Anti-edema effect of epigallocatechin gallate on spinal cord injury in rats

Ge, Rui; Zhu, Yuyan; Diao, Yun-Peng; Lin, Tao; Yuan, Wei; Xiong, Xiaolu

doi:10.1016/j.brainres.2013.06.009

Cited by 52 publications

(31 citation statements)

References 28 publications

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“…Among them, pinocembrin, a flavonoid contained in propolis, seems to be able to downregulate AQP-4 expression in a rodent model of focal cerebral ischemia (Gao et al, 2010); curcumin treatment reduced hypoxia-hypercapniainduced brain edema by downregulating the messenger RNA (mRNA) expression levels of AQP-4 in rats (Yu et al, 2016) and dampening AQP-4 and GFAP overexpression in a rat model of acute spinal cord injury (Nesic et al, 2010). Similar results were published with epigallocatechin gallate treatment, an essential ingredient of green tea (Ge et al, 2013). Acute administration of carvacrol, a terpenoid, dose-dependently attenuates brain edema induced by cerebral hemorrhage in mice by downregulating brain Aqp4 gene and protein expression, likely reducing astrocyte swelling (Nesic et al, 2010).…”

Section: Pharmacological Tools Targeting Aqp-4supporting

confidence: 54%

Altered Waste Disposal System in Aging and Alzheimer’s Disease: Focus on Astrocytic Aquaporin-4

et al. 2020

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Among the diverse cell types included in the general population named glia, astrocytes emerge as being the focus of a growing body of research aimed at characterizing their heterogeneous and complex functions. Alterations of both their morphology and activities have been linked to a variety of neurological diseases. One crucial physiological need satisfied by astrocytes is the cleansing of the cerebral tissue from waste molecules. Several data demonstrate that aquaporin-4 (AQP-4), a protein expressed by astrocytes, is crucially important for facilitating the removal of waste products from the brain. Aquaporins are water channels found in all district of the human organism and the most abundant isoform in the brain is AQP-4. This protein is involved in a myriad of astrocytic activities, including calcium signal transduction, potassium buffering, synaptic plasticity, astrocyte migration, glial scar formation and neuroinflammation. The highest density of AQP-4 is found at the astrocytic domains closest to blood vessels, the endfeet that envelop brain vessels, with low to zero expression in other astrocytic membrane regions. Increased AQP-4 expression and loss of polarization have recently been documented in altered physiological conditions. Here we review the latest findings related to aging and Alzheimer's disease (AD) on this topic, as well as the available knowledge on pharmacological tools to target AQP-4.

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Section: Pharmacological Tools Targeting Aqp-4supporting

confidence: 54%

Altered Waste Disposal System in Aging and Alzheimer’s Disease: Focus on Astrocytic Aquaporin-4

et al. 2020

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“…In most of these studies conducted in both rats [80,81,82,83] and mice [84,85], SCI contusion and compression [64,86,87,88,89] induced a common pattern of AQP4 up-regulation. These preclinical trials have recently been reviewed in detail by Yonan and Binder [90].…”

Section: Aqp Expression In Disease Conditions Of Spinal Cordmentioning

confidence: 99%

Aquaporins in the Spinal Cord

Oklinski

Skowroński

Skowrońska

et al. 2016

IJMS

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Aquaporins (AQPs) are water channel proteins robustly expressed in the central nervous system (CNS). A number of previous studies described the cellular expression sites and investigated their major roles and function in the brain and spinal cord. Among thirteen different mammalian AQPs, AQP1 and AQP4 have been mainly studied in the CNS and evidence has been presented that they play important roles in the pathogenesis of CNS injury, edema and multiple diseases such as multiple sclerosis, neuromyelitis optica spectrum disorders, amyotrophic lateral sclerosis, glioblastoma multiforme, Alzheimer’s disease and Parkinson’s disease. The objective of this review is to highlight the current knowledge about AQPs in the spinal cord and their proposed roles in pathophysiology and pathogenesis related to spinal cord lesions and injury.

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“…The anti-edema effect could be the result of down-regulation of the expression of Aquaporin-4 (AQP4) protein levels. Also EGCG may reduce astrogliosis after SCI through down-regulation the expression of glial fibrillary acidic protein (GFAP) levels in a SCI rat model (Ge et al, 2013).…”

Section: Anti-edema Propertiesmentioning

confidence: 99%

Therapeutic potential of flavonoids in spinal cord injury

Zhang

Hölscher

2017

Reviews in the Neurosciences

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AbstractSpinal cord injury (SCI) is a catastrophic event that can profoundly affect a patient’s life, with far-reaching social and economic effects. A consequential sequence of SCI is the significant neurological or psychological deficit, which obviously contributes to the overall burden of this condition. To date, there is no effective treatment for SCI. Therefore, developing novel therapeutic strategies for SCI is highly prioritized. Flavonoids, one of the most numerous and ubiquitous groups of plant metabolites, are the active ingredients of traditional Chinese medicine such as Scutellaria baicalensis Georgi (Huang Qin) or Ginkgo biloba (Ying Xin). Accumulated research data show that flavonoids possess a range of key pharmacological properties such as anti-inflammatory, anti-oxidant, anti-tumor, anti-viral, anti-cardiovascular disease, immunomodulatory, and neuroprotective effects. Based on this, the flavonoids show therapeutic potential for SCI diseases. In this paper, we will review the pharmacological properties of different types of flavonoids for the treatment of SCI diseases, and potential underlying biochemical mechanisms of action will also be described.

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Anti-edema effect of epigallocatechin gallate on spinal cord injury in rats

Cited by 52 publications

References 28 publications

Altered Waste Disposal System in Aging and Alzheimer’s Disease: Focus on Astrocytic Aquaporin-4

Altered Waste Disposal System in Aging and Alzheimer’s Disease: Focus on Astrocytic Aquaporin-4

Aquaporins in the Spinal Cord

Therapeutic potential of flavonoids in spinal cord injury

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