Anti-diabetic activity of alcoholic extract of Aerva lanata (L.) Juss. ex Schultes in rats

Vetrichelvan, T.; Jegadeesan, M.

doi:10.1016/s0378-8741(01)00412-3

Cited by 59 publications

(40 citation statements)

References 13 publications

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“…The roots are reported to contain various phytoecdysteroids, three feruloylamines, four flavonoid glycosides, b-sitosterol, palmitic acid, a-and b-amyrin, tannins, alkaloids such as canthin-6-one derivatives, b-carboline-1-propionic acid, daucosterol, syringic acid, vanillic acid, narcissin, feruroyltyramine, feruloylhomovanillylamine and aervitrine (Aiyer et al, 1973;Baltaev et al, 1992;Chandra & Sastry, 1990;Yamunadevi et al, 2011a,b,c;Yuldashev et al, 2002;Zapesochnaya et al, 1990Zapesochnaya et al, , 1991Zapesochnaya et al, , 1992a. Biologically various extracts of different parts of plants are reported to have antimicrobial (Chowdhury et al, 2002), diuretic (Majmudar et al, 1999), anti-inflammatory (Vetrichelvan et al, 2000), hepatoprotective (Nevin & Vijayammal, 2005a), immunomodulatory effect (Nevin & Vijayammal, 2005b), nephroprotective (Soundararajan et al, 2006), antihyperglycaemic (Vetrichelvan & Jegadeesan, 2002) and hypolipidemic activity (Rajesh et al, 2011). Aerva lanata (AL) is used as main ingredients for Jathyadi Gritham (Asoka Pharmaceuticals, Kannur, India) for the treatment of ulcer and D-BEAT 99 capsule (Pharmacon Remedies Pvt.…”

Section: Introductionmentioning

confidence: 99%

Antidiabetic activity of alkaloids ofAerva lanataroots on streptozotocin-nicotinamide induced type-II diabetes in rats

Agrawal¹,

Sethiya²,

Mishra³

2013

Pharmaceutical Biology

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Context: The roots of Aerva lanata Linn. (Amaranthaceae) (AL) are employed traditionally as an antihyperglycaemic in the Ayurvedic system of medicine. Objective: The present investigation is focus for identification and isolation of the bioactive compound from methanol roots extract of AL against streptozocin-nicotinamide induced elevated serum glucose level in rats. Materials and methods: The methanol extract of the roots was fractionated using different solvents. The partially purified alkaloid basified toluene fraction (PPABTF) showed the presence of alkaloids. The fraction (10 and 20 mg/kg) was tested for oral glucose tolerance test (OGTT) and in non-insulin-dependent diabetes mellitus (NIDDM)-induced elevated serum glucose level in rats. The fraction was also subjected to high performance thin layer chromatography (HPTLC) for the determination of content of individual alkaloids. Results: Single oral administration of PPABTF (10 and 20 mg/kg) after 20 h caused a significant (p50.01) reduction in the serum glucose level (mg/dl). On other hand, PPABTF normalised plasma glucose levels after 2 weeks of repeated oral administration in diabetic rats (p50.01). HPTLC analysis on PPABTF showed the presence of three known alkaloids. The fraction was further subjected to column chromatography and the compounds identified by ultraviolet, infrared, mass spectroscopy and nuclear magnetic resonance, as canthin-6-one derivatives. Conclusion and discussion: The PPABTF in the dose of 20 mg/kg showed significant effects on streptozotocin-nicotinamide induced type-II NIDDM in rats. The activity may be due to the presence of alkaloids like canthin-6-one derivatives.

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Section: Introductionmentioning

confidence: 99%

Antidiabetic activity of alkaloids ofAerva lanataroots on streptozotocin-nicotinamide induced type-II diabetes in rats

Agrawal¹,

Sethiya²,

Mishra³

2013

Pharmaceutical Biology

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“…In general, polyphenols are contained in the seeds, fruits, leaves and barks of medicinal plants [28] and protect plants from other external invaders [26]. Therefore, the antidiabetic effects of medical plants can be triggered by various flavonoids, glycosides and terpenoids [5,7,31]. The amount of polyphenol may vary depending on the extraction method as the more ethanol we use for extraction, the less hydrophilic polyphenol compounds we can extract.…”

Section: Discussionmentioning

confidence: 99%

“…In general, traditional medical plants contain a wide range of polyphenol compounds such as flavonoids, glycosides and terpenoids, which are effective in treating DM [5,7,31]. However, the amount and efficacy of polyphenol compounds may differ depending on extraction methods.…”

mentioning

confidence: 99%

Antidiabetic Effects of Leaves Extracts of Psidium guajava L. and Lagerstroemia speciosa L. in STZ-induced Rats

2009

Journal of Life Science

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Guava (Psidium guajava L.) and banaba (Lagerstroemia speciosa L.) are well known as medicinal plants for their antidiabetic effects. These contain a great deal of polyphenol compound and work on the treatment of diabetes mellitus effectively. In this study, the extracts of guava and banaba are consumed by streptozotocin (STZ) induced diabetic rats to compare the antidiabetic effects. According to the comparison result, the glucose level of those STZ-induced diabetic rats has decreased by 19-32%, total cholesterol by 24-46%, triglyceride by 22-67% and free fatty acid by 49-71% approximately compared to the diabetic rats, while the generation of insulin and the recovery of beta cells have increased. However, the result showed that the antidiabetic effect of guava extracts was higher than that of banaba extracts. This is because the hydrophilic polyphenol compounds contained in banaba leaves were not extracted during the ethanol extraction process, and the antidiabetic activity of the extracted corosolic acid was low to surprise.Key words : Guava (Psidium guajava), banaba (Lagerstroemia speciosa), polyphenol, anti-diabetic effects *Corresponding author *Tel：+82-51-510-2262, Fax：+82-51-510-3736 *E-mail : wcchoi@pusan.ac.kr Introduction Diabetes mellitus (DM) causes the chronical metabolism disorder which makes approx. 4% of the world population suffer and this figure is expected to increase to 5.4% [16]. Hyperglycemia triggered by DM is usually caused due to the decrease in insulin secretion, decrease in glucose utilization of tissue and increase in the generation of glucose. Hyperglycemia's symptoms include obsessive thirst, glucosuria, polyuria, lipemia and hunger, and if left without treatment, this can result in patient's death due to critical ketoacidosis [27].For ages, many countries have applied traditional medical plants to treat hyperglycemia and diabetes mellitus [1,6,13,26], and more than 400 plants have been reported with their glucose reduction effects [2]. Recently the interest on medical plants is getting high as oral agents used to treat DM cause various side effects [4,15] while taking traditional medical plants in a natural form of extracts show treatment effect as good as that of therapeutic agents without side effects.In general, traditional medical plants contain a wide range of polyphenol compounds such as flavonoids, glycosides and terpenoids, which are effective in treating DM [5,7,31]. However, the amount and efficacy of polyphenol compounds may differ depending on extraction methods. If the ethanol extraction method is used, polyphenol compounds can hardly extracted.Psidium guajava L. known as guava is a representative medical plant that has antidiabetic effects and the interest on guava has been increased recently. Guava leaves contain a variety of polyphenol compounds such as polyphenol [25], terpenoids [3,23], flavonoids [20] and tannins [29]. And it was reported that guava leaves have antidiabetic effects direct and indirect through controlling glucose increase [22] and carbohydrate hyd...

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“…The whole plant of A. lanata was used for the treatment of hepatitis, anticalculus, diuretic, demulcent, anthelmintic and antidiarrheal (Shoba and Mythili, 2017). Some of the phytochemicals from A. lanata (aervitrin, aervolanine, aervoside, amyrin, betulin, campesterol, canthin-6-one, 10-hydroxycanthin-6-one, chrysin, daucosterol, hentriacontane, narcissin, β-sitosterol, and syringic acid) were isolated and reported with biological activities (Vetrichelvan and Jegadeesan, 2002).…”

Section: Isolation Of Isosativenetriol From Endophytic Fungus Cochliomentioning

confidence: 99%

Isolation of isosativenetriol from endophytic fungus Cochliobolus spp. of Aerva lanata

Shoba

Sasikumar

Sathiavelu

2018

Bangladesh J Pharmacol

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Anti-diabetic activity of alcoholic extract of Aerva lanata (L.) Juss. ex Schultes in rats

Cited by 59 publications

References 13 publications

Antidiabetic activity of alkaloids ofAerva lanataroots on streptozotocin-nicotinamide induced type-II diabetes in rats

Antidiabetic activity of alkaloids ofAerva lanataroots on streptozotocin-nicotinamide induced type-II diabetes in rats

Antidiabetic Effects of Leaves Extracts of Psidium guajava L. and Lagerstroemia speciosa L. in STZ-induced Rats

Isolation of isosativenetriol from endophytic fungus Cochliobolus spp. of Aerva lanata

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