Anti-diabetic effects of Korean red pepper via AMPK and PPAR-γ activation in C2C12 myotubes

Yang, Hye Jeong; Jang, Dai-Ja

doi:10.1016/j.jff.2012.02.016

Cited by 18 publications

(10 citation statements)

References 31 publications

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“…The activation of AMPK has been suggested to be a potential therapeutic strategy for metabolic syndrome and diabetes (Chang et al, 2011;Wu et al, 2013;Yang, Jang, & Hwang, 2012). The results confirmed that 9 and 10 both activate AMPK (Fig.…”

Section: Discussionsupporting

confidence: 70%

Constituents of the stem of Cucurbita moschata exhibit antidiabetic activities through multiple mechanisms

Chang

Hsu

et al. 2014

Journal of Functional Foods

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Section: Discussionsupporting

confidence: 70%

Constituents of the stem of Cucurbita moschata exhibit antidiabetic activities through multiple mechanisms

Chang

Hsu

et al. 2014

Journal of Functional Foods

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“…AMPK activation and PTP-1B inhibition are both suggested to be potential strategies for treating and/or preventing type 2 diabetes (Hardie, 2013;Popov, 2011;Wu et al, 2013;Yang, Jang, & Hwang, 2012). Therefore, as AMPK activators and PTP-1B inhibitors, DHM and THC have the potential to be applied in treating insulin resistance and type 2 diabetes.…”

Section: Mechanisms Underlying the Actions Of Dhm And Thcmentioning

confidence: 99%

Bitter melon triterpenes work as insulin sensitizers and insulin substitutes in insulin-resistant cells

Chang

Chou

Liao

et al. 2015

Journal of Functional Foods

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“…The phenolic contents in the extracts were determined by the Folin-Ciocalteu method, using gallic acid as the standard (Yang et al, 2012). Briefly, 1 mL of the sample was added to 0.1 mL of 2 N Folin-Ciocalteu reagent.…”

Section: Determination Of Total Phenolic Contentsmentioning

confidence: 99%

“…Western blotting was performed as described previously (Yang et al, 2012). Briefly, after harvesting cells with the lysis buffer [50 mM Tris HCl, 1% Triton X-100, 0.5% sodium deoxycholate, 150 mM sodium chloride (NaCl), 1 mM ethylenediaminetetraacetic acid (EDTA), 1 mM phenylmethylsulfonyl fluoride (PMSF), 1 mM sodium orthovanadate, 1 mM NaF and 0.2% protease inhibitor cocktail; pH 7.2], equal amounts of proteins were separated using 10% SDS-PAGE and were transferred onto a nitrocellulose membrane.…”

Section: Western Blottingmentioning

confidence: 99%

Boehmeria niveaattenuates LPS-induced inflammatory markers by inhibiting p38 and JNK phosphorylations in RAW264.7 macrophages

Sung

Davaatseren

Kim

et al. 2013

Pharmaceutical Biology

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Context: Boehmeria nivea (Linn.) Gaudich (Urticaceae), a natural herb, has a long history of treating several diseases including wound healing. However, the anti-inflammatory effect of B. nivea has not been investigated. Objective: We investigated whether the 70% ethanol extract of B. nivea (Ebn) can exert antiinflammatory activity. Several phenolic compounds of extracts were determined to provide further information on the correlation between anti-inflammatory effects and phenolic compounds. Materials and methods: We prepared a 70% ethanol extract of B. nivea leaves and evaluated its anti-inflammatory activity (200, 400, 800, 1200 mg/mL) by measuring the secretions of nitric oxide (NO), tumor necrosis factor alpha (TNF-a) and interleukin 6 (IL-6), which were stimulated by lipopolysaccharide (LPS) in RAW264.7 macrophages. The total phenolic compounds were determined by the Folin-Ciocalteu method and major compounds were determined by HPLC. Results: Ebn was able to abolish the LPS-induced secretions of NO, TNF-a and IL-6. It also decreased the protein levels (IC 50 ¼ 186 mg/mL) of LPS-induced inducible nitric oxide synthase (iNOS). The LPS stimulated p38, JNK and ERK phosphorylations significantly more than the controls. Surprisingly, although Ebn reduced p38 and JNK phosphorylations, it did not influence ERK phosphorylation. We found that Ebn revealed several major compounds such as chlorogenic acid (1.96 mg/100 g), rutin (46.48 mg/100 g), luteolin-7-glucoside (11.29 mg/100 g), naringin (1.13 mg/100 g), hesperidin (23.69 mg/100 g) and tangeretin (1.59 mg/100 g). Discussion and conclusion: Boehmeria nivea exerts an anti-inflammatory effect on macrophages by inhibiting p38 and JNK, suggesting that it may be used as a functional ingredient against inflammation.

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Anti-diabetic effects of Korean red pepper via AMPK and PPAR-γ activation in C2C12 myotubes

Cited by 18 publications

References 31 publications

Constituents of the stem of Cucurbita moschata exhibit antidiabetic activities through multiple mechanisms

Constituents of the stem of Cucurbita moschata exhibit antidiabetic activities through multiple mechanisms

Bitter melon triterpenes work as insulin sensitizers and insulin substitutes in insulin-resistant cells

Boehmeria niveaattenuates LPS-induced inflammatory markers by inhibiting p38 and JNK phosphorylations in RAW264.7 macrophages

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