Anti-diabetic properties of<i>Daphniphyllum macropodum</i>fruit and its active compound

Koo, Hyun Jung; Kwak, Jong Hwan; Kang, Se Chan

doi:10.1080/09168451.2014.923289

Cited by 6 publications

(4 citation statements)

References 31 publications

(29 reference statements)

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“…[36] For the first time, it demonstrated that the feasibility to achieve highly selective glycosylation by rational unity of the pK a value of the glycosyl acceptor. Lastly, when maltose (15) was used as the glycosyl donor to react with chrysin (2 a), chrysin-7-O-β-maltose ( 16) was isolated in 15% yield (Scheme 4), which showed that our procedure was also suitable for the glycosylation of disaccharides.…”

Section: Resultsmentioning

confidence: 88%

“…[2] A large number of new flavonoid glycosides are continually identified from natural products every year, the true number is thus far more than that. Flavonoid glycosides are of great benefit to human health and have shown an extensive range of pharmacological activities, including anti-inflammatory, [3,4] antioxidant, [5][6][7] anti-tumor, [8,9] antibacterial, [10][11][12] hypoglycemic [13][14][15] and neuroprotective activity. [16,17] Even though the wide distribution and biological activities only very few methodologies on the synthesis of flavonoid glycosides have been developed.…”

Section: Introductionmentioning

confidence: 99%

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1, 2‐trans‐Stereoselective 7‐O‐Glycosylation of Flavonoids with Unprotected Pyranoses by Mitsunobu Reaction

Shi

Yang

Cheng

et al. 2022

Chemistry An Asian Journal

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The glycosylation of protecting‐group‐free pyranoses with flavonoids to generate flavonoid O‐glycosides under Mitsunobu conditions was reported. The methodology allows to prepare a wide range of natural 7‐flavonoid O‐glycosides and their derivatives from commercially available chemicals in good to excellent yields with exclusive 1,2‐trans‐stereoselectivity regardless the anomeric configuration of employed pyranoses. The highly regioselective glycosylation was also achieved among different types of hydroxyl groups on the glycosyl acceptors.

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Section: Resultsmentioning

confidence: 88%

Section: Introductionmentioning

confidence: 99%

1, 2‐trans‐Stereoselective 7‐O‐Glycosylation of Flavonoids with Unprotected Pyranoses by Mitsunobu Reaction

Shi

Yang

Cheng

et al. 2022

Chemistry An Asian Journal

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“…Several reports have shown that this model displays insulin resistance and mildly impaired insulin secretion, both of which are distinct characteristics of the metabolic disturbances observed in patients with T2D (Zhang et al 2008;Koo et al 2014). The present study suggests that PMLE has potent hypoglycaemic and hypolipidaemic activities in STZ/HFD-induced T2D.…”

Section: Discussionmentioning

confidence: 88%

Prunus mumeleaf extract lowers blood glucose level in diabetic mice

Lee

Kwon

Lee

et al. 2016

Pharmaceutical Biology

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Context Diabetes is a common metabolic disease with long-term complications. Prunus mume Sieb. et Zucc. (Rosaceae) fruits have shown to ameliorate glucose intolerance. However, the antidiabetic effects of P. mume leaves have not been investigated. Objective This study evaluated the effects of P. mume leaf 70% ethanol extract (PMLE) on alleviating diabetes in vivo and in vitro. Materials and methods PMLE was fractionated into n-hexane, dichloromethane (CH 2 Cl 2 ), ethyl acetate (EtOAc), n-butanol (BuOH) and water. Polyphenol and flavonoid contents in PMLE fractions were determined using Folin-Ciocalteu reagent and the aluminium chloride colorimetric method, respectively. We evaluated a-glucosidase inhibition using a microplate reader at 400 nm. Adipocyte differentiation by lipid accumulation was measured using Nile Red staining. Male imprinting control region (ICR) mice were injected with streptozotocin (STZ, 100 mg/kg, i.p.). High-fat diets were provided for three weeks prior to PMLE treatments to induce type 2 diabetes. PMLE (0, 5, 25 or 50 mg/kg) was administrated for four weeks with high-fat diets. Results The EtOAc fraction of PMLE inhibited a-glucosidase activity (IC 50 ¼ 68.2 mg/mL) and contained 883.5 ± 14.9 mg/g of polyphenols and 820.1 ± 7.7 mg/g of flavonoids. The 50 mg/kg PMLE supplement reduced 40% of blood glucose level compared to obese/diabetes mice. Obese/diabetic mice treated with 50 mg/kg PMLE showed a lower level of triacylglycerol (320.7 ± 20.73 mg/dL) compared to obese/diabetes mice (494.9 ± 14.80 mg/dL). Conclusion The data demonstrate that P. mume leaves exert antidiabetic effects that may be attributable to high concentrations of polyphenols and flavonoids.ARTICLE HISTORY

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“…Next, we tested whether these actions of phellopterin ( 3 ) could improve insulin resistance and attenuate blood glucose levels, in the diabetic status of HFD/STZ-induced type Ⅱ diabetic mice. Because, the animal model by feeding with high-fat diet following STZ that would closely mimic the metabolism characteristics of human type II diabetes mellitus [14] . As shown in Table 2 and Fig.…”

Section: Resultsmentioning

confidence: 99%

Phellopterin isolated from Angelica dahurica reduces blood glucose level in diabetic mice

Han

Jeon

2018

Heliyon

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Insulin resistance is the critical condition for the development of metabolic syndromes including type II diabetes and heart disease. To investigate the active components of Angelica dahurica root which is known to increase insulin sensitivity, its methanol extract was subfractionated. The ethyl acetate (EtOAc) fraction of the Angelica dahurica root extract significantly promoted adipocyte differentiation in 3T3-L1 preadipocyte cells. Among the three compounds isolated from the EtOAc extract (bergapten (1), imperatorin (2) and phellopterin (3)), phellopterin (3) induced the highest adipocyte differentiation at 25 and 50 μg/mL. In addition, treatment with imperatorin (2) and phellopterin (3) increased the mRNA expression of peroxisome proliferator-activated receptors γ (PPARγ). In diabetic animal model induced by high-fat diets (HFD) and streptozotocin (STZ), administration of phellopterin ((3), 1 mg/kg and 2 mg/kg) significantly reduced the levels of blood glucose, triglycerides and total cholesterol. Taken together, these results indicate that phellopterin (3) enhances adipocytes differentiation in 3T3-L1 preadipocytes, phellopterin (3) significantly prevents HFD/STZ-induced type Ⅱ diabetes. The present study also provides phellopterin (3) may be a valuable therapeutic alternative for enhancing insulin sensitivity through promotion of adipocyte differentiation and by increasing mRNA expression levels of PPARγ, which is a major mediator of insulin sensitivity.

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Anti-diabetic properties ofDaphniphyllum macropodumfruit and its active compound

Cited by 6 publications

References 31 publications

1, 2‐trans‐Stereoselective 7‐O‐Glycosylation of Flavonoids with Unprotected Pyranoses by Mitsunobu Reaction

1, 2‐trans‐Stereoselective 7‐O‐Glycosylation of Flavonoids with Unprotected Pyranoses by Mitsunobu Reaction

Prunus mumeleaf extract lowers blood glucose level in diabetic mice

Phellopterin isolated from Angelica dahurica reduces blood glucose level in diabetic mice

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