Anti-coccidial Activity of Moringa Oleifera Plant

Abstract

Abstract:Moringa Oleifera leaves were screened for its toxicological effect and some pharmacological activities in broiler chicken. Toxicological effect was studied using upgrading oral doses of 75% ethanolic extract in different groups of mice with monitoring the toxicological symptoms and mortality rate. The anti-coccidal activity of Moringa Oleifera powdered leaves for prevention and its 75% ethanolic extract for treatment of coccidiosis were studied in broilers. The obtained result proved that there were no toxicological symptoms or mortalities obtained till oral administration of 6000 mg/kg b. wt. Inclusion of Moringa olifera powder (0.5 and 1%) to broiler's feed were very efficacious and equal to diclazuril (1ppm) in preventing symptoms of coccidiosis associated with experimental infection with mixed Eimeria species. The anti-coccidal activity of Moringa Oleifera powdered leaves and its 75% ethanolic extract were studied on one-day old chicks. The experimental infected chicks with mixed Eimeria species induced severe coccidiosis in non medicated chicks and led to high mortality reached to (26.76%). Addition of 200 and 400ppm of Moringa Oleifera ethanolic extract induced marked curative effect of cocci diosis manifested by reduced mortality percent and improved PM lesion to be 13.3 and 10% respectively compared to 13.3% for group treated with the reference drug (25ppm) toltrazuril.

Potential Applications of Moringa oleifera in Poultry Health and Production as Alternative to Antibiotics: A Review

“…Herbal remedies may be an option for treating coccidiosis in chickens, with the drumstick tree ( M. oleifera ) showing promise. Banna et al [ 117 ] found that adding M. oleifera powder (0.5 and 1%) to broiler feed was extremely effective in reducing coccidiosis symptoms associated with experimental infection with mixed Eimeria species and was comparable to diclazuril (1 ppm). According to Banna et al [ 117 ], M. oleifera has a strong anticoccidial activity and may be a viable option for the prevention of avian coccidiosis in chicken production.…”

“…Banna et al [ 117 ] found that adding M. oleifera powder (0.5 and 1%) to broiler feed was extremely effective in reducing coccidiosis symptoms associated with experimental infection with mixed Eimeria species and was comparable to diclazuril (1 ppm). According to Banna et al [ 117 ], M. oleifera has a strong anticoccidial activity and may be a viable option for the prevention of avian coccidiosis in chicken production. In addition to its growth-promoting effect, safety, and antibacterial action, it may be used as a preventative and curative agent for coccidia.…”

Characterization and bioactivities of M. arvensis, V. officinalis and P. glabrum: In-silico modeling of V. officinalis as a potential drug source

“…The methanolic crude extracts of V. officinalis and P. glabrum exhibit antioxidant activity ( Casanova et al, 2008 , Raja and Ramya, 2017 ), which supports the reduction in oocysts shedding in the effective groups. The natural products usually don’t harm a living being with some exceptions, as El Banna, (2016) said that Moringa olifera doesn’t lead to any toxic effect. Similarly, the chicks under trial don’t bear any negative pressure of V. officinalis and P. glabrum methanolic extracts except for the higher concentration (15 mg/ml) of V. officinalis , which yields better FCR but negatively affected the blood and serum profile severely, the exact reason of which is unclear but may be possible due to overdose.…”

In vitro Sporulation, Oocysticidal Sporulation Inhibition of Eimeria papillate and Cytotoxic Efficacy of Methanolic Extract of Thymus daenensis Leaves

“…Chemoprophylaxis, is one of the traditional strategies to control parasitic diseases, but it is expensive. Furthermore, long-term usage of anticoccidial medications resulted in drug resistance (El Banna et al, 2016). There are also concerns regarding food safety and public health as a result of medicine residues in animal products, which motivates researchers to seek safer alternatives (Wunderlich et al, 2014).…”