Anti-hemorrhagic activity of ethanol extract of Moringa oleifera leaf on envenomed albino rats

Adeyemi, Sodiq; Larayetan, Rotimi; Onoja, AO; Ajayi, Abayomi; Yahaya, Abdulrazaq; Ogunmola, Oluranti O.; Adeyi, Akindele Oluwatosin; Olisah, Chijioke

doi:10.1016/j.sciaf.2021.e00742

Cited by 12 publications

(15 citation statements)

References 19 publications

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“…By using UPLC-Q-TOF-MS (ultra-high performance liquid chromatography with quadrupole time-of-flight mass spectrometry), phenolic acid derivatives were identified, which included glucomoringin, 3-caffeoyl quinic acid, 3-p-coumaroylquinic acid, 4-caffeoyl quinic acid, acetyl 4-(a-L-rhamnopyranosyloxy) benzyl glucosinolate, apigenin C-diglycoside, 4-p-coumaroylquinic acid, 4-feruloylquinic acid, quercetin-3-O-rutinoside, apigenin-C-hexose, quercetin-7-hexose, quercetin-3-hexose, quercetin-3-acetyl-hexose, kaempferol-3-O-rutinoside, luteolin-7-O-glucoside, kaempferol-3-hexose, cyanidin hexose isorhamnetin-hexose, kaempferol acetyl hex-ose (Teclegeorgish et al 2021), rutin, kaempferol acetyl glycoside, quercetin-3-glucoside, quercetin-3-acetylglucoside and kaempferol 3-glucoside were identified by LC-ESI-MS (liquid chromatography electrospray ionization tandem mass spectrometry) as reported by Hamed et al (2019). The results of the identification of phytochemical compounds from the ethanol extract of moringa leaves with GC MS (gas chromatography-mass spectrometry) showed the presence of 9, 12, 15-octadecatrienoic acid (39.66%), hexadecenoic acid (16.71%), palmitic acid, ethyl ester (14.70%), and phytol (9.81%) as the largest component (Adeyemi et al 2021). Their phenolic compounds in M. oleifera leaves and their health benefits are shown in Table 2.…”

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confidence: 73%

“…The moringa tree trunk methanol extract showed the ability to repair glycerol-induced rat kidney damage (Apedapo et al 2020). The ethanol extract of moringa leaves shows the ability to inhibit neurotoxins from venom so that it acts as an antivenom and prevents bleeding (Adeyemi et al 2021). Moringa leaf bioactive compounds improve physical and metabolic functioning related to muscles, they act as antitumor and cytotoxic (García-Beltrán et al 2020), antiasthma, anticancer, anti-inflammatory, hepatoprotective, and cardioprotective agents (Hassan et al 2021).…”

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confidence: 99%

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Potential of moringa (Moringa oleifera) leaf powder for functional food ingredients: A review

Ariani¹,

Estiasih²,

Sunarharum³

et al. 2023

Czech J. Food Sci.

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One of the efforts to produce functional foods is using ingredients containing health-beneficial bioactive compounds. Another way to produce functional foods is fermentation generating bioactive compounds or fortification with the bioactive compound extract. An ingredient historically believed to have benefits on health is moringa (Moringa oleifera) leaf powder. Moringa leaf powder is a valuable source of functional ingredients, including protein, vitamins, minerals, and phytonutrients such as carotenoids, tocopherols, polyphenols, flavonoids, alkaloids, and tannins. However, moringa is a plant that is distributed in various tropical countries in the world. Its quality depends on geographical differences, cultivars, environmental conditions, seasons, genotypes, and varieties. This article reviews the bioactive compounds of moringa leaf powder and the characteristics of moringa leaf powder extract. The effect of moringa leaf powder fortification on food product characteristics is also discussed. Moringa leaf powder possesses many pharmacological properties, such as anticancer, anti-inflammatory, hepatoprotective, cardioprotective, and antioxidant ones. The bioactivity of leaf extract is extracting solvent dependent. Therefore, fortification results in nutritional improvement and increasing health benefits of food products. However, the adverse effect is found in sensory. Thus properties, thus the moringa leaf powder fortification level usually is less than 10%. Changes in the functional properties of foods due to moringa leaf powder fortification have been studied to a limited extent. A low level of fortification might not affect the properties of food products. Therefore, moringa leaf powder is potentially used as a functional food ingredient. Some studies reported the toxicological effects of moringa leaf powder and the use of this ingredient, should be below the harmful doses.

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confidence: 73%

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confidence: 99%

Potential of moringa (Moringa oleifera) leaf powder for functional food ingredients: A review

Ariani¹,

Estiasih²,

Sunarharum³

et al. 2023

Czech J. Food Sci.

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“…Furthermore, compound 46 also inhibited α-glucosidase and pancreatic lipase with IC 50 values of 40 and 35 µg/mL, respectively. Compound 47 also exhibited antiviral properties against virus H1N1 with an IC 50 value of 3.42 µg/mL [ 13 , 24 , 25 , 26 , 27 , 33 , 39 , 42 , 43 , 44 , 45 , 46 ].…”

Section: Phytochemical Constituentmentioning

confidence: 99%

“…In addition to their enzyme inhibitory effects, compounds 109 and 110 showcased strong antioxidant properties, as indicated by DPPH IC 50 values of 0.475 and 0.671 mg/mL, respectively. Furthermore, compound 122 exhibited significant antibacterial activity, with MIC values of 32 µg/mL against pathogens such as S. dysenteriae , S. boydii , and S. aureus [ 13 , 25 , 30 , 37 , 41 , 43 , 51 , 58 , 63 , 64 , 65 , 66 , 67 , 68 , 69 ].…”

Section: Phytochemical Constituentmentioning

confidence: 99%

Moringa oleifera: A Review of the Pharmacology, Chemical Constituents, and Application for Dental Health

Amin,

Ariwibowo,

Putri

et al. 2024

Pharmaceuticals

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Moringa oleifera L., commonly known as Kelor in Indonesia and miracle tree in English, has a rich history of utilization for medicinal, nutritional, and water treatment purposes dating back to ancient times. The plant is renowned for its abundance of vitamins, minerals, and various chemical constituents, making it a valuable resource. Among its notable pharmacological properties are its effectiveness as an anti-diabetic, anti-diarrheal, anti-helmintic, anti-leishmanial, anti-fungal, anti-bacterial, anti-allergic, anti-cancer, anti-inflammatory, and anti-oxidant agent. In this comprehensive review, we delve into the extensive pharmacological applications and phytochemical constituents of M. oleifera and its application in dental health.

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“…The identity of each compound's mass fragmentation patterns and computed retention durations were validated and compared to those in databases. 34,41 Free radical scavenging (In vitro Assay) DPPH assay D. tripatela extracts were tested for antioxidant properties and radical scavenging potential against the free radical DPPH. For around 40 minutes at room temperature in the dark, five different doses (25-125 µgmL -1 ) of D. tripatela extracts and synthetic antioxidant Vitamin C were incubated with a DMSO solution of DPPH.…”

Section: Gc-ms Analysismentioning

confidence: 99%

Chemical Elucidation, Microbial Growth and Free Radical Inhibitory Effects of Dennettia tripetala Fruit: In vitro and In vivo Model Experiments

2023

TJNPR

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Natural products are being exploited in the treatment of diverse ailments stemming from microbial and free radical incursion in the African native societies. The current study was designed to elucidate the bioactive constituents, microbial growth and free radical inhibitory effects of Dennettia tripetalafruit, employing in vitro and in vivo models. Briefly, phytochemical analysis was qualitatively investigated. The free radical scavenging assays using 2,2-diphenyl-1- picrylhdrazyl (DPPH) and 2,2’-azino-bis (3-ethylenzoline-6-sulfonic acid (ABTS) radical solutions using vitamin C as reference antioxidant. Antibacterial activity was carried out using agar diffusion well. Bioactive elucidation was conducted using Gas chromatography Mass Spectroscopy (GC-MS). Liver protective effect of the extract was investigated on rats’ model. Phytochemical analysis of the crude extracts (hexane and ethanol) revealed saponins, tannin, flavonoid, steroids, phenols and terpenoids. GC-MS analysis revealed various bioactive compounds. DPPH inhibitory effect of the hexane and ethanol extracts, displayed IC50 values, 3.86 and 4.01 µg/mL against a corresponding vitamin C (IC50 value, 0.007 µg/mL). Both extracts solution scavenged ABTS radical (IC50 values, 4.53 and 4.79 µg/mL) against vitamin C (IC50 values, 0.005 µg/mL). The extracts demonstrated promising antibacterial activities against eight selected multidrug-resistant strains, comprising Gram positive and negative strains. The crude extract protects liver induced carbontetrachloride toxic onslaught through significant (p <0.05) increased in the catalase, superoxide dismutase activities, reduced glutathione and depleted malonedialdehyde levels in the rats’ liver co-treatment groups. Overall, the findings suggest D. tripetela’s leaf extract a promising antidote for the treatment of free radical and microbial , infectious diseases.

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Anti-hemorrhagic activity of ethanol extract of Moringa oleifera leaf on envenomed albino rats

Cited by 12 publications

References 19 publications

Potential of moringa (Moringa oleifera) leaf powder for functional food ingredients: A review

Potential of moringa (Moringa oleifera) leaf powder for functional food ingredients: A review

Moringa oleifera: A Review of the Pharmacology, Chemical Constituents, and Application for Dental Health

Chemical Elucidation, Microbial Growth and Free Radical Inhibitory Effects of Dennettia tripetala Fruit: In vitro and In vivo Model Experiments

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