Hypoglycemic and Antioxidative Effects of <i>Glossogyne tenuifolia</i> on Streptozotocin-Nicotinamide-Induced Diabetic Rats

Abstract

Glossogyne tenuifolia (GT) is the traditional herbal tea in Penghu Island, Taiwan. Recent research has shown that the active components in GT are potential inhibitors of α-glucosidase. The present study investigated that whether or not GT could improve the status of type 2 diabetes mellitus. Male Wistar rats aged eight weeks were induced to be hyperglycemic by subcutaneous injection of streptozotocin-nicotinamide (STZ-NA) and combination of high-fat diet (HFD). The animals were given GT extracts at the low dose or high dose, or the anti-diabetic drug (acarbose), in drinking water for 4 weeks. The results showed that hot water extracts from GT resulted in significantly decreases in fasting blood glucose at the 1 st and 2 nd weeks, fasting insulin levels at the 2 nd week, 1 hour postprandial blood glucose after the starch tolerance test on Day 23 and blood glucose levels after oral glucose tolerance test (OGTT) at the 60 th minute on Day 25. In addition, diabetic rats treated with GT extracts from hot water for 4 weeks displayed significantly decreased thiobarbituric acid reactive substances (TBARS) in the serum, liver and kidney, serum total cholesterol, fasting insulin levels and homeostasis model assessment for insulin resistance (HOMA-IR). Overall, these results demonstrate that the hot water extracts of GT might improve the progression of diabetes and decrease oxidative stress in STZ-NA-induced diabetic rats.

Hepato-protective effects of Glossogyne tenuifolia in Streptozotocin-nicotinamide-induced diabetic rats on high fat diet

“…Extracts of GT are traditionally been used to prepare herbal drink that provide protection against sunstroke but there is a long history of it being used as a remedy in the local Folk medicine for their antipyretic, hepatoprotective and anti-inflammatory effects [15, 16, 19–23]. Administration of GT extract in Streptozotocin (STZ)–nicotinamide (NA)-induced diabetic rats have shown to inhibit α-glucosidase in vitro and enhance anti-oxidative capacity and hypoglycemic effect [15, 24]. Several bioactive principles in GT extracts have been identified and shown to provide both anti-inflammatory and anti-viral effects with respect to production of signaling mediators, like TNF-alpha, IL-6 and IFN-gamma, in human blood [25, 26].…”

Effect of irisin on metabolic and platelet functions in type 2 diabetic rats: role of soluble receptor of advanced glycation end products (sRAGE)

“…Additionally, the combination of high fat diet (HFD) with STZ has been reported to induce IR and hyperglycemia [18]. Nicotinamide has been shown to mediate a partial protection against cellular damage induced by STZ [19]; thus, this animal model mimics human T2DM with IR [10,20].…”

“…A second dose of NA and STZ were administered 24 h later. After induction, the animals in this group were switched to a high fat diet (40% energy from fat) [10]. A week later, rats with a fasting blood glucose (FBG) between 180 and 220 mg/dL were considered diabetic and included in the study [11].…”

Anti-Fatigue and Exercise Performance Improvement Effect of Glossogyne tenuifolia Extract in Mice

“…In our previous studies, we showed that GT extract has antioxidant and hepatoprotective activities against acetaminophen-induced hepatotoxicity and high-fat-diet-induced diabetes [ 14 , 18 ]. Furthermore, we have also shown the hypoglycemic and hypolipidemic effects of GT extracts in animal models [ 13 , 19 ]. We have also shown the presence of major phenolic compounds, such as luteolin, luteolin-7-glucoside, and oleanolic acid, in GT extract by HPLC analysis Figure 1 [ 14 , 18 , 20 ].…”