Anti-Candida activity of the water-soluble lectin from Moringa oleifera seeds (WSMoL)

Santos, Leilane Marina Morais dos; Silva, P.M.; Moura, Márcio das Chagas; Carvalho, Alexsander Rodrigues; Amorim, Poliana Karla; Procópio, Thamara Figueiredo; Coelho, Luana Cassandra Breitenbach Barroso; Silva, L.C.N.; Santos, Nataly Diniz de Lima; Napoleão, Thiago Henrique

doi:10.1016/j.mycmed.2020.101074

Cited by 23 publications

(12 citation statements)

References 23 publications

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“…WSMoL, lectina solúvel em água de sementes de Moringa oleifera, obteve resultados positivos para atividade antifúngica contra espécies do gênero Candida. Essa proteína inibiu o crescimento de C. albicans, C. glabrata, C. krusei e C. parapsilosis, com CIM de 20 µg/ mL, além disso a concentração fugicida mínima foi de 20 µg/mL para C. glabrata e 80 µg/mL para C. albicans e C. parapsilosis [25]. A inibição do crescimento começou a ocorrer a partir da nona à décima hora de incubação para todas as cepas utilizadas.…”

Section: Atividade Antifúngica De Lectinas Extraídas De Plantasunclassified

“…Também foram observadas células apoptóticas, com maior intensida-de para C. krusei. A apoptose tardia ou necrose foi confirmada para C. krusei e C. glabrata, enquanto em C. parapsilosis foi observado a existência de células bastante danificadas [25]. Os resultados demonstram que WSMoL teve atividade antifúngica diferente de acordo com as espécies.…”

Section: Atividade Antifúngica De Lectinas Extraídas De Plantasunclassified

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ATIVIDADES BIOTECNOLÓGICAS DAS LECTINAS DE Bauhinia forficata: PLANTA COM EFEITO HIPLOGLICÊMICO

Aguiar¹,

Santos²,

Santos³

et al. 2022

Plantas Medicinais E Fitoterápicos

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As lectinas são um grupo de proteínas que possuem como característica principal a capacidade de estabelecer interações específica e reversivelmente a carboidratos. O objetivo deste trabalho foi realizar um levantamento bibliográfico acerca das atividades biotecnológicas das lectinas da espécie Bauhinia forficata, tradicionalmente utilizada na medicina popular por suas propriedades hipoglicemiantes, inclusive é uma das espécies listadas como de interesse ao SUS. Foi realizada busca por artigos científicos no Google Acadêmico, estabelecendo-se como recorte temporal o período de 2000 a 2020. Alguns descritores foram estabelecidos, e os artigos foram escolhidos conforme a relevância. Duas lectinas de B. forficata foram purificadas e caracterizadas, e há trabalhos que relatam estudos com proteínas recombinantes devido à dificuldade de se trabalhar com a forma natural. Dentre as potencialidades biotecnológicas para B. forficata está sua ação anticâncer, tendo sido registrada sua eficácia contra várias linhagens de células cancerígenas, como melanoma, câncer de mama e colorretal.

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Section: Atividade Antifúngica De Lectinas Extraídas De Plantasunclassified

ATIVIDADES BIOTECNOLÓGICAS DAS LECTINAS DE Bauhinia forficata: PLANTA COM EFEITO HIPLOGLICÊMICO

Aguiar¹,

Santos²,

Santos³

et al. 2022

Plantas Medicinais E Fitoterápicos

View full text Add to dashboard Cite

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“…Os resultados demonstram que WSMoL teve atividade antifúngica diferente de acordo com as espécies. Os efeitos de indução a apoptose de WSMoL nas espécies de Candida foi conferido à disfunção mitocondrial, desde que a lectina foi capaz de induzir a despolarização do potencial transmembrana [25]. Os mecanismos celulares para estes resultados ainda não foram elucidados.…”

Section: Atividade Antifúngica De Lectinas Extraídas De Plantasunclassified

Fitoterapia Aplicada Ao Controle De Obesidade: Uma Breve Revisão

Silva¹,

Bernardo²,

Macena³

et al. 2022

Plantas Medicinais E Fitoterápicos

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“…However, until now, there are currently no reported scientific findings on the potential effects of MOSE on fertility and pregnancy outcome. Yet the application of lipid-rich Moringa whole seed as well as the aqueous extracts of MOSE (containing suspended lipids) as an anti-infective and restorative nutraceutical ( Xiong et al, 2020 ; Mohanty et al, 2021 ; Oyeleye et al, 2021 ; Reyes-Becerril et al, 2021 ; Santos et al, 2021 ; Xiong et al, 2021 ), as food additive ( Milla et al, 2021 ; Okereke et al, 2021 ; Oyeleye et al, 2021 ) as well as for polluted water treatment in deprived rural settings ( Lea, 2010 ; Palada, 2019 ; Aboagye et al, 2021 ; Ueda Yamaguchi et al, 2021 ) has continued to gain momentum across different regions of the world without any attention to its potential toxicities. Here, the effects of the lipid-containing MOSE aqueous-methanol extracts on fertility and pregnancy outcome have been elaborately investigated in vivo using rodents for their potential effects on reproductive parameters, ovary, uterus, renal and hepatic histology.…”

Section: Introductionmentioning

confidence: 99%

Moringa oleifera Seed at the Interface of Food and Medicine: Effect of Extracts on Some Reproductive Parameters, Hepatic and Renal Histology

et al. 2022

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The lipid-rich Seed of Moringa oleifera has been promoted as an effective water clarifier. Aside its vital nutritional application as an emerging food additive, the seed has continued to gain a wider acceptance in various global ethnomedicines for managing several communicable and lifestyle diseases, howbeit, its potential toxic effect, particularly on fertility and pregnancy outcomes has remained uninvestigated; the effect of Moringa oleifera seed (MOSE) aqueous-methanol extracts on fertility and pregnancy outcome, was investigated in vivo using female Wistar rats that were divided into 50, 100, 300 and 500 mg per kilogram body weight. Group six was given Moringa oleifera seed treated water ad-libitum (ad-libitum group). Organs harvested for histological assessment included ovary, uterus, liver and kidney. In addition to HPLC fingerprint and a preliminary peptide detection, we determined the physico-chemical characteristics and mineral content of MOSE using standard methods. Data were analyzed with significance at p ≤ 0.05. There was no significant difference in the estrus cycle, mating index, gestation survival index, gestation index, fertility index and sex ratio among all groups. Gestation length was reduced in some groups. While the male pup birth weight was comparable among the different groups, female pups birth weights were significantly reduced in 50 and 100 mg groups. Anogenital distance indices of female pups in ad libitum group were significantly increased. Pathologies were observed in liver and kidneys of dams while kidneys of pups presented a dose dependent reduction in the number of glomeruli. There were no observed pathological changes in the ovary and uterus. This study showed for the first time in rodents, that the lipid-rich MOSE is unsafe to the kidney of rodents while the lipid-free MOSE appears to be safe at doses up to 300 mg/kg body weight. Findings from this study suggested that the female pups were masculinized. In conclusion, the lipid-rich seed extracts of MOSE appear to be unsafe during pregnancy, induce hepatic and renal toxicity while the lipid-free MOSE excludes inherent toxicity as the hydrophobic part has been linked to toxicity as observed in this study due to the developmental programming effect on female offspring in rodents.

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Anti-Candida activity of the water-soluble lectin from Moringa oleifera seeds (WSMoL)

Cited by 23 publications

References 23 publications

ATIVIDADES BIOTECNOLÓGICAS DAS LECTINAS DE Bauhinia forficata: PLANTA COM EFEITO HIPLOGLICÊMICO

ATIVIDADES BIOTECNOLÓGICAS DAS LECTINAS DE Bauhinia forficata: PLANTA COM EFEITO HIPLOGLICÊMICO

Fitoterapia Aplicada Ao Controle De Obesidade: Uma Breve Revisão

Moringa oleifera Seed at the Interface of Food and Medicine: Effect of Extracts on Some Reproductive Parameters, Hepatic and Renal Histology

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