cancer cells proliferation by inhibiting S1P/S1PR5/Gi/Ras/Raf/MEK/ERK pathway, and inhibited migration through S1P/S1PR5/Gi/PI3K/RAC pathway.ConclusionThe results confirmed the therapeutic effect of YHT on the recurrence of LUAD by multi-component-multi-target mode, the sphingolipid signaling pathway was one of the most relevant potential signaling pathways.

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“…Eucalyptol (1,8-cineole) was the main compound identified in Turnera diffusa essential oils, in concentrations up to 17.20%. This compound is a cyclic-ether monoterpene also found in several plants such as eucalyptus, rosemary, sage, bay, cinnamon, and tea [65]. In addition, this compound has been reported for its pharmacological properties, including analgesic [66], insecticidal [67], sedative [68], antioxidant [69], anti-inflammatory [70,71], bactericidal [72], fungicidal [73], hypolipidemic [74], and anticancer activities [75].…”

Section: The Most Important Compounds Identified and Their Propertiesmentioning

confidence: 99%

Currently Applied Extraction Processes for Secondary Metabolites from Lippia turbinata and Turnera diffusa and Future Perspectives

2021

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The poleo (Lippia turbinata Griseb.) and damiana (Turnera diffusa Wild) are two of the most valued species in the Mexican semidesert due to their medicinal uses. The conventional essential oil extraction process is hydrodistillation, and for the extraction of antioxidants, the use of organic solvents. However, these techniques are time-consuming and degrade thermolabile molecules, and the efficiency of the process is dependent on the affinity of the solvent for bioactive compounds. Likewise, they generate solvent residues such as methanol, hexane, petroleum ether, toluene, chloroform, etc. Therefore, in recent years, ecofriendly alternatives such as ohmic heating, microwaves, ultrasound, and supercritical fluids have been studied. These methodologies allow reducing the environmental impact and processing times, in addition to increasing yields at a lower cost. Currently, there is no up-to-date information that provides a description of the ecofriendly trends for the recovery process of essential oils and antioxidants from Lippia turbinata and Turnera diffusa. This review includes relevant information on the most recent advancements in these processes, including conditions and methodological foundation.

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Anti-cancer mechanisms of linalool and 1,8-cineole in non-small cell lung cancer A549 cells

Cited by 49 publications

References 60 publications

Linalool Induces Reactive Oxygen Species Mediated Apoptosis in Human Oral Squamous Carcinoma Cells

Linalool Induces Reactive Oxygen Species Mediated Apoptosis in Human Oral Squamous Carcinoma Cells

Network Pharmacology and Experiment Verification to Explore the Potential Mechanism of Yin-Huo-Tang for Lung Adenocarcinoma Recurrence

Currently Applied Extraction Processes for Secondary Metabolites from Lippia turbinata and Turnera diffusa and Future Perspectives

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