Anti-diabetic drugs recent approaches and advancements

Dowarah, Jayanta; Singh, Ved Prakash

doi:10.1016/j.bmc.2019.115263

Cited by 156 publications

(76 citation statements)

References 274 publications

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“…In addition, prolonged sulfonylurea's use is associated with progressive deterioration in β cell function, whereas the most common side effects of GLP-1 analogues are vomiting, nausea, diarrhea, and injection-site reactions [8]. The most common side effects of DPP-4 inhibitors are headache, nasopharyngitis, nausea, and excessive touchiness [9]. The side effects of α-glucosidase inhibiting drugs include diarrhea, abdominal pain, and flatulence [10] while urogenital tract infections, reduction in bone formation, orthostatic hypotension, euglycaemic ketoacidosis, and the volume depletion are adverse effects of SGLT2 inhibitors [2].…”

Section: Introductionmentioning

confidence: 99%

Lysophosphatidylcholine Containing Anisic Acid Is Able to Stimulate Insulin Secretion Targeting G Protein Coupled Receptors

et al. 2020

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Diabetes mellitus is a worldwide health problem with high rates of mortality and morbidity. Management of diabetes mellitus by dietary components is achievable especially at the initial stage of the disease. Several studies confirmed the antidiabetic activities of simple phenolic acids and lysophosphatidylcholine (LPC). The main goal of this study was to identify new potential insulin secretion modulators obtained by combining the structures of two natural compounds, namely O-methyl derivatives of phenolic acids and phospholipids. LPC and phosphatidylcholine bearing methoxylated aromatic carboxylic acids were tested as potential agents able to improve glucose-stimulated insulin secretion (GSIS) and intracellular calcium mobilization in MIN6 β pancreatic cell line. Our results show that LPC with covalently bonded molecule of p-anisic acid at the sn-1 position was able to induce GSIS and intracellular calcium flux. Notably, 1-anisoyl-2-hydroxy-sn-glycero-3-phosphocholine did not affect the viability of MIN6 cells, suggesting its potential safe use. Furthermore, we have shown that three G protein coupled receptors, namely GPR40, GPR55, and GPR119, are targeted by this LPC derivative.

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Section: Introductionmentioning

confidence: 99%

Lysophosphatidylcholine Containing Anisic Acid Is Able to Stimulate Insulin Secretion Targeting G Protein Coupled Receptors

et al. 2020

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“…Deficiency in insulin secretion, insulin action or both, results in chronic hyperglycemia, the main characteristic of diabetes mellitus [51], the main treatment to this condition being the use of anti-diabetic drugs that can control glucose levels in the blood [52].…”

Section: Antidiabeticmentioning

confidence: 99%

Uncharted Source of Medicinal Products: The Case of the Hedychium Genus

2020

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A current research topic of great interest is the study of the therapeutic properties of plants and of their bioactive secondary metabolites. Plants have been used to treat all types of health problems from allergies to cancer, in addition to their use in the perfumery industry and as food. Hedychium species are among those plants used in folk medicine in several countries and several works have been reported to verify if and how effectively these plants exert the effects reported in folk medicine, studying their essential oils, extracts and pure secondary metabolites. Hedychium coronarium and Hedychium spicatum are the most studied species. Interesting compounds have been identified like coronarin D, which possesses antibacterial, antifungal and antitumor activities, as well as isocoronarin D, linalool and villosin that exhibit better cytotoxicity towards tumor cell lines than the reference compounds used, with villosin not affecting the non-tumor cell line. Linalool and α-pinene are the most active compounds found in Hedychium essential oils, while β-pinene is identified as the most widespread compound, being reported in 12 different Hedychium species. Since only some Hedychium species have been investigated, this review hopes to shed some light on the uncharted territory that is the Hedychium genus.

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“…It is due, in 85-90% of total cases, to the poor or no response of receptors to insulin (type 2 diabetes mellitus), that increase blood glucose levels. Alternatively, type 1 diabetes mellitus, more frequent in children and teenagers, is imputable to the lack or deficiency of insulin, depending on the inability of pancreatic cells to produce it [168]. Diabetes is frequently associated to several complications, most notably cardiovascular and metabolic disorders.…”

Section: Antidiabetic Activitymentioning

confidence: 99%

“…One of the therapeutic approaches to treat diabetes consists of the inhibition of carbohydrate-hydrolyzing enzymes (such as α-amylase and α-glucosidase). The former is responsible for the breakdown of polysaccharides such as starch to monosaccharides [169], the latter breaks down carbohydrates into monosaccharide glucose, allowing its absorption by the intestine [168]. Acarbose, miglitol and voglibose, as well as other synthetic enzyme inhibitors, reduce the absorption rate of glucose, causing a reduction in postprandial glucose levels [170].…”

Section: Antidiabetic Activitymentioning

confidence: 99%

So Uncommon and so Singular, but Underexplored: An Updated Overview on Ethnobotanical Uses, Biological Properties and Phytoconstituents of Sardinian Endemic Plants

Sanna

Maxia

Fenu

et al. 2020

Plants

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The last decades have recorded an increase of plant-based drug discovery processes. Indeed, natural products possess a superior chemical diversity as compared to synthetic ones, leading to a renewal in searching for new therapeutic agents from the plant kingdom. In particular, since the structural variety of natural compounds reflects the biodiversity of their source organisms, regions of the world with high biodiversity and endemism deserve particular interest. In this context, Sardinia Island (Italy), with 290 endemic taxa (12% of the total flora), is expected to provide unique and structurally diverse phytochemicals for drug development. Several research groups built up a large program dedicated to the analysis of Sardinian endemic species, highlighting their peculiar features, both in respect of phytochemical and biological profiles. On this basis, the aim of this review is to provide an up-to-date and comprehensive overview on ethnobotanical uses, biological properties and phytoconstituents of Sardinian endemic plants in order to support their beneficial potential and to provide input for future investigations. We documented 152 articles published from 1965 to June 2020 in which a broad range of biological activities and the identification of previously undescribed compounds have been reported, supporting their great value as sources of therapeutic agents.

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Anti-diabetic drugs recent approaches and advancements

Cited by 156 publications

References 274 publications

Lysophosphatidylcholine Containing Anisic Acid Is Able to Stimulate Insulin Secretion Targeting G Protein Coupled Receptors

Lysophosphatidylcholine Containing Anisic Acid Is Able to Stimulate Insulin Secretion Targeting G Protein Coupled Receptors

Uncharted Source of Medicinal Products: The Case of the Hedychium Genus

So Uncommon and so Singular, but Underexplored: An Updated Overview on Ethnobotanical Uses, Biological Properties and Phytoconstituents of Sardinian Endemic Plants

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