Anti-Diabetic Property and Phytochemical Composition of Aqueous and Methanol Extracts of Buchholzia coriacea Seeds in Alloxan-Induced Diabetic Rats

Okolie, Amanda; Obiudu, I.K.; Agbafor, K. N.; Unaegbu, Marcellus; Engwa, Godwill Azeh; Obiudu, C.V

doi:10.3923/jms.2015.241.245

Cited by 6 publications

(3 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The increase in BMG, FER and PER observed in 2.5% VA groups treated group may be attributed to the antidiabetic potential of BC [9].…”

Section: Discussionmentioning

confidence: 77%

“…The seed is used as aphrodisiac in Cameroon, childbirth enhancer in Ivory Coast and antidiabetic agent in Nigerian ethnomedical practice. The antiulcer, analgesic, antidiabetic, anthelminthic, antibacterial, anti-inflammaory and antioxidant activities of B. coriacea have been reported [3][4][5][6][7][8][9]. There is paucity of information on the effects of Buchholzia coriacea on nutrient utilization and clinical biochemical parameters in alloxan-induced diabetes mellitus.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of Buchholzia coriacea Seed on Nutrient Utilization and Serum Biochemical Parameters in Alloxan-Induced Diabetic Rat

Amaechi

Ojimelukwe

Onoja

2018

J. Pharm. Nutr. Sci.

View full text Add to dashboard Cite

The effects of Buchholzia coriacea seed on the nutrient utilization and biochemical parameters in alloxan-induced diabetic rat were evaluated. Buchholzia coriacea (BC) seed was washed, sliced, dried, pulverized and mixed with standard ration at 2.5%, 5%, 10% and 20%. The proximate nutrient composition of the standard and prepared rations was determined. The Buchholzia coriacea incorporated rations and standard ration were fed to alloxan-induced diabetic rats for 70 consecutive days. The nutrient utilization and biochemical parameters as well as the histopathology of pancreas of the treated rats were evaluated. The Buchholzia coriacea at 2.5% inclusion rate significantly (p < 0.05) improved the nutrient utilization and biochemical parameters that were compromised in diabetic rats fed with standard ration alone. The B. coriacea also reversed the pancreatic islet damage induced by alloxan. Buchholzia coriacea have potent antidiabetic and hypolipidemic activities and should not be incorporation in excess of 5% in the diet.

show abstract

“…The increase in BMG, FER and PER observed in 2.5% VA groups treated group may be attributed to the antidiabetic potential of BC [9].…”

Section: Discussionmentioning

confidence: 77%

Section: Introductionmentioning

confidence: 99%

Effects of Buchholzia coriacea Seed on Nutrient Utilization and Serum Biochemical Parameters in Alloxan-Induced Diabetic Rat

Amaechi

Ojimelukwe

Onoja

2018

J. Pharm. Nutr. Sci.

View full text Add to dashboard Cite

show abstract

“…The phytochemical screening of Buchholzia coriacea seeds has shown that the seeds are rich in alkaloids, tannins, flavonoids, and saponins (Mbata, Duru, Onwumelu, 2009;Obiudu et al, 2015). Many medicinal plants with antibacterial and anti-malarial properties, which have been reported to be rich in these phytochemicals, are also reputed to have antifertility actions (Gupta, Sharma, 2006).…”

Section: Introductionmentioning

confidence: 99%

Buchholzia coriacea (wonderful kola) seeds induce male reproductive toxicity by suppressing the pituitary-gonadal axis in Wistar rats

Obembe¹

2021

Braz. J. Pharm. Sci.

View full text Add to dashboard Cite

The methanolic extract of Buchholzia coriacea seeds (MEBC) has been reported to induce male reproductive toxicity by decreasing sperm parameters and fertility index. To elucidate the possible mechanism(s), the effects of graded doses of MEBC on sex hormones and sperm profile were investigated in this study. The MEBC (e.g., 50, 200, 400, and 600 mg/kg) was administered daily (p.o.) to male Wistar rats for 6 weeks, while a concurrent control group received distilled water (vehicle). Then, the animals were sacrificed under sodium pentobarbital anaesthesia. Weights of organs were recorded, and the sperm profile was determined microscopically. Testosterone, luteinizing hormone (LH), and follicle stimulating hormone (FSH) were assayed from the obtained serum using the ELISA technique. Sperm motility was significantly reduced by MEBC (i.e., 50 and 200 mg/kg), and sperm count reduced in all treated groups in a dose-dependent manner compared with that of the control. Serum testosterone, LH, and FSH decreased in treated rats. A histopathological examination of testes showed a considerable depletion and necrosis of the epithelium of seminiferous tubules. The result suggests that Buchholzia coriacea seeds induce male reproductive toxicity by suppressing the pituitary-gonadal axis.

show abstract

An overview of anti-diabetic plants used in Gabon: Pharmacology and toxicology

Taika

Bouckandou

Souza

et al. 2018

Journal of Ethnopharmacology

View full text Add to dashboard Cite

show abstract

Anti-Diabetic Property and Phytochemical Composition of Aqueous and Methanol Extracts of Buchholzia coriacea Seeds in Alloxan-Induced Diabetic Rats

Cited by 6 publications

References 7 publications

Effects of Buchholzia coriacea Seed on Nutrient Utilization and Serum Biochemical Parameters in Alloxan-Induced Diabetic Rat

Effects of Buchholzia coriacea Seed on Nutrient Utilization and Serum Biochemical Parameters in Alloxan-Induced Diabetic Rat

Buchholzia coriacea (wonderful kola) seeds induce male reproductive toxicity by suppressing the pituitary-gonadal axis in Wistar rats

An overview of anti-diabetic plants used in Gabon: Pharmacology and toxicology

Contact Info

Product

Resources

About