Anti-CD47 antibody administration via cisterna magna in proper dosage can reduce perihematomal cell death following intracerebral hemorrhage in rats

Song, Yan; Wang, Huaqing; Li, Feng; Huang, Qibing; Zhang, Ze-Li

doi:10.1016/j.brainresbull.2021.07.003

Cited by 4 publications

(3 citation statements)

References 31 publications

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“…Expression of CD47 on myelin debris may hinder its clearance and contribute to Wallerian degeneration 58 . In hemorrhagic stroke, downregulation of CD47 expression boosts the number of phagocytic microglia/macrophages, enhances erythrocyte phagocytosis, and fosters the resolution of hematomas and other blood components 59–63 . However, activation of CD47 may influence brain injury and recovery through other mechanisms.…”

Section: Microglia/macrophage Phagocytosis Signaling In Response To C...mentioning

confidence: 99%

“… 58 In hemorrhagic stroke, downregulation of CD47 expression boosts the number of phagocytic microglia/macrophages, enhances erythrocyte phagocytosis, and fosters the resolution of hematomas and other blood components. 59 , 60 , 61 , 62 , 63 However, activation of CD47 may influence brain injury and recovery through other mechanisms. In ischemic stroke, the CD47 signaling pathway may contribute to neutrophil extravasation into the brain parenchyma and amplify neuroinflammation.…”

Section: Microglia/macrophage Phagocytosis Signaling In Response To ...mentioning

confidence: 99%

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Phagocytic microglia and macrophages in brain injury and repair

Wang

Stetler

et al. 2022

CNS Neurosci Ther

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Section: Microglia/macrophage Phagocytosis Signaling In Response To C...mentioning

confidence: 99%

Section: Microglia/macrophage Phagocytosis Signaling In Response To ...mentioning

confidence: 99%

Phagocytic microglia and macrophages in brain injury and repair

Wang

Stetler

et al. 2022

CNS Neurosci Ther

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“…Except for reducing oxidative damage, it effectively reinforces the function of M2 microglia (Hu et al, 2019 ). RBC CD47 is a signal that stops itself from being swallowed by microglia (Song et al, 2021 ; Ye et al, 2021 ). Deferoxamine inhibited CD47 expression on RBCs and accelerated hematoma absorption conspicuously in pig models (Cao et al, 2016 ; Hu et al, 2019 ).…”

Section: Clinical Researches Targeting Microgliamentioning

confidence: 99%

Microglia Phenotype and Intracerebral Hemorrhage: A Balance of Yin and Yang

Fang

You

et al. 2021

Front. Cell. Neurosci.

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Intracerebral hemorrhage (ICH) features extremely high rates of morbidity and mortality, with no specific and effective therapy. And local inflammation caused by the over-activated immune cells seriously damages the recovery of neurological function after ICH. Fortunately, immune intervention to microglia has provided new methods and ideas for ICH treatment. Microglia, as the resident immune cells in the brain, play vital roles in both tissue damage and repair processes after ICH. The perihematomal activated microglia not only arouse acute inflammatory responses, oxidative stress, excitotoxicity, and cytotoxicity to cause neuron death, but also show another phenotype that inhibit inflammation, clear hematoma and promote tissue regeneration. The proportion of microglia phenotypes determines the progression of brain tissue damage or repair after ICH. Therefore, microglia may be a promising and imperative therapeutic target for ICH. In this review, we discuss the dual functions of microglia in the brain after an ICH from immunological perspective, elaborate on the activation mechanism of perihematomal microglia, and summarize related therapeutic drugs researches.

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