Anti-H1N1 virus, cytotoxic and Nrf2 activation activities of chemical constituents from Scutellaria baicalensis

Ji, Shuai; Li, Ru; Wang, Qi; Miao, Wenjuan; Li, Ziwei; Si, Longlong; Qiao, Xue; Yu, Siwang; Zhou, Demin; Ye, Min

doi:10.1016/j.jep.2015.11.018

Cited by 96 publications

(59 citation statements)

References 28 publications

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“…Additionally, in one report of 2015, a total of 30 compounds were isolated and identified from Scutellaria baicalensis, and five of them including baicalin, baicalein, wogonin, chrysin and oroxylin A showed significant anti-H1N1 activity with IC 50 values of 7.4, 7.5, 2.1, 7.7 and 12.8 lm, respectively. [72] It was worth mentioning that the cytotoxic activity was the strongest at 10 lm, and at this time, the inhibition rate was as high as 61.2%.…”

Section: Antibacterial and Antiviral Effectsmentioning

confidence: 87%

Scutellaria baicalensis Georgi. (Lamiaceae): a review of its traditional uses, botany, phytochemistry, pharmacology and toxicology

Zhao

Tang

Xie

et al. 2019

Journal of Pharmacy and Pharmacology

337

188

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Objectives Scutellaria baicalensis Georgi. (Lamiaceae) is a plant of the genus Lamiaceae, and its root is the main part used as a medicine. In China, Scutellaria baicalensis is still an important traditional Chinese medicine with the functions of clearing away heat and dampness, purging fire and detoxification. This medicinal plant is widely distributed in China, Russia, Mongolia, North Korea and Japan. The purpose of this paper was to provide a systematic and comprehensive overview on the traditional usages, botany, phytochemistry, pharmacology, pharmacokinetics and toxicology of this plant. Furthermore, the possible development trends and perspectives for future research on this medicinal plant are also discussed. Key findings So far, over 40 compounds have been isolated and identified from Scutellaria baicalensis, including flavonoids, terpenoids, volatile oils and polysaccharides. The compounds and extracts isolated from Scutellaria baicalensis exhibit a wide range of pharmacological activities, including the effects on the nervous system, effects on the immune system, liver protection, antitumour effects, antibacterial and antiviral effects, antioxidant effects and other pharmacological effects. Summary As a traditional Chinese herbal medicine, Scutellaria baicalensis has shown significant effects on the treatment of various diseases, especially hepatitis, diarrhoea, vomiting and high blood pressure. Numerous traditional uses of Scutellaria baicalensis have been confirmed by current investigations. However, it is also necessary to further study the drug-forming properties and pharmacokinetics of the active constituents of Scutellaria baicalensis, as well as to establish quality control standards for different areas of Scutellaria baicalensis, and to carry out the research at the cellular and molecular levels. Preparation nameMain compositions Traditional and clinical usages Ref.Inducing sweat to dispel heat, soothing liver and harmonizing stomach and treating hypochondriac pain, liver and treating stomach disharmony, influenza and acute upper respiratory tract infection [12] Clearing the heat and transforming phlegm, calming the liver and tranquilization and treating vertigo, liver fire flaming, insomnia and hypertension [12]

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Section: Antibacterial and Antiviral Effectsmentioning

confidence: 87%

Scutellaria baicalensis Georgi. (Lamiaceae): a review of its traditional uses, botany, phytochemistry, pharmacology and toxicology

Zhao

Tang

Xie

et al. 2019

Journal of Pharmacy and Pharmacology

337

188

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“…As a whole, aglycone forms, especially baicalein, exhibit high antioxidant activity . Moreover, their antiviral activity and, more importantly, antitumor activity has also been studied. Major flavones of the skullcap roots not only suppress the growth of the tumor cells themselves, but enhance the antitumor activity of other medications at the combined administration …”

Section: Introductionmentioning

confidence: 99%

The Relationship Between Endogenous β‐Glucuronidase Activity and Biologically Active Flavones‐Aglycone Contents in Hairy Roots of Baikal Skullcap

Dikaya

Solovyeva

Sidorov

et al. 2018

Chemistry & Biodiversity

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Here, we examine the relationship between contents of principal flavones in hairy roots of Scutellaria baicalensis with the activity of the β-glucuronidase (sGUS) enzyme during a culturing cycle. Using RP-HPLC, we show that the highest contents of aglycones, baicalin and wogonin is observed at the growth days 8, 14, and 71 and reach 45, 41, and 62% (based on the total weight of hairy roots of the Baikal skullcap), correspondingly. Their accumulation is accompanied by increase of the sGUS activity, which we determined fluorometrically. Moreover, the enzyme activity is characterized by significant and reasonable correlation only with the wogonin contents. Our results confirm a significant role of sGUS at the final steps of the metabolism in root-specific flavones of Baikal skullcap and suggest how one can optimize the conditions of culturing the hairy roots for biotechnological production of individual flavonoids. For example, at the culturing day 71 wogonin constituted over 80% of all flavones extracted from cells.

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“…The compounds 1, 34, 54, and 55 were chemically synthesized according to the reported method [25] by Hangzhou Yuhao Chemical Technology Co., Ltd . [26] Substrates 3-10, 13, 17, 18, 20, 22, 24-33, 36-38, 44-53, 56, 57, 59-64, 66-68 [26] Substrates 3-10, 13, 17, 18, 20, 22, 24-33, 36-38, 44-53, 56, 57, 59-64, 66-68 …”

Section: Experimental Section Materialsmentioning

confidence: 99%

“…Compounds 2, 11, 12, 14-16, 19, 21, 23, 35, 39-43, 58, 65, and 69 were isolated from Glycyrrhiza uralensis, G. inflata, G. glabra, and Scutellaria baicalensis in our laboratory. [26] Substrates 3-10, 13, 17, 18, 20, 22, 24-33, 36-38, 44-53, 56, 57, 59-64, 66-68, 70-96 were individually purchased from Shanghai YuanYe Biotechnology Co., Ltd. (Shanghai, China), Beijing Solarbio Science & Technology Co., Ltd (Beijing, China), Chengdu Must Bio-Technology Co., Ltd (Chengdu, China), and TargetMol (Shanghai, China). The prenyl donors, dimethylallyl diphosphate (DMAPP), geranyl diphosphate (GPP), farnesyl diphosphate (FPP), geranylgeranyl diphosphate (GGPP), and phytyl diphosphate (PPP), were chemically synthesized according to the literature.…”

Section: Experimental Section Materialsmentioning

confidence: 99%

Enzymatic O‐Prenylation of Diverse Phenolic Compounds by a Permissive O‐Prenyltransferase from the Medicinal Mushroom Antrodia camphorata

Dong

et al. 2019

Adv Synth Catal

Self Cite

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Prenylated compounds are pharmacologically attractive natural products that are widely distributed in nature. Prenyltransferases (PTs) could catalyze the transfer of prenyl moieties to aromatic acceptors and increase the structural diversity and biological activity of natural products. In this work, a permissive O-prenyltransferase AcaPT was discovered from Antrodia camphorata, a precious medicinal mushroom in Taiwan. AcaPT exhibited robust O-prenylation capability toward structurally diverse drug-like phenolic compounds, including antrodins, flavonoids, and coumarins. In total, 23 Oprenylated products were obtained by scaled-up enzymatic synthesis. AcaPT could be used as an efficient biocatalyst to synthesize O-prenylated derivatives for drug discovery.

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Anti-H1N1 virus, cytotoxic and Nrf2 activation activities of chemical constituents from Scutellaria baicalensis

Cited by 96 publications

References 28 publications

Scutellaria baicalensis Georgi. (Lamiaceae): a review of its traditional uses, botany, phytochemistry, pharmacology and toxicology

Scutellaria baicalensis Georgi. (Lamiaceae): a review of its traditional uses, botany, phytochemistry, pharmacology and toxicology

The Relationship Between Endogenous β‐Glucuronidase Activity and Biologically Active Flavones‐Aglycone Contents in Hairy Roots of Baikal Skullcap

Enzymatic O‐Prenylation of Diverse Phenolic Compounds by a Permissive O‐Prenyltransferase from the Medicinal Mushroom Antrodia camphorata

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