Anti‐Endothelial Autoantibodies in Patients With Sudden Hearing Loss

Ottaviani, F; Cadoni, Gabriella; Marinelli, Luca; Fetoni, Anna Rita; Santis, Antonella De; Romito, Anna; Vulpiani, P.; Manna, Raffaele

doi:10.1097/00005537-199907000-00014

Cited by 53 publications

(40 citation statements)

References 28 publications

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“…In addition to the above findings, our study indicates elevation of ANA (25.4%) in SSNHL patients with a prevalence greater than that seen in a normal patient population. The prevalence of ANA in patients with SSNHL has been studied and 17-43% of the patients have been reported to be ANA positive [Toubi et al, 2004;Ottaviani et al, 1999;Agrup and Luxon, 2006]. We confirmed the reported association of these autoantibodies with SSNHL, thereby further supporting the assumption that SSNHL is partially immune-mediated [Toubi et al, 2004].…”

Section: Discussionsupporting

confidence: 84%

Prevalence and Clinical Significance of Anticardiolipin, Anti-β<sub>2</sub>-Glycoprotein-1, and Anti-Heat Shock Protein-70 Autoantibodies in Sudden Sensorineural Hearing Loss

Gross

Eliashar²,

Ben-Yaakov³

et al. 2008

Audiol Neurotol

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Sudden sensorineural hearing loss (SSNHL) is frequently classified as ‘idiopathic’ since the causative factor responsible for its onset is not identified in most cases. In the present study, we determined whether SSNHL is clinically associated with serum anti-heat shock protein-70 (anti-HSP70) and antiphospholipids (anti-PLs) autoantibodies and whether these autoantibodies have an impact on the prognosis of SSNHL. Sera from 63 patients with SSNHL were screened prospectively for the presence of anti-HSP70 and anti-PLs autoantibodies by an enzyme-linked immunosorbent assay test. Anti-PLs antibodies in this study consisted of anticardiolipin, and anti-β₂-glycoprotein-1 antibodies. Serum was assayed for anti-HSP70 IgG antibodies using recombinant human HSP70. Demographic, clinical, and audiometric variables were analyzed to find the possible role of serum autoantibodies in SSNHL patients. Sixteen patients (25.4%) had demonstrable anti-HSP70 antibodies in serum. Twenty-one patients (33.3%) showed a positive result for at least one isotype (IgM or IgG) of anti-PLs. In 19% of the patients, anti-HSP70 and anti-PLs antibodies were positive in two combinations. A statistically significant association was found between anti-HSP70 antibodies and the Siegel recovery grade subgroup. SSNHL patients who were positive for anti-HSP70 antibodies showed a significantly higher rate of complete recovery and incomplete but partial recovery than SSNHL patients without anti-HSP70 antibodies (p = 0.0496). Statistically significant association was found between total anticardiolipin, total anti-β₂-glycoprotein-1, total anti-PLs, and anti-PLs in combination with anti-HSP70 antibodies and age (p = 0.0229). The detection of autoantibodies to HSP70 and PLs offers a pliable explanation for the immune-mediated mechanism of SSNHL. The present study confirms and supports previous studies regarding the association between anti-HSP70 and anti-PLs antibodies with SSNHL, and is the first to identify a positive association between anti-HSP70 antibodies and a positive outcome of SSNHL. Further studies are necessary in order to identify and further clarify the immunologic role of the presence of autoantibodies and their impact on the prognosis of SSNHL.

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Section: Discussionsupporting

confidence: 84%

Prevalence and Clinical Significance of Anticardiolipin, Anti-β<sub>2</sub>-Glycoprotein-1, and Anti-Heat Shock Protein-70 Autoantibodies in Sudden Sensorineural Hearing Loss

Gross

Eliashar²,

Ben-Yaakov³

et al. 2008

Audiol Neurotol

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“…Vertigo and/or ear noises represent possible additional symptoms [5]. According to the clearer and in literature more often used deWnition idiopathic sudden SNHL is deWned as hearing loss of >30 dB over at least three contiguous audiometric frequencies developing over <72 h without any identiWable cause [7][8][9][10]. DiVerent hypothesis for the genesis of ISSNHL have been discussed during the past decades [11,12].…”

Section: Introductionmentioning

confidence: 99%

Positive family history of idiopathic sudden sensorineural hearing loss

Gäckler

Eickelmann

Brors

et al. 2010

Eur Arch Otorhinolaryngol

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Idiopathic sudden sensorineural hearing loss (ISSNHL) is a heterogenic disease. Multiple factors influencing aetiology and prognosis are discussed. A retrospective clinical characterisation and analysis of family history of ISSNHL patients was performed to investigate influences on the disease. 186 inpatients diagnosed with ISSNHL were characterised by health records and a standardised questionnaire. Audiograms were observed. 75 controls that had never experienced an event of ISSNHL were questioned about family members being affected by ISSNHL. 63.4% of all patients could be assigned to at least one group with similar causes of ISSNHL (noise exposure, positive family history, infectious diseases, hypothyroidism and fibromuscular dysplasia). A positive family history for ISSNHL has not been reported so far. Therefore, we accentuated the characterisation of patients with positive family history. 21.4% affirmed a positive family history. In ten families, at least two family members were reported as ISSNHL patients. In comparison with patients with negative family history, they tend to be younger, experience more events of ISSNHL and show less improvement of hearing abilities under therapeutic treatment (non-significant). Differences intensified between smokers with positive family history and non-smokers with negative family history. Differences concerning average age were statistically significant (p = 0.001). Within 75 controls 11 families were reported with one member being affected by ISSNHL. In the control group we did not detect any family with more than one ISSNHL patient. The results indicated that patients with positive family history tend to have an aggravated course of ISSNHL. Further studies should help to confirm these results and to identify environmental or genetic factors leading to ISSNHL. This might support a better understanding of the aetiology of ISSNHL and offer new possibilities for prevention and therapy.

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“…1 Various etiological causes have been hypothesized, including vascular disorders, viral infections of the labyrinth or the cochlear nerve, or autoimmunological causes. 2 Whatever the cause of the hearing loss, impaired cochlear perfusion seems to be the most important event and, as the cochlea is highly sensitive to minimal changes in localized blood flow and anoxia, cochlear ischemia is a likely cause.…”

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confidence: 99%