Anti-gastric Actions of Eugenol and Cinnamic Acid Isolated from Cinnamomi Ramulus

Jung, Joohee; Lee, Je-Hyuk; Bae, Ki Hwan; Jeong, Choon Sik

doi:10.1248/yakushi.131.1103

Cited by 39 publications

(29 citation statements)

References 24 publications

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“…Among these, eugenol, gallic acid and ellagic acid, which are abundant constituents of SAWE, have antigastric effects and antioxidant activities (32)(33)(34). Based on the previous studies, the present study hypothesized that SAWE, which contains these bioactive components, has a preventive effect against gastric injury.…”

Section: Discussionmentioning

confidence: 80%

Syzygium aromaticum water extract attenuates ethanol-induced gastric injury through antioxidant effects in rats

Jin

Lee

Shin

et al. 2016

Molecular Medicine Reports

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Abstract. The aim of the present study was to investigate whether Syzygium aromaticum water extract (SAWE) has a protective effect against ethanol-induced gastric injury in rats. Acute gastric injury was induced via intragastric administration of absolute ethanol at a dose of 5 ml/kg. SAWE (250 or 500 mg/kg/day) or cimetidine (100 mg/kg/day), which was used as a positive control, were administered to the rats 2 h prior to ethanol administration for 3 days. All rats were sacrificed 24 h following the final ethanol administration. To examine whether SAWE has a gastroprotective effect, assays were performed to assess the contents of malondialdehyde (MDA) and glutathione (GSH), the activities of catalase, glutathione-S-transferase and superoxide dismutase, and an immune-linked immunosorbent assay was performed for prostaglandin E 2 (PGE 2 ) production in gastric tissues by hematoxylin and eosin and periodic acid-Schiff staining. Histological assessment of the gastric wall was performed. Compared with ethanol treatment alone, treatment with SAWE at a dose of 250 mg/kg/day significantly decreased the gastric MDA content and increased the GSH content, catalase activity, and production of gastric PGE 2 . Histological assessment showed that SAWE attenuated inflammatory cell infiltration and the loss of epithelial cells. These findings suggested that SAWE protected against ethanol-induced gastric mucosal injury in the rats. These effects appeared to be associated with antioxidant activity, activation of the production of PGE 2 , suppression of inflammatory cell infiltration and loss of epithelial cells in the gastric mucosa. Collectively, SAWE may be beneficial in the prevention of gastric disease associated to oxidative stress.

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Section: Discussionmentioning

confidence: 80%

Syzygium aromaticum water extract attenuates ethanol-induced gastric injury through antioxidant effects in rats

Jin

Lee

Shin

et al. 2016

Molecular Medicine Reports

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“…16) Ascorbic acid was used as a positive control. Anti-H. pylori Activity H. pylori strain (ATCC 43504) was obtained from ATCC (Rockville, MD, U.S.A.).…”

Section: Preparation Of Plant Extractmentioning

confidence: 99%

“…16) Thirty minutes after treatment, 1 mL of HCl-ethanol solution was administered orally for the induction of gastric lesions. After 1 h of fasting, each animal was sacrificed and the stomach was isolated.…”

Section: Preparation Of Plant Extractmentioning

confidence: 99%

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Anti-<i>Helicobacter pylori</i> and Antiulcerogenic Activities of the Root Cortex of <i>Paeonia suffruticosa</i>

Jung

Bae

Jeong

2013

Biological & Pharmaceutical Bulletin

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In this study, we evaluated the gastric protective activities of mokdanpi in vitro. Further, we used experimental ulcer models to identify the active ingredients of mokdanpi. As a preliminary evaluation of mokdanpi ethanolic extract and its ingredients, we assessed its radical scavenging activities. In addition, its antimicrobial activity against Helicobacter pylori (H. pylori) was investigated. The antiulcerogenic activity of the active ingredients was evaluated in pylorus-ligated rats, an HCl/ethanol-induced and an absolute ethanol-induced ulcer model. We confirmed the scavenging effect of the ethanolic extract of mokdanpi and its ingredients against 2,2-diphenyl-1-picrylhydrazyl, nitric oxide and superoxide radicals, and we demonstrated that mokdanpi could inhibit the colonization of H. pylori. In an HCl-ethanol-induced ulcer model, gallic acid and catechin (100 mg/kg) inhibited 40.6% and 41.7% of gastric lesions, respectively. Catechin (100 mg/kg) significantly reduced (p<0.05) the gastric secretion induced by pylorus ligature in rats in comparison to the control group. Gallic acid (100 mg/kg) significantly increased (p<0.05) the mucus contents in an ethanol-induced ulcer model. The antioxidant ingredients (catechin and gallic acid) present in mokdanpi play a major role in antiulcerogenic activity, and demonstrate novel activity against H. pylori. Key words Paeonia suffruticosa; Helicobactor pylori; gastric ulcer; gastric cancer; catechin; gallic acidA large portion of the world's population is afflicted with gastric diseases, such as gastric ulcer, gastritis, and gastric cancer. These diseases are induced by stress, smoking, infection by Helicobacter pylori (H. pylori), and nutritional deficiencies.1) Gastric ulcers result from an imbalance between aggressive factors (i.e., gastric acid, pepsin, stimulation of the vagus nerves, secretion of gastrin, and an increased number of parietal cells) and protective factors (i.e., bicarbonate ion, mucus productivity, mucus secretion, and prostaglandins). 2)In particular, frequent gastritis or gastric ulcer is chronic and leads to death. Another important risk factor is infection from H. pylori. Since reports indicate that H. pylori-induced gastritis leads to gastric cancer, the control of H. pylori in the stomach has become a target of treatment for gastric diseases. The antibodies for H. pylori are higher in patients with gastric cancer than in control groups.3) For eradication of H. pylori, a combination therapy with a proton pump inhibitor (PPI) or bismuth and antibiotics has been used. Nevertheless, the infection rate remains high and new therapeutic alternatives are needed because of antimicrobial resistance. In this regard, plant-derived extracts have been considered in the development of antiulcerogenic drugs.Mokdanpi, the root cortex of Paeonia suffruticosa ANDREWS (Panunculaceae), is an important crude drug with analgesic, sedative, and anti-inflammatory activities, and has been used as a remedy for cardiovascular extravasated blood and female genital diseas...

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“…In recent years, several studies have reported that CR has various pharmacological activities such as vasodilatory (Kang & Shin, 2012), anti-inflammatory (Hwang et al, 2009), gastroprotective (Jung et al, 2011), anti-T2D (Suppapitipoen et al, 2006), and antioxidation (Dugoua et al, 2007;Lakshmi et al, 2009) effects. However, the mechanism of its antidiabetic activities has remained unclear.…”

Section: Introductionmentioning

confidence: 99%

The extract ofCinnamomum cassiatwigs inhibits adipocyte differentiation via activation of the insulin signaling pathway in 3T3-L1 preadipocytes

Han

Jung

Bae

et al. 2013

Pharmaceutical Biology

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Context: Obesity is associated with a number of diseases with metabolic abnormalities such as type 2 diabetes (T2D). Medicinal plants have been widely used for the treatment of obesity and related complications. Objective: In this study, we investigated the antidiabetic properties of the extract of twigs of Cinnamomum cassia Blume (Lauraceae) (Cinnamomi Ramulus; CR) in 3T3-L1 murine preadipocytes. Materials and methods: 3T3-L1 cells were differentiated into adipocytes for 3 d in insulinconditioned medium and then treated with CR extract at concentrations of 100 and 500 mg/mL for 6 d. Adipocyte differentiation was measured by Oil Red O staining, and the expression of master transcription factors, peroxisome proliferator-activated receptor-gamma (PPARg), CCAAT/enhancer binding protein-alpha (C/EBPa), and sterol regulatory element binding protein-1c (SREBP-1c), and lipid metabolism factors were investigated by reverse transcriptionpolymerase chain reaction (RT-PCR). The activation of the AMP-activated protein kinase (AMPK)/ insulin signaling pathway was assessed by western blot analysis. Results: CR extract significantly reduced lipid accumulation and down-regulated the expression of PPARg, C/EBPa, and SREBP-1c in 3T3-L1 adipocytes. CR extract also suppressed the expression of fatty acid synthase (FAS), acyl-CoA synthase, and perilipin. Moreover, CR extract markedly up-regulated the phosphorylation of AMPK and acetyl-CoA carboxylase (ACC). In addition, CR extract effectively increased the expression levels of glucose transporter-4 (GLUT-4), phosphatidylinositol 3-kinase (PI3K), and insulin receptor substrate-1 (IRS-1) in 3T3-L1 adipocytes. Discussion and conclusion: These results suggest that CR extract may have therapeutic potential as a natural agent for the improvement of T2D via regulation of the insulin-dependent signaling pathway. Keywords3T3-L1 Adipocyte, Cinnamomi Ramulus, lipid metabolism, type 2 diabetes History

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Anti-gastric Actions of Eugenol and Cinnamic Acid Isolated from Cinnamomi Ramulus

Cited by 39 publications

References 24 publications

Syzygium aromaticum water extract attenuates ethanol-induced gastric injury through antioxidant effects in rats

Syzygium aromaticum water extract attenuates ethanol-induced gastric injury through antioxidant effects in rats

Anti-<i>Helicobacter pylori</i> and Antiulcerogenic Activities of the Root Cortex of <i>Paeonia suffruticosa</i>

The extract ofCinnamomum cassiatwigs inhibits adipocyte differentiation via activation of the insulin signaling pathway in 3T3-L1 preadipocytes

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