Anti‑diabetic effect of the lupinalbin A compound isolated from <i>Apios americana</i>: <i>In vitro</i> analysis and molecular docking study

Kim, Hyo‐Young; Kim, Young Ho; Jeong, Hye Gwang; Jin, Chang Hyun

doi:10.3892/br.2021.1415

Cited by 5 publications

(3 citation statements)

References 6 publications

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“…Alpha-glucosidase inhibitory activity refers to the ability of a substance to reduce the activity of the alpha-glucosidase enzyme [ 7 ]. This enzyme is responsible for breaking down complex sugars into simpler forms that can be absorbed by the body.…”

Section: Resultsmentioning

confidence: 99%

“…Natural substances remain a significant factor in the process of developing drugs, with bioactive chemicals discovered from historically medicinal herbs serving as major sources of therapeutic agents for a number of diseases. The development of α-glucosidase inhibitors from natural products, such as acarbose, miglitol, and nojirimycin, has been crucial for managing type 2 diabetes [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

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Alpha-Glucosidase Inhibitory Activity of Saponins Isolated from Vernonia gratiosa Hance

Cong

Anh

Vinh

et al. 2023

J. Microbiol. Biotechnol.

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Species belonging to the Vernonia (Asteraceae), the largest genus in the tribe Vernonieae (consisting of about 1,000 species), are widely used in food and medicine. These plants are rich sources of bioactive sesquiterpene lactones and steroid saponins, likely including many as yet undiscovered chemical components. A phytochemical investigation resulted in the separation of three new stigmastane-type steroidal saponins (1 – 3), designated as vernogratiosides A–C, from whole plants of V. gratiosa . Their structures were elucidated based on infrared spectroscopy (IR), one-dimensional (1D) and two-dimensional nuclear magnetic resonance (2D NMR), high-resolution electrospray ionization mass spectrometry (HR-ESI-MS), and electronic circular dichroism analyses (ECD), as well as chemical reactivity. Molecular docking analysis of representative saponins with α-glucosidase inhibitory activity was performed. Additionally, the intended substances were tested for their ability to inhibit α-glucosidase activity in a laboratory setting. The results suggested that stigmastane-type steroidal saponins from V. gratiosa are promising candidate antidiabetic agents.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Alpha-Glucosidase Inhibitory Activity of Saponins Isolated from Vernonia gratiosa Hance

Cong

Anh

Vinh

et al. 2023

J. Microbiol. Biotechnol.

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“…The lowest KI value for the dcSTX ligand was 2.22 µM. The smaller value of KI indicates the smaller concentration of the ligand required to inhibit the target receptor (Kim et al, 2021). Based on the KI value, the interaction of the dcSTX ligand was more effective in inhibiting the NaV1.5 receptor in a small concentration than the STX and neoSTX ligands.…”

Section: Nav15 Receptormentioning

confidence: 97%

In Silico Molecular Docking Studies of Ovarian Extract Singkarak Lake Pufferfish (Tetraodon Leiurus) Against Breast Cancer

Hanif

Tjong

Syaifullah

et al. 2022

J microb biotech food sci

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Targets the development of breast cancer chemoprevention by blocking the expression of NaV 1.5 channels and NHE, decreasing the expression of Bcl-2 and Bcl-XL, and increasing the expression of Bax. The ovarian extract Singkarak Lake Pufferfish (Tetraodon leiurus) has the potential as chemoprevention in breast cancer cell lines (MCF-7). This study aimed to analyze the interaction of STX, neoSTX, and dcSTX ligands against NaV1.5, NHE, Bcl-2, Bcl-XL, and Bax receptors. This study used the molecular docking method using STX, neoSTX, and dcSTX ligands against NaV1.5, NHE, Bcl-2, Bcl-XL, and Bax receptors. The result showed that the STX ligand has a more stable interaction with NaV1.5, Bcl-2, Bcl-XL, and Bax receptors with ΔG values of -8.72, -7.32 -6.86, and -6.31 kcal/mol compared to neoSTX and dcSTX ligands. Furthermore, the neoSTX ligand has a more stable interaction with the NHE receptor with an ΔG value of -7.5 kcal/mol compared to the STX and dcSTX ligands. This study shows that the ovarian extract of Singkarak Lake Pufferfish (Tetraodon leiurus) has the potential to be developed as cancer chemoprevention.

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Metabolomics and chemometrics depict the changes in the chemical profile of white lupine (Lupinus albus L.) bioactive metabolites during seed germination

et al. 2023

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Anti‑diabetic effect of the lupinalbin A compound isolated from Apios americana: In vitro analysis and molecular docking study

Cited by 5 publications

References 6 publications

Alpha-Glucosidase Inhibitory Activity of Saponins Isolated from Vernonia gratiosa Hance

Alpha-Glucosidase Inhibitory Activity of Saponins Isolated from Vernonia gratiosa Hance

In Silico Molecular Docking Studies of Ovarian Extract Singkarak Lake Pufferfish (Tetraodon Leiurus) Against Breast Cancer

Metabolomics and chemometrics depict the changes in the chemical profile of white lupine (Lupinus albus L.) bioactive metabolites during seed germination

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