Anti-fouling SERS-based immunosensor for point-of-care detection of the B7–H6 tumor biomarker in cervical cancer patient serum

Panikar, Sandeep Surendra; Banu, Nehla; Haramati, Jesse; Gutierrez-Silerio, Gloria Yareli; Bastidas-Ramírez, Blanca Estela; Téllez‐Bañuelos, Martha Cecilia; Camacho-Villegas, Tanya A.; Toro-Arreola, Susana del; Rosa, E. De la

doi:10.1016/j.aca.2020.09.019

Cited by 49 publications

(32 citation statements)

References 48 publications

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“…Alternatively, polymeric macromolecules, such as oligo(ethylene glycol) or zwitterionic polymers can also be used to repel contaminants from the enhancing surface to enable direct SERS analysis of bio-samples. [179][180][181] For example, Jiang, Yu, et al designed an optofluidic system functionalized with antifouling mixed SAMs which allowed quantitative SERS analysis of a variety of clinically relevant molecules in plasma to be achieved by flowing the drug containing plasma samples through the SERS enhancing channels, as shown in Figure 12D. 182 More specifically, the enhancing surface was first modified with a SAM of mercaptoundecyl bromoisobutyrate "initiator", which were used to graft chains of antifouling zwitterionic poly(carboxybetaine acrylamide) to form a mixed monolayer of initiators and zwitterionic polymers, as shown in Figure 12E.…”

Section: Intermolecular Interactions-based Separationmentioning

confidence: 99%

Towards practical and sustainable SERS: a review of recent developments in the construction of multifunctional enhancing substrates

Huang

et al. 2021

J. Mater. Chem. C

135

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Section: Intermolecular Interactions-based Separationmentioning

confidence: 99%

Towards practical and sustainable SERS: a review of recent developments in the construction of multifunctional enhancing substrates

Huang

et al. 2021

J. Mater. Chem. C

135

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show abstract

“…Many studies have been published over the recent year, where graphene and GRMs are utilised in biosensing platforms to detect proteins that are released from cancer cells, or other cells as a response to cancer [79,80]. A novel electrochemical-based sensor with rGO, thionine and gold nanocomposites was developed for the detection of CA125 [81].…”

Section: Graphene Based Biosensors For Protein Detectionmentioning

confidence: 99%

Graphene for Biosensing Applications in Point-of-Care Testing

Prattis

Hui

Gubeljak

et al. 2021

Trends in Biotechnology

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“…In view of a potential link between an increase in the level of oncoproteins and disease progression, a number of LFIA-based approaches that also provide quantitative results have been developed. A SERS-based analysis of two specific cervical cancer biomarkers comprising SCCA and CA125 in serum shows potential for multiplexed quantification [55]. An LFIA with magnetic focusing for improving the sensitivity of detection was proposed to measure valosin-containing protein in fresh frozen tissue, but has not yet been tested on relevant sample cohorts [56].…”

Section: Immunoassaysmentioning

confidence: 99%

Molecular markers for cervical cancer screening

Güzel

Hoff

Kok

et al. 2021

Expert Review of Proteomics

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This review gives an overview of current screening practices for cervical cancer. In the introduction, we will cover approaches of population screening focusing on high-risk Human Papilloma Virus (hrHPV) and the need for a better triage assay. We will further assess the impact of current vaccination programs on screening. Subsequently, the review will cover various technological aspects of nucleic acid-and protein-based biomarker assays. We will then detail different molecular markers in view of their use in triage assays, emphasizing epigenetic and protein markers. Finally, we will place this in the context of cost-effectiveness considerations in view of their implementation in high-as well as in low-to middle-income countries. Introduction: Cervical cancer remains a significant healthcare problem, notably in low-to middle-income countries. While a negative test for hrHPV has a predictive value of more than 99.5%, its positive predictive value is less than 10% for CIN2+ stages. This makes the use of a so-called triage test indispensable for population-based screening to avoid referring women, that are ultimately at low risk of developing cervical cancer, to a gynecologist. This review will give an overview of tests that are based on epigenetic marker panels and protein markers. Areas covered: There is a medical need for molecular markers with a better predictive value to discriminate hrHPV-positive women that are at risk of developing cervical cancer from those that are not. Areas covered are epigenetic and protein markers as well as health economic considerations in view of the fact that most cases of cervical cancer arise in low-to-middle-income countries. Expert opinion: While there are biomarker assays based on changes at the nucleic acid (DNA methylation patterns, miRNAs) and at the protein level, they are not widely used in population screening. Combining nucleic acid-based and protein-based tests could improve the overall specificity for discriminating CIN2+ lesions that carry a low risk of progressing to cervical cancer within the screening interval from those that carry an elevated risk. The challenge is to reduce unnecessary referrals without an undesired increase in false-negative diagnoses resulting in cases of cervical cancer that could have been prevented. A further challenge is to develop tests for low-and middle-income countries, which is critical to reduce the worldwide burden of cervical cancer.

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Anti-fouling SERS-based immunosensor for point-of-care detection of the B7–H6 tumor biomarker in cervical cancer patient serum

Cited by 49 publications

References 48 publications

Towards practical and sustainable SERS: a review of recent developments in the construction of multifunctional enhancing substrates

Towards practical and sustainable SERS: a review of recent developments in the construction of multifunctional enhancing substrates

Graphene for Biosensing Applications in Point-of-Care Testing

Molecular markers for cervical cancer screening

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