Anti-diabetic and anti-lipidemic effects of chlorogenic acid are mediated by ampk activation

Ong, Khang Wei; Hsu, Annie; Tan, Benny Kwong Huat

doi:10.1016/j.bcp.2013.02.008

Cited by 336 publications

(242 citation statements)

References 37 publications

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“…This study was comparable with the previous study by Cho et al that revealed a significantly higher adiponectin level after 8 weeks administration of 0.02% CGA in diet compared to that of obese mice group [20]. Moreover, a study by Ong et al suggested that 2 weeks treatment of CGA from green coffee bean improved serum adiponectin level in Lepr db/db mice compared to that of diabetic mice [10]. To the extent of our knowledge, this study was the first study that proved the benefit of CGE in MS rat.…”

Section: Lukitasari Et Alsupporting

confidence: 90%

“…Chlorogenic acid (CGA) as the most abundant phenolic acid found in green coffee bean may exert antidiabetic, antihyperlipidemia, and antiobesity [7][8][9] effects. Animal experiments suggested that green coffee bean extract (GCE) rich CGA have beneficial effects on glucose and lipid metabolism disorders in high-fat diet (HFD)-induced mice and rats and can also improve insulin sensitivity in genetically predisposed animals [10]. The effect of GCE could be increased by roasting process.…”

Section: Introductionmentioning

confidence: 99%

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Light-Roasted Green Coffee Extract Improved Adiponectin, Insulin Resistance, and Metabolic Profile of Metabolic Syndrome Rat Model

Lukitasari

Nugroho

Rohman

et al. 2017

Asian J Pharm Clin Res

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Objective: The objective of this study is to investigate the effect of light-roasted green coffee bean extract (GCE) administration for 7 weeks on the improvement of metabolic profile, adiponectin level, homeostatic model assessment insulin resistance (HOMA-IR) index in metabolic syndrome (MS) rat model. Methods:Adult male Sprague-Dawley rats were induced by a combination of high sucrose and high-fat diet for 8 weeks and streptozotocin injection in the 2 nd week. The MS was confirmed by NCEP-ATP III criteria. They were divided into six weight-matched groups (n=5), normal control, MS, metformin and simvastatin-treated group (DMS), 100 and 200/body weight (bw) GCE (GCE 100 and GCE 200, respectively). The extracts were given through oral gavage daily for 7 weeks. The effect of GCE on body weight, serum glucose, triglyceride, (TG) and high-density lipoprotein (HDL) level was analyzed by colorimetric method. HOMA-IR index and adiponectin were analyzed by enzyme-linked immunosorbent assay methods.Result: Fasting blood glucose, TG, and systolic blood pressure decreased significantly (p<0.05) in both GCE groups. Moreover, after 7 weeks, those parameters were significantly lower (p<0.05) compared to that of MS group. Only GCE 100 group that showed a significant decrease in HDL level. GCE 100 mg/bw and 200 mg/bw group showed significantly higher adiponectin level compared to that of MS and DMS group. Furthermore, GCE 100, GCE 200, and DMS group showed a significant lower HOMA-IR index compared to that of MS group. Conclusion: 7 weeks GCE administration could decrease fasting blood glucose, profile lipid, blood pressure, and improved adiponectin level and HOMA-IR index.

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Section: Lukitasari Et Alsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Light-Roasted Green Coffee Extract Improved Adiponectin, Insulin Resistance, and Metabolic Profile of Metabolic Syndrome Rat Model

Lukitasari

Nugroho

Rohman

et al. 2017

Asian J Pharm Clin Res

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“…In addition, HWGT significantly lowered insulin levels and HOMA-IR values at weeks 2 and 4 of the experiment. It may be postulated that chlorogenic acid, one of the active components in HWGT, can stimulate insulin sensitivity and improve insulin resistance [15].…”

Section: Discussionmentioning

confidence: 99%

“…In our previous studies, GT extracts showed antioxidant activity demonstrated by a series of models in vitro and hepatoprotection in vivo [14], and major phenolic components, luteolin-7-glucoside and chlorogenic acid, were determined in hot water extract [14]; the latter component was recently showed to improve glucose tolerance and increase insulin sensitivity [15]. However, it is still unclear whether GT exhibits an inhibitory effect on α-glucosidase in vitro and hypoglycemic effect in an animal model.…”

Section: Introductionmentioning

confidence: 99%

Hypoglycemic and Antioxidative Effects of <i>Glossogyne tenuifolia</i> on Streptozotocin-Nicotinamide-Induced Diabetic Rats

Wang¹,

Huang²,

Hsu³

et al. 2017

AJPS

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Glossogyne tenuifolia (GT) is the traditional herbal tea in Penghu Island, Taiwan. Recent research has shown that the active components in GT are potential inhibitors of α-glucosidase. The present study investigated that whether or not GT could improve the status of type 2 diabetes mellitus. Male Wistar rats aged eight weeks were induced to be hyperglycemic by subcutaneous injection of streptozotocin-nicotinamide (STZ-NA) and combination of high-fat diet (HFD). The animals were given GT extracts at the low dose or high dose, or the anti-diabetic drug (acarbose), in drinking water for 4 weeks. The results showed that hot water extracts from GT resulted in significantly decreases in fasting blood glucose at the 1 st and 2 nd weeks, fasting insulin levels at the 2 nd week, 1 hour postprandial blood glucose after the starch tolerance test on Day 23 and blood glucose levels after oral glucose tolerance test (OGTT) at the 60 th minute on Day 25. In addition, diabetic rats treated with GT extracts from hot water for 4 weeks displayed significantly decreased thiobarbituric acid reactive substances (TBARS) in the serum, liver and kidney, serum total cholesterol, fasting insulin levels and homeostasis model assessment for insulin resistance (HOMA-IR). Overall, these results demonstrate that the hot water extracts of GT might improve the progression of diabetes and decrease oxidative stress in STZ-NA-induced diabetic rats.

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“…Even though it is not known yet whether the active components of coffee interact with TrkB directly or indirectly, several studies show that major components in coffee can modulate phosphorylation. Caffeic acid inhibits ERK phosphorylation in endothelial cells [22], and chlorogenic acid activates the AMP-activated protein kinase in skeletal muscle cells [23]. Alternatively, the activation of phosphatases, which may regulate TrkB autophosphorylation negatively [24], is another possible mechanism for the coffee-induced reduction of TrkB phosphorylation.…”

Section: Discussionmentioning

confidence: 99%

Coffee Modulates the Function of Brain-Derived Neurotrophic Factor (BDNF) in Human Neuroblastoma SH-SY5Y Cells

Kakio¹,

Nakazawa²,

Funakoshi‐Tago³

et al. 2015

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Recent epidemiological studies showed that daily coffee consumption is associated with a lower risk for several neurological disorders such as Alzheimer's disease and Parkinson's disease; however, the molecular mechanisms responsible for the protective effect of coffee against neurological disorders have not been elucidated. As brain-derived neurotrophic factor (BDNF) promotes neuronal survival and protects against neuronal damage, we investigated the effects of coffee on BDNF signaling using human neuroblastoma SH-SY5Y cells. We found that brewed coffee exerted an inhibitory effect on the autophosphorylation of tropomyosin receptor kinase B (TrkB), a BDNF receptor. Additionally, coffee reduced the phosphorylation of Akt in BDNF-treated SH-SY5Y cells. Treatment with coffee did not affect the TrkB receptor on the cell surface. The major constituents of coffee, such as caffeine, caffeic acid, chlorogenic acid, and trigonelline had no effect on TrkB phosphorylation induced by BDNF. In addition, coffee reduced the BDNF-induced increase in BDNF gene expression and the neurite outgrowth promoted by BDNF. Our data suggest that the protective effect of coffee reported in epidemiological studies against neurological disorders may not be associated with BDNF signaling through TrkB.

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Anti-diabetic and anti-lipidemic effects of chlorogenic acid are mediated by ampk activation

Cited by 336 publications

References 37 publications

Light-Roasted Green Coffee Extract Improved Adiponectin, Insulin Resistance, and Metabolic Profile of Metabolic Syndrome Rat Model

Light-Roasted Green Coffee Extract Improved Adiponectin, Insulin Resistance, and Metabolic Profile of Metabolic Syndrome Rat Model

Hypoglycemic and Antioxidative Effects of <i>Glossogyne tenuifolia</i> on Streptozotocin-Nicotinamide-Induced Diabetic Rats

Coffee Modulates the Function of Brain-Derived Neurotrophic Factor (BDNF) in Human Neuroblastoma SH-SY5Y Cells

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Anti-diabetic and anti-lipidemic effects of chlorogenic acid are mediated by ampk activation

Cited by 336 publications

References 37 publications

Light-Roasted Green Coffee Extract Improved Adiponectin, Insulin Resistance, and Metabolic Profile of Metabolic Syndrome Rat Model

Light-Roasted Green Coffee Extract Improved Adiponectin, Insulin Resistance, and Metabolic Profile of Metabolic Syndrome Rat Model

Hypoglycemic and Antioxidative Effects of &lt;i&gt;Glossogyne tenuifolia&lt;/i&gt; on Streptozotocin-Nicotinamide-Induced Diabetic Rats

Coffee Modulates the Function of Brain-Derived Neurotrophic Factor (BDNF) in Human Neuroblastoma SH-SY5Y Cells

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Hypoglycemic and Antioxidative Effects of <i>Glossogyne tenuifolia</i> on Streptozotocin-Nicotinamide-Induced Diabetic Rats