Anti-hemorrhoidal potential of standardized leaf extract of Dolichandrone falcata

Dhaswadikar, Suhas R.; Parmar, Komal M.; Kamble, Shantibhushan K.; Kathuria, Ishita; Dhobi, Mahaveer; Birajdar, Arunadevi; Prasad, Shilpa; Itankar, Prakash R.

doi:10.1016/j.phyplu.2021.100172

Cited by 14 publications

(10 citation statements)

References 27 publications

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“…This active constituent from croton oil enables the release of inflammatory mediators like prostaglandins, leukotrienes, bradykinins, nitric oxide, chemokines, and cytokines, which accelerate inflammation. These factors together trigger the regulation of endothelial cells, mast cells, fibroblasts, and macrophages, along with newly assigned inflammatory cells like eosinophils, neutrophils, lymphocytes, and monocytes that contribute to severe inflammation (Azeemuddin et al, 2014; Dhaswadikar et al, 2022). In our study also, application of COP caused severe inflammation and significantly increased macroscopic severity scores and the RAC in negative control as compared to normal control, which confirmed the induction of hemorrhoids, complying with the earlier research findings (Azeemuddin et al, 2014; Dey et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

“…The results of preliminary phytochemical screening confirmed the availability of phenols, alkaloids, tannins, and flavonoids as major components in EBL. These phytoconstituents have been well reported to have anti-inflammatory and antioxidant activity (Dhaswadikar et al, 2022; Sengar et al, 2015; Yang et al, 2013), which directly or indirectly contributed to the anti-hemorrhoidal potential of EBL. Furthermore, EBL was standardized with the help of HPLC using quercetin as a marker.…”

Section: Discussionmentioning

confidence: 99%

“…The therapies available for treating hemorrhoidal disease involve laser treatment, cryotherapy, hemorrhoidectomy, sclerotherapy, bipolar diathermy, and infrared photocoagulation, which are associated with numerous side effects. Therefore, there is a need to assess medicinal plants for their anti-hemorrhoid potential, as plants are considered relatively safe as compared to conventional drugs (Dhaswadikar et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

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Optimization of Extraction Process and Anti-Hemorrhoidal Activity of Blumea lacera (Burm.f.) DC. Leaves in Croton Oil-induced Hemorrhoid Model

Dubey

Bhanukiran

Prasad

et al. 2023

Pharmacognosy Magazine

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Background and objective Blumea lacera (Burm.f.) DC. (Family—Asteraceae) is widely used for treating hemorrhoids by several ethnomedicinal practitioners and tribes in India. Thus, the main objective of the present investigation was to evaluate the potential of B. lacera leaf extract in the treatment of hemorrhoids using a croton oil-induced hemorrhoid rat model. Materials and Methods Ethanol extract of B. lacera (EBL) leaves was prepared using Soxhlet extraction, optimized using Box–Behnken design (BBD), and quantified using high-pressure liquid chromatography (HPLC). Furthermore, the vasoactive ions were estimated using ion-exchange chromatography. Hemorrhoids were induced in the recto-anal portion of experimental rats, followed by treatment with EBL (100, 200, and 400 mg/kg; par oral (p.o.)) and Pilex granules as a standard anti-hemorrhoid drug for 7 days. The anti-hemorrhoid potential was evaluated on the eighth day by assessing the severity of hemorrhoids, biochemical parameters, and histology of recto-anal tissue. Results Upon treatment with EBL and Pilex, there was a significant ( p < 0.05) reduction in the inflammatory severity index, concentration of Evans blue dye, recto-anal coefficient (RAC), elevated cytokines level, and restoration of altered antioxidant status. Furthermore, the histopathological results revealed a marked reduction in the inflammatory zones along with minimally dilated blood vessels. Conclusion The present study confirmed the traditional claims of the plant B. lacera in the treatment of hemorrhoids, which may be attributed to its anti-inflammatory and antioxidant potential in EBL, where quercetin could be considered the main contributor.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Optimization of Extraction Process and Anti-Hemorrhoidal Activity of Blumea lacera (Burm.f.) DC. Leaves in Croton Oil-induced Hemorrhoid Model

Dubey

Bhanukiran

Prasad

et al. 2023

Pharmacognosy Magazine

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“…Table 1 Tannic acid found numerous positive effects toward human health. Ethanolic extract of D. falcata leaves in which comprised of tannin as much as 55.77 ± 1.55 mg/g, equivalent to tannic acid, shows a positive effect in haemorrhoids treatment [21]. Combination of aluminum potassium sulfate and TA also applied for internal hemorrhoids treatment [22].…”

Section: Sources and Its Isolation Sources And Its Isolation Sources ...mentioning

confidence: 99%

Review on Tannic Acid: Potensial Sources, Isolation Methods, Aplication and Bibliometric Analysis

Hartati¹,

Paramita

2022

RICE

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Tannic acid is the simplest form of astringent hydrolysable tannin in which naturally occurring in practically all aerial plant tissues and regarded as the most famous tanning material. Tannic acid having various types of pharmacological activities including anti-viral, anti-cancer, anti-oxidant, anti-microbial, anti-helminthic, anti- haemorrhoids, and anti-diarrhea. Tannic acid can be isolated from various parts of herbaceous and woody plants via different methods such as maceration, soxhletation, micro-channeling and solvent distillation. Tannic acid also found other prospective use in numerous fields such as in textile, leather, corrosion prevention and in rubber based epoxy resin. Bibliometric analysis shows research on tannic acid application trend is move towards the application of tannic in hydrogel formulations and incorporation.

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“…In traditional Ayurvedic and Unani systems, it is also used for diarrhea, stomach pain, ringworm, swelling, fever, skin, and blood diseases, etc. [6,7] The detailed description and plant profile of BS are tabulated in Table 1. These trees grow plentifully in arid hilly areas of India and produce resins, which are used for medicinal purposes, as well as irritation, bronchial asthma, hyperlipidemia, cancer, etc., Boswellic acid and other chemical constituents found in BS gum resin function as steroids and reduce blood sugar and lipid profiles in obese people.…”

Section: Introductionmentioning

confidence: 99%

In Silico Exploration of Potential Phytoconstituents from the Bark Extract of Boswellia serrata for Hemorrhoidal Disease: Molecular Docking and Molecular Dynamics Analysis**

Rao,

Maurya,

Kumar Raidas

et al. 2023

Chemistry & Biodiversity

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Boswellia serrata Roxb. Ex Colebr is a popular medicinal plant used traditionally in herbal medicinal preparations to treat a variety of diseases. The purpose of the present investigation was to investigate the anti‐hemorrhoidal property of the bark extract of B. serrata (BS). For this, the sequential Soxhlet extraction method was carried out by using different solvents such as hexane, chloroform, and methanol. After the extraction, the obtained dry extracts were tested for quantitative determinations such as total alkaloid content (TAC), total flavonoid content (TFC), total phenol content (TPC), and total tannin content (TTC) for all the extracts. Moreover, in vitro antioxidant activity was measured using 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) free radical scavenging activity and scavenging activity against 2,2′‐azino‐bis(3‐ethylbenzothiazoline‐6‐sulfonic acid (ABTS). Methanolic bark extract showed the highest TPC (67.10±1.83), TFC (372.73±4.45), TAC (9.732±1.06), and TTC (48.932±1.82), as well as the antioxidant assays DPPH (IC50=9.88 μg/ml) and ABTS (IC50=15.09 μg/ml). In this study, both LC–MS and GC–MS were performed to identify the chemical composition of all the extracts. Consequently, 19 compounds were identified by GC–MS and 27 compounds were identified by LC–MS analysis. The identified phytoconstituent(s) that could potentially interact with the target protein cyclooxygenase‐2 (COX‐2) (PDB: 4RRW) using molecular dynamics simulation and in silico docking were studied. Three compounds that have passed in drug‐likeness and ADME‐Tox properties are having more docking score than the standard. In this study, camptothecin, justicidin B, and taxiphyllin are identified as potential lead compounds with anti‐hemorrhoidal properties and may be helpful in the process of drug development and discovery of novel drugs. Hence, these results demonstrate that BS is a good source of pharmacologically active components with potential applications against hemorrhoidal disease.

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Anti-hemorrhoidal potential of standardized leaf extract of Dolichandrone falcata

Cited by 14 publications

References 27 publications

Optimization of Extraction Process and Anti-Hemorrhoidal Activity of Blumea lacera (Burm.f.) DC. Leaves in Croton Oil-induced Hemorrhoid Model

Optimization of Extraction Process and Anti-Hemorrhoidal Activity of Blumea lacera (Burm.f.) DC. Leaves in Croton Oil-induced Hemorrhoid Model

Review on Tannic Acid: Potensial Sources, Isolation Methods, Aplication and Bibliometric Analysis

In Silico Exploration of Potential Phytoconstituents from the Bark Extract of Boswellia serrata for Hemorrhoidal Disease: Molecular Docking and Molecular Dynamics Analysis**

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