Anti‐cyclic citrullinated peptide: diagnostic and prognostic values in juvenile idiopathic arthritis and rheumatoid arthritis in a Chinese population

Kwok, Janette; Hui, K H; Lee, T L; Wong, Wing Sze; Lau, Y. L.; Wong, Raymond Woon Sing; Kim, D L; Jones, B.

doi:10.1080/03009740510026634

Cited by 65 publications

(51 citation statements)

References 30 publications

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“…Our findings showed that the prevalence rates of all ACPAs in the whole population of JIA patients were less than 30% and much lower than those of adult RA patients, which agrees with the results reported in previous studies on anti-CCP (Avcin et al, 2002;Bongi et al, 2004;Kasapçopur et al, 2004;Kwok et al, 2005;Gilliam et al, 2011;Tebo et al, 2012). Therefore, we confirmed that ACPAs cannot serve as screening biomarkers for the general JIA population due to their low sensitivity.…”

Section: Discussionsupporting

confidence: 81%

Diagnostic performance of anti-citrullinated protein/peptide antibodies in juvenile idiopathic arthritis

et al. 2016

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ABSTRACT. The prevalence rates of anti-citrullinated protein/peptide antibodies (ACPAs) were investigated in a cohort of juvenile idiopathic arthritis (JIA) patients, and their diagnostic performances were compared. ACPAs, including anti-cyclic citrullinated peptide IgG (anti-CCP), anti-CCP IgG/IgA (anti-CCP3.1), citrullinated recombinant rat filaggrin antibodies (CPA), anti-mutated citrullinated vimentin (anti-MCV), and antibodies to citrullinated human IgG-derived peptides (RA/CP), were measured in the sera from 81 JIA patients. Serum samples from 55 children with other joint diseases or viral infections and 49 healthy donors were tested as controls. Of the 81 JIA patients, 7 (8.6%), 8 (9.9%), 17 (21.0%), 23 (28.4%), and 18 (22.2%) were found to be positive for anti-CCP, anti-CCP3.1, CPA, anti-MCV, and RA/CP, respectively, with specificities of 98.1, 95.1, 93.3, 84.6, and 86.5%. Analysis by subtype revealed that 7/7 (100%) of RF-positive polyarticular JIA patients tested positive at high serum levels for anti- MCV or RA/CP, and 5/7 (71.4%) were positive for anti-CCP, anti-CCP3.1, or CPA (P < 0.001, compared with controls). Eighteen of 81 JIA patients demonstrated joint erosions on radiographs and erosive arthritis occurred more often in ACPAs positive patients (P < 0.01). Our findings indicate that although ACPAs are not satisfactory screening biomarkers for JIA due to low sensitivity, ACPA measurement can aid in diagnosing RF-positive polyarticular JIA and identifying JIA patients with severe bone involvement. The diagnostic performance of each ACPA in JIA is different, and the careful selection of assays is necessary.

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Section: Discussionsupporting

confidence: 81%

Diagnostic performance of anti-citrullinated protein/peptide antibodies in juvenile idiopathic arthritis

et al. 2016

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“…Numerous studies have shown that IgM RF-positive polyarthritis patients have a higher prevalence of anti-CCP antibodies [36][37][38][39][40][41][42][43][44]45 We have also shown that the measurement of IgA, IgM, and IgG anti-CCP antibody isotypes early in the course of JIA may be beneficial to distinguish aggressive disease and possibly initiate more aggressive treatment earlier in those patients [48•]. These patients have been shown to have higher immune complex levels by the anti-Fc III method of detection and are noted to have increased disease activity [49•].…”

Section: Discussionmentioning

confidence: 99%

“…Kwok et al [41] evaluated anti-CCP antibodies using second generation peptides in a Chinese cohort of JIA patients and found 6 of 59 (10%) with elevated anti-CCP antibodies. Similar to previous findings [36][37][38][39][40], 80% (4/5) of their cohort with elevated anti-CCP antibodies had IgM RF-positive polyarthritis.…”

Section: Anticyclic Citrullinated Peptide Antibodiesmentioning

confidence: 98%

Rheumatoid factors and anticyclic citrullinated peptide antibodies in pediatric rheumatology

Syed

Gilliam²,

Moore

2008

Curr Rheumatol Rep

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Juvenile idiopathic arthritis (JIA) is a heterogenous childhood disease without reliable biomarkers for monitoring disease progression. Immunoglobulin (Ig) M rheumatoid factor (RF) is used to define a subset of JIA patients, but its significance in JIA is dependent on the method of measurement. In addition to IgM RF, IgA RF has been implicated in determining disease severity in JIA, including functional disability and joint damage. Anticyclic citrullinated peptide (anti-CCP) antibodies have been a valuable diagnostic tool in rheumatoid arthritis, with varied results in their significance in JIA patients. Recent studies have demonstrated the possible usefulness of isotypes of anti-CCP antibodies in monitoring JIA patients to determine disease outcome. Overall, RF isotypes and anti-CCP isotypic antibodies have demonstrated increasing importance in the evaluation of JIA patients to determine which patients may have more aggressive or severe disease and to aid in possible treatment plans to prevent joint damage and disability.

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“…Anti-CCP is present in the serum of a portion of RA patients and has been identified in the serum of patients at all stages of RA: preclinical, early, and established (Taylor et al 2011). In clinical research studies, anti-CCP antibodies were found in 55-69% of patients with RA (Kwok et al 2005) and 65% of RA patients with late-onset RA (Lopez-Hoyos et al 2004). Recent clinical trials suggest that anti-CCP is highly accurate in selectively identifying RA patients (Nikolaisen et al 2007;Quinn et al 2006) and is of particular diagnostic use in patients who are negative for RF (Quinn et al 2006) and an indicator of prognosis (Bas 2005).…”

Section: Foot Involvement In Rheumatoid Arthritismentioning

confidence: 98%

Rheumatic Diseases

Williams¹,

Corkill²

2015

Management of Chronic Conditions in the Foot and Lower Leg

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Anti‐cyclic citrullinated peptide: diagnostic and prognostic values in juvenile idiopathic arthritis and rheumatoid arthritis in a Chinese population

Cited by 65 publications

References 30 publications

Diagnostic performance of anti-citrullinated protein/peptide antibodies in juvenile idiopathic arthritis

Diagnostic performance of anti-citrullinated protein/peptide antibodies in juvenile idiopathic arthritis

Rheumatoid factors and anticyclic citrullinated peptide antibodies in pediatric rheumatology

Rheumatic Diseases

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