Anti-CD22-conjugated CdTe QDs co-loaded with doxorubicin and gambogic acid: a novel platform for lymphoma treatment

Abstract

DOX/GA–CdTe–CD22 can precisely target lymphoma and deliver DOX and GA to lymphoma cells to improve their therapeutic effects.

Doxorubicin-Loaded PEG-CdTe Quantum Dots as a Smart Drug Delivery System for Extramedullary Multiple Myeloma Treatment

“…Furthermore, no significant difference was found between the PEG-CdTe group and the control group, which confirmed PEG-CdTe had no therapeutic activity in vitro. What should be noted is that our results indicate the high safety and low cytotoxicity of PEG-CdTe at low concentration, which is consistent with other studies [ 12 , 27 ]. However, the apoptosis rate of PMIR 8226 cells evaluated by FCM in the PEG-CdTe-DOX group is obviously higher than the DOX group ( P < 0.01).…”

“…Our study revealed that PEG-CdTe nanoparticles could load DOX with high DL and EE (Fig. 2e ), which are consistent with other studies [ 12 , 13 ]. Moreover, the PEG-CdTe nanoparticles in diameter of 8.2 nm (< 10 nm) could be quickly metabolized by the urinary system [ 23 ], and PEG-CdTe-DOX nanoparticles in size of 78.31 nm (< 200 nm) prolonged the blood circulation time and reduced or even avoided plasma opsonization and absorption in the reticuloendothelial system [ 23 ].…”

“…Caspase-3 may not only promote apoptosis, while surviving is the strongest inhibitor of apoptosis, but also promotes cell proliferation, which can directly in activate caspase-3 and caspase-7, thereby blocking the apoptosis [ 31 , 32 ]. Caspase-3, an executioner in the caspase family, can also cleave and inactivate poly-adp-ribose polymerase when initiated [ 12 ]. In the present study, the expressions of related apoptotic proteins were detected to explore the molecular mechanism how PEG-CdTe-DOX enhanced antitumor activity.…”

“…DOX-loaded platelets can enhance the therapeutic effectiveness for lymphoma [ 11 ]. Nanoparticles (e.g., cadmium telluride quantum dots or CdTe QDs) can prolong circulation time and drug release in a pH-controlled manner, improve efficacy, and reduce drug toxicity [ 12 – 16 ]. Polyethylene glycol (PEG), featured by hydrophilicity, high biocompatibility, safety, non-toxicity, and low immunogenicity, can be conjugated with CdTe QDs (PEG-CdTe QDs) to induce an “immune-neglected” effect, reducing or even avoiding plasma opsonization and absorption by the reticuloendothelial system [ 14 ].…”

<p>Daunorubicin-Loaded CdTe QDs Conjugated with Anti-CD123 mAbs: A Novel Delivery System for Myelodysplastic Syndromes Treatment</p>

“…9 In recent years, many scholars have used CdTe QDs as a drug delivery vehicle to construct drug-loaded nanosystem such as DNR-GA-Cys-CdTe NPs and DOX/GA-CdTe-CD22, which can deliver drugs to tumor cells, thereby improving the antitumor activity of the drug and attenuating its toxicity against normal tissues. 10,11 CD123, an interleukin-3 receptor (IL-3R) alpha chain, is regarded as a marker of leukemia stem cells (LSCs) and is correlated with tumor load and poor prognosis. 12 Many reports have shown that CD123 is highly expressed on cells of high-grade MDS patients, similar to those in AML and it is low in normal hematopoietic stem cells and low-grade MDS.…”