Anti-diabetic activity of Shilajatvadi Lauha, an Ayurvedic traditional herbo-mineral formulation

Singh, Thakur Rakesh; Gupta, L. N.; Kumar, Neeraj; Kumar, Vikas

doi:10.4103/2278-344x.173889

Cited by 3 publications

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“…[ 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 ] A few mineral/metal-based formulations including Shilajatu ( Asphaltum punjabianum ), Chandraprabha Vati , Shilajatvadi Lauha and some patented formulations were also being used by the diabetes patients. [ 38 39 40 41 ] The underlying anti-diabetic effects of these herbs may be because of one or the other types of the mechanism involving a direct effect on insulin secretion, activation of glycogenesis and hepatic glycolysis, adreno-mimeticism, pancreatic beta-cell potassium channel blocker activity, cAMP activation, and/or modulation of glucose absorption from the intestine, etc.…”

Section: Discussionmentioning

confidence: 99%

Patterns of concomitant use of Ayurveda and conventional anti-diabetic formulations - Experiences at a tertiary care Ayurveda hospital, India

Galib

Dang

Kumar

et al. 2020

AYU

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Background: Majority of the population relies on traditional medicines for many of their health related problems. Particularly individuals with chronic illness like diabetes mellitus (DM) are more likely to simultaneously use herbal medicines. Many of such users believe that traditional medicines are natural and therefore safe, but this is a dangerous over simplification. Some herbal medicines may be associated with adverse effects, which include interactions with prescribed drugs. Information on such concomitant use of anti-diabetic drugs along with Ayurveda medicines is limited in Indian scenario. Aims and objectives: To survey the patterns of concomitant use of Ayurveda and conventional anti-diabetic drugs by diabetic patients attending an out-patient department of a tertiary care teaching hospital in New Delhi, India through a validated questionnaire. Materials and methods: This is a questionnaire-based survey, carried out after the approval of the Institutional Ethics Committee, subsequently registered at CTRI. A questionnaire to assess the pattern of concomitant use was developed; content was validated and pre-tested by a pilot study in 40 patients, further refined and used in the survey. The data was analyzed to evaluate the patterns of concomitant use of Ayurvedic and conventional anti-diabetic drugs. Results: About 95.9% of diabetic patients were taking herbo-mineral formulations concomitantly with conventional anti-diabetic drugs. Although 45.3% of diabetics were using Ayurveda interventions under the supervision of qualified AYUSH physicians, remaining involved in procuring the drugs over the counter (OTC) or from the local vendors. In majority of these instances, the use of Ayurveda formulations was not communicated with their physicians. Conclusion: The observations reveal that a majority of the diabetics (95.9%) were taking one or the other form of herbal preparations along with their conventional anti-diabetic drugs and about 44% among them were using these concomitantly. Thus, generating awareness on good practices of drug use seems to be essential.

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Section: Discussionmentioning

confidence: 99%

Patterns of concomitant use of Ayurveda and conventional anti-diabetic formulations - Experiences at a tertiary care Ayurveda hospital, India

Galib

Dang

Kumar

et al. 2020

AYU

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A study on toxicity and anti-hyperglycemic effects of Abhrak Bhasma in rats

Gopinath

Shivashankar

2021

Journal of Ayurveda and Integrative Medicine

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Background Abhrak bhasma (AB) is widely used in the treatment of diabetes mellitus (DM); however, no scientific study is reported till date on its efficacy and safety to prove it's pharmacological effects. Streptozotocin (STZ) is a gulcosamine–nitrosourea complex produced by Streptomyces achromogenes , which particularly induces DNA strand breakage in pancreatic β-cells causing DM. The damage caused by STZ to pancreatic β-cells is coupled with insulin release in the initial stage, subsequently leading to hyperglycemia owing to insulin deficiency. Objective(s) In the present study, the safety and effectiveness of AB was evaluated by in vivo acute and sub-acute toxicity study and STZ-induced hyperglycemic activity in rats. Materials and methods Acute oral toxicity assessed as per OECD 425 guidelines by employing up-down procedure (UDP), sub-acute toxicity as per OECD-407 guidelines and anti-hyperglycemic activity using STZ method. The anti-hyperglycemic potential of AB in rats (40, 80, and 160 mg/kg body weight (b.w.)) was evaluated by determining the body weight, blood glucose, organ weight, lipid profile, and histo-morphological and histo-pathological investigations. Results The highest tolerated dose of AB was 2000 mg/kg b.w., and sub-acute toxicity of different AB doses showed no significant variation, when compared with the control. Interestingly, a noteworthy reduction in blood glucose, total cholesterol, and triglycerides levels were observed in AB-treated diabetic rats, along with a considerable increase in body weight, when compared with those noted in the disease control and normal control. Conclusion Effectiveness of AB as a potential safe and potent candidate for the treatment of diabetes was revealed as compared to the standard drug Metformin by STZ-induced method.

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Anti-diabetic potential of ‘Safūf-i-Dhayābītus’ as standalone and as an adjuvant with glibenclamide in streptozotocin-induced diabetic rats

et al. 2022

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Anti-diabetic activity of Shilajatvadi Lauha, an Ayurvedic traditional herbo-mineral formulation

Cited by 3 publications

References 0 publications

Patterns of concomitant use of Ayurveda and conventional anti-diabetic formulations - Experiences at a tertiary care Ayurveda hospital, India

Patterns of concomitant use of Ayurveda and conventional anti-diabetic formulations - Experiences at a tertiary care Ayurveda hospital, India

A study on toxicity and anti-hyperglycemic effects of Abhrak Bhasma in rats

Anti-diabetic potential of ‘Safūf-i-Dhayābītus’ as standalone and as an adjuvant with glibenclamide in streptozotocin-induced diabetic rats

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