Anti-gout and Urate-lowering Potentials of Curcumin: A Review from
Bench to Beside

Samarghandian, Saeed; Jafari-Nozad, Amir Masoud; Jafari, Amirsajad; Yousefi, Saman; Bakhshi, Hasan; Farkhondeh, Tahereh

doi:10.2174/0929867331666230721154653

Cited by 4 publications

(1 citation statement)

References 134 publications

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“…137,140 As reported that GA was the most commonly associated with the acute stage of gout and was the most common presenting symptom of gout causing inflammatory symptoms. 141,142 Also, the chronic tophaceous gout stage is the most advanced stage of the disease and is characterized by the presence of tophi, which are deposits of urate crystals in the soft tissues with the less severe inflammation compared to the early stage. 139 It is implied that there must be some physiological and pathological activity that acts as a regulator of inflammation.…”

Section: Regulatory Role Of Nets In Ga Inflammationmentioning

confidence: 99%

Targeting Neutrophil Extracellular Traps in Gouty Arthritis: Insights into Pathogenesis and Therapeutic Potential

Li,

Wu,

et al. 2024

JIR

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Gouty arthritis (GA) is an immune-mediated disorder characterized by severe inflammation due to the deposition of monosodium urate (MSU) crystals in the joints. The pathophysiological mechanisms of GA are not yet fully understood, and therefore, the identification of effective therapeutic targets is of paramount importance. Neutrophil extracellular traps (NETs), an intricate structure of DNA scaffold, encompassing myeloperoxidase, histones, and elastases -have gained significant attention as a prospective therapeutic target for gouty arthritis, due to their innate antimicrobial and immunomodulatory properties. Hence, exploring the therapeutic potential of NETs in gouty arthritis remains an enticing avenue for further investigation. During the process of gouty arthritis, the formation of NETs triggers the release of inflammatory cytokines, thereby contributing to the inflammatory response, while MSU crystals and cytokines are sequestered and degraded by the aggregation of NETs. Here, we provide a concise summary of the inflammatory processes underlying the initiation and resolution of gouty arthritis mediated by NETs. Furthermore, this review presents an overview of the current pharmacological approaches for treating gouty arthritis and summarizes the potential of natural and synthetic product-based inhibitors that target NET formation as novel therapeutic options, alongside elucidating the intrinsic challenges of these inhibitors in NETs research. Lastly, the limitations of HL-60 cell as a suitable substitute of neutrophils in NETs research are summarized and discussed. Series of recommendations are provided, strategically oriented towards guiding future investigations to effectively address these concerns. These findings will contribute to an enhanced comprehension of the interplay between NETs and GA, facilitating the proposition of innovative therapeutic strategies and novel approaches for the management of GA.

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Section: Regulatory Role Of Nets In Ga Inflammationmentioning

confidence: 99%

Targeting Neutrophil Extracellular Traps in Gouty Arthritis: Insights into Pathogenesis and Therapeutic Potential

Li,

Wu,

et al. 2024

JIR

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Anthocyanin-Rich Dark-Colored Berries: A bibliometric analysis and review of Natural Ally in Combating Glucolipid Metabolic Disorders

He,

Tang,

Peng

et al. 2024

Nutrition

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Biologically active additives in gout: opportunities and perspectives

Shelyabina,

Eliseev

2024

Medicinskij alfavit

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In recent years, there has been a growing interest in the use of biologically active additives (BAA) in the comprehensive management of gout, thereby opening new avenues for both patients and healthcare providers. Gout, as a metabolic disorder, necessitates not only traditional pharmacological interventions but also additional strategies for managing serum uric acid (SUA) levels. BAAs may serve as an important adjunct to existing medical therapies, enabling the reduction of hyperuricemia, the frequency of arthritis flare-ups, and the improvement of patients' quality of life. Research indicates that components of BAAs can modulate inflammatory responses and exhibit diuretic effects, which is particularly relevant for patients with urate nephropathy. However, despite promising results, further clinical trials are required to confirm their safety and efficacy. It is important to note that the integration of BAAs into standard therapy necessitates a careful analysis of interactions with other medications. We are on the brink of a new era in gout treatment, and BAAs may occupy a significant position in this transformation.

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Anti-gout and Urate-lowering Potentials of Curcumin: A Review from Bench to Beside

Cited by 4 publications

References 134 publications

Targeting Neutrophil Extracellular Traps in Gouty Arthritis: Insights into Pathogenesis and Therapeutic Potential

Targeting Neutrophil Extracellular Traps in Gouty Arthritis: Insights into Pathogenesis and Therapeutic Potential

Anthocyanin-Rich Dark-Colored Berries: A bibliometric analysis and review of Natural Ally in Combating Glucolipid Metabolic Disorders

Biologically active additives in gout: opportunities and perspectives

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