Anti-diabetic potentials of Momordica charantia and Andrographis paniculata and their effects on estrous cyclicity of alloxan-induced diabetic rats

Reyes, Beverly A.S.; Bautista, N.D.; Tanquilut, Neil; Anunciado, Rea Victoria P.; Leung, Albert B.; Sanchez, Geraldine C.; Magtoto, Ronaldo; Castronuevo, P.; Tsukamura, Hiroko; Maeda, Kei

doi:10.1016/j.jep.2005.10.018

Cited by 116 publications

(49 citation statements)

References 38 publications

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“…In general, serum glucose level of broilers fed on A. paniculata was lowered. The A. paniculata effect in the present study was similar with Reyes et al (2006) and Zhang and Tan (2000) who reported that A. paniculata led to a significant reduction of blood glucose levels indicating a hypoglycaemic effect. In contrast, Mathivanan and Kalaiarasi (2007) did not observe a significant difference in glucose level between A. paniculata and control groups.…”

Section: Discussionsupporting

confidence: 91%

Influence of Hempedu bumi (Andrographis paniculata) on serum biochemical parameters and liver morphology in broiler chickens

Malahubban

Aziz

2018

jaar

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Serum biochemical parameters and liver morphology were evaluated in broilers fed diets supplemented with hempedubumi (Andrographis paniculata, AP) ground leaf. Birds (n = 160) were assigned in four treatment groups with five replications and each group contain eight birds. Broilers in the control group were fed the basal diet without additives, the group dietary treatments, Diet AP2 (Basal diet + 2g/kg Andrographis paniculata); Diet AP4 (Basal diet + 4g/kg Andrographis paniculata) and Diet AP8 (Basal diet + 8g/kg Andrographis paniculata). During day-21 and day-42, five birds from each treatment groups were randomly selected for serum biochemical analysis which involves pancreatic, renal, and hepatic functions (aspartate transaminase (AST), alkaline transaminase (ALT), alkaline phosphatase (ALP), glucose, cholesterol, triglycerides, total protein, albumin, urea, sodium, potassium, chlorine, and globulins). Liver morphology was determined after slaughtering two birds and collected the liver samples. Based on these results, AP at 8g/kg diet lowered serum cholesterol, glucose, and triglycerides. It also maintains the normal structure of liver indicating that no toxic effect from AP supplementation at a rate up to 8 g/kg, it also that AP lowered ALP and ALT in blood of chicken. In conclusion, supplementation of AP at 8g/kg in diet has the potential to contribute good health and safe for broiler chicken.

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Section: Discussionsupporting

confidence: 91%

Influence of Hempedu bumi (Andrographis paniculata) on serum biochemical parameters and liver morphology in broiler chickens

Malahubban

Aziz

2018

jaar

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“…Antihyperglycemic effect may also be caused by the effect of plant extract on β-cells to release insulin or activate the insulin receptors to absorb the blood sugar and stimulate the peripheral glucose consumption [32][33] . In light of the results, our study indicates that Acacia Arabica and Withania coagulans extracts have good antidiabetic activity.…”

Section: Resultsmentioning

confidence: 99%

“…It has previously been widely used to induce diabetes mellitus in experimental animal models, allowing investigation of hypoglycemic agents in the treatment of diabetes. [22,23] Alloxan injection consistently produced symptoms characteristic of diabetes mellitus including hyperglycemia, decreased insulin levels, polyurea and weight loss [33] . In our approach, we demonstrated the efficacy of Alloxan through the glibenclamide studies in diabetic rats as well as in normal hyperglycemic rats [8] .…”

Section: Acacia Arabica and Withania Coagulans Extract Studiesmentioning

confidence: 99%

Hypoglycemic and Antihyperglycemic Effects of Different Extracts and Combinations of Withania coagulans Dunal and Acacia arabica Lamk in Normal and Alloxan Induced Diabetic Rats

Yasir¹,

Sinha²,

Preteek³

et al. 2012

Phcog Commn

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“…The treated groups were given 0.5g/kg, 1g/kg and 2g/kg body weight (P.O) of extract daily for 28 days, the control group was given 10ml/kg of distilled water (P.O) daily for 28 days. The doses of the extract chosen were based on the accepted method 18 . On the 28 th day, the animals were anaesthetized with chloroform in a chamber and blood collected from the abdominal aorta for biochemical and haematological assays.…”

Section: Acute Toxicological Experimentmentioning

confidence: 99%

Untitled

2014

IJPSR

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ABSTRACT:The World Health Organization (WHO) defines traditional medicine as "the health practices, approaches, knowledge and beliefs incorporating plants, animals and mineral-based medicines, spiritual therapies, manual techniques and exercises, applied singularly or in combination to treat, diagnose and prevent illness or maintain wellbeing. Various compounds have been isolated from Bridelia micrantha some of which are Friedelin, Taraxeronie, Epifiedelinol, Taraxerol, Garlic acid, Ellagic acid and sitosterol. Fresh stems of B. micrantha collected, dried, pulverized and mixed with sterile distilled water, extract left for 72hrs and stirred at 3hourly, filtered and concentrated in a water bath, stored in a refrigerator. Experiments were carried out using mice and wister rats of both sexes. The LD 50 following the intraperitoneal route was estimated to be 20.3 mg/kg. The surviving animals following intraperitoneal route exhibited toxicological signs of writhing, decrease loco-motor activity, sedation and dose dependant mortality. Haematological parameters in the rat after 28days of daily oral administration show no significant difference between the treated groups and control. However, lymphocytes at the dose of 1000mg/kg indicate significant difference with control (p<0.05). The highest dose used in this study is 2g/kg which is quite high; the use of much higher doses in toxicological test gives an idea of the safety margin of the extract. The extract of the dose of 2g/kg caused significant increase in the level of GGT, ALP and significant decrease at the level of ALT and total protein at all doses. On the other hand the extract did not cause any significant change in the level of AST, Total bilirubin, direct bilirubin and albumin and blood glucose.

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Anti-diabetic potentials of Momordica charantia and Andrographis paniculata and their effects on estrous cyclicity of alloxan-induced diabetic rats

Cited by 116 publications

References 38 publications

Influence of Hempedu bumi (Andrographis paniculata) on serum biochemical parameters and liver morphology in broiler chickens

Influence of Hempedu bumi (Andrographis paniculata) on serum biochemical parameters and liver morphology in broiler chickens

Hypoglycemic and Antihyperglycemic Effects of Different Extracts and Combinations of Withania coagulans Dunal and Acacia arabica Lamk in Normal and Alloxan Induced Diabetic Rats

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