Anti-cholinergic effect of<i>Zataria multiflora</i>Boiss on guinea pig tracheal chains

Boskabady, Mohammad Hossein; Jafari, Zahra; Pouraboli, Iran; Babazade, Beheshteh; Rahbardar, Mahboobeh Ghasemzadeh

doi:10.1080/14786419.2011.565007

Cited by 30 publications

(26 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…(Z. multiflora) and its constituent, carvacrol, on muscarinic receptors in tracheal smooth muscles was also investigated by evaluating their effect on the concentration-response curve for methacholine. The parallel rightward shifts in the methacholine concentration-response curve and the maximum response to methacholine achieved in the presence of test solutions indicate the competitive effect of Z. multiflora extract and carvacrol on muscarinic receptors (Boskabady et al, 2012a).…”

Section: Inhibitory Effect On Muscarinic Receptorsmentioning

confidence: 98%

See 1 more Smart Citation

A review of the relaxant effect of various medicinal plants on tracheal smooth muscle, their possible mechanism(s) and potency

Shakeri

Boskabady

2015

Journal of Ethnopharmacology

Self Cite

View full text Add to dashboard Cite

Section: Inhibitory Effect On Muscarinic Receptorsmentioning

confidence: 98%

“…In one study, the hydro-alcoholic extract of Z. multiflora was shown to have potent relaxant effects on the tracheal smooth muscles of guinea pigs (Boskabady et al, 2012a). The relaxant effects of various medicinal plants, which were evaluated using various methods, are summarized in Table 2.…”

Section: Zataria Multifloramentioning

confidence: 99%

A review of the relaxant effect of various medicinal plants on tracheal smooth muscle, their possible mechanism(s) and potency

Shakeri

Boskabady

2015

Journal of Ethnopharmacology

Self Cite

View full text Add to dashboard Cite

“…In experiments with parallel shift in methacholine-response curve, the concentration-ratio minus one (CR-1) as an index of the competitive antagonism effect was calculated by Eqn. 1 [24] .…”

Section: Protocolsmentioning

confidence: 99%

“…0210) and measured by using a software by a computer (Acer Model No. G781) recording [24] . The study was approved by the University's Ethics Committee.…”

Section: Animals and Tissue Preparationsmentioning

confidence: 99%

Portulaca olerace Affects Muscarinic Receptors of Guinea Pig Tracheal Smooth Muscle

Hashemzehi¹,

Khazdair²

2016

pharmaceutical-sciences

View full text Add to dashboard Cite

Hashemzehi, et al.: Effect of Portulaca oleracea on Musacrinic ReceptorsThe relaxant effect of Portulaca oleracea L. on tracheal smooth muscles has been shown. The effect of the plant on muscarinic receptors of tracheal smooth muscles as one possible mechanism responsible for its relaxant effect was examined. Concentration response curves to methacholine were performed in the presence of three concentrations of aqueous-ethanol extract from aerial part of the plant (0.25, 0.50 and 1.00 mg/ml), 10 nM atropine, and saline. The values of EC 50 (effective concentration causing 50% of maximum response) and CR-1 ((EC 50 of test solutions/EC 50 of saline)-1) were measured. The study was done using three designs as non-incubated (group 1), incubated tissues with propranolol and chlorpheniramine (group 2) and incubated tissues with propranolol (group 3). Concentration-response curves to methacholine were shifted to the right and EC50 methacholine were significantly higher in the presence of atropine, medium and highest extract concentrations in all groups and its low concentration in group 3 compared to saline. In addition, EC 50 methacholine in the presence of high extract concentration (27.00±2.12) in group 2 was greater than its low (10.33±1.54) and medium (16.83±2.52) concentrations (p<0.05). The values of the CR-1 obtained in the presence of all extract concentrations in all groups were lower than that of atropine (P<0.05 to P<0.001). An inhibitory effect for the extract of P. oleracea on muscarinic receptors of tracheal smooth muscles was shown and a histamine (H 1 ) receptor blockade was also suggested.Key words: Portulaca oleracea, muscarinic receptor, tracheal smooth muscle, inhibitory effect, aqueousethanol extract Portulaca oleracea L. is an annual succulent which may reach 15.75 inches in height with alternate leaves clustered at stem joints; the yellow flower plant grows in different areas of the world including north and northwest of Iran [1] . Main active constituents of P. oleracea are omega-3 fatty acid, α-linolenic acid and eicosa-pentaenoic acid. This plant also contains vitamins (mainly vitamins A, C and some vitamin B) [2,3] . The plant also contains organic acids such as citric, maleic, cyanuric, caffeic acid as well as flavonoids, coumarins, and glycosides [4] .P. oleracea has several therapeutic effects including diuretic, antiascorbic, antipyretic, antiinflammatory [5][6][7] . The plant is also used for treatment of type-2 diabetes mellitus patients [8] . Different pharmacologic effects of this plant are antiinflammatory, analgesic [6] , antioxidant [9][10][11] , potassium channel opener and blood pressure modifier [12] , as well as neuropharmacological [13,14] , wound healing [15] , antibacterial [16] and antipyretic effects [17] . The relaxant effect of this plant was studied on skeletal muscles [18] and smooth muscle of small intestine [19] . Our previous studies also showed relaxant effect of the plant on tracheal smooth muscle [20] and the possible mechanism of this effect for this plant [21]...

show abstract

“…Carum copticum (1) and Crocus sativus (2) showed nonparallel rightward shift in methacholine concentration response curves, and maximum effect to methacholine in the presence of the plant was not achieved, which caused non-competitive antagonistic effect of this plant on muscarinic receptors. However, Nigella sativa (3), Zataria multiflora (4) and Achillea millefolium (5) showed competitive antagonistic effects on muscarinic receptors by parallel rightward shift in methacholine concentration curves, and achievement of maximum repose to methacholine in the presence of the extracts of the above mentioned plants.…”

Section: Introductionmentioning

confidence: 99%

The Inhibitory Effects of Ferula assafoetida on Muscarinic Receptors of Guinea-Pig Tracheal Smooth Muscle

Khazdair

Boskabady

Kiyanmehr

et al. 2015

Jundishapur J Nat Pharm Prod

Self Cite

View full text Add to dashboard Cite

Background: In traditional medicine, asafoetida obtained from the roots of different Ferula assafoetida (F. asafoetida) is used for various therapeutic purposes such as whooping cough, pneumonia and bronchitis in children, as well as asthma. Objectives: In this study, the effect of asafoetida on muscarinic receptors of tracheal smooth muscle, as one possible mechanism responsible for the relaxant effect seen for the plant, was evaluated. Materials and Methods:The effects of three cumulative concentrations of aqueous extract of F. asafoetida (2.5, 5 and 10 mg/mL), 10 nM atropine, and saline on muscarinic receptors were tested in tracheal smooth muscle samples by performing cumulative concentration response curve to methacholine (a muscarinic receptor agonist) and assessing the shift in concentration response curves due to different concentrations of the extract and atropine. Results: The EC 50 obtained in the presence of higher concentration of the extract muscle was significantly higher compared to saline (P < 0.01). The maximum responses to methacholine in the presence of higher concentration of the extract (10 mg/mL) was significantly lower than that of saline (P < 0.05). The values of CR-1, obtained in the presence of all concentrations of the extract, were significantly lower compared to atropine in the experimental group (P < 0.01 to P < 0.001). Conclusions: These results showed an inhibitory effect for the extract of asafetida on muscarinic receptors of tracheal smooth muscle.

show abstract

Anti-cholinergic effect ofZataria multifloraBoiss on guinea pig tracheal chains

Cited by 30 publications

References 11 publications

A review of the relaxant effect of various medicinal plants on tracheal smooth muscle, their possible mechanism(s) and potency

A review of the relaxant effect of various medicinal plants on tracheal smooth muscle, their possible mechanism(s) and potency

Portulaca olerace Affects Muscarinic Receptors of Guinea Pig Tracheal Smooth Muscle

The Inhibitory Effects of Ferula assafoetida on Muscarinic Receptors of Guinea-Pig Tracheal Smooth Muscle

Contact Info

Product

Resources

About