Anti-Herpes Simplex virus Activities of Bioactive Extracts from <i>Antrodia Camphorata</i> Mycelia

He, Yuanchuan; Lu, Zenghui; Shi, Ping; Hao, Jingchao; Zhao, Zong-Jie; Xie, Hui; Mao, Ping; Chen, Shijiang

doi:10.3851/imp2988

Cited by 12 publications

(8 citation statements)

References 18 publications

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“…A subsequent study by the authors showed the extract elicits its effect early in the viral replication cycle by blocking HSV-2 attachment, adsorption, and entry into host cells. 191 Furthermore, He et al 39 observed an ethanolic extract of the fungus Antrodia camphorata to have antiviral activity against HSV-1 (strain F) and HSV-2 (strain G). Although not nearly as potent as acyclovir, A. camphorata was found to inhibit viral plaque formation with IC 50 values of 61.2 mg/ml and 57.5 mg/ml for HSV-1 and HSV-2, respectively.…”

Section: Asiamentioning

confidence: 99%

“…Furthermore, He et al 39 observed an ethanolic extract of the fungus Antrodia camphorata to have antiviral activity against HSV-1 (strain F) and HSV-2 (strain G). Although not nearly as potent as acyclovir, A. camphorata was found to inhibit viral plaque formation with IC 50 values of 61.2 μg/ml and 57.5 μg/ml for HSV-1 and HSV-2, respectively.…”

Section: Single Herbs In Vitromentioning

confidence: 99%

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Review of Whole Plant Extracts With Activity Against Herpes Simplex Viruses In Vitro and In Vivo

Garber

Barnard

Pickrell

2021

J Evid Based Complementary Altern Med

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Herpes simplex viruses, HSV-1 and HSV-2, are highly contagious and cause lifelong, latent infections with recurrent outbreaks of oral and/or genital lesions. No cure exists for HSV-1 or HSV-2 infections, but antiviral medications are commonly used to prevent and treat outbreaks. Resistance to antivirals has begun to emerge, placing an importance on finding new and effective therapies for prophylaxis and treatment of HSV outbreaks. Botanicals may be effective HSV therapies as the constituents they contain act through a variety of mechanisms, potentially making the development of antiviral resistance more challenging. A wide variety of plants from different regions in the world have been studied for antiviral activity against HSV-1 and/or HSV-2 and showed efficacy of varying degrees. The purpose of this review is to summarize research conducted on whole plant extracts against HSV-1 and/or HSV-2 in vitro and in vivo. The majority of the research reviewed was conducted in vitro using animal cell lines, and some studies used an animal model design. Also summarized are a limited number of human trials conducted using botanical therapies on HSV lesions.

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Section: Asiamentioning

confidence: 99%

Section: Single Herbs In Vitromentioning

confidence: 99%

Review of Whole Plant Extracts With Activity Against Herpes Simplex Viruses In Vitro and In Vivo

Garber

Barnard

Pickrell

2021

J Evid Based Complementary Altern Med

View full text Add to dashboard Cite

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“…Recently, the crude ethanol extract of Antrodia camphorate has been found to have the potential to inhibit HSV-1. Whilst fraction A and B being the major fractions in the extract, fraction A exhibited better anti-HSV-1 activity than crude extract, suppressing HSV-1 replication significantly in Vero cells after being infected with HSV-1 for 1 to 4 h [ 34 ]. Besides, the dried seeds of N. nucifera were collected and their ethanolic extracts were identified as NN-H, NN-E, and NN-B.…”

Section: Natural Anti-hsv-1 Products From Tcmmentioning

confidence: 99%

“…Other natural products inhibit HSV-1 by impairing the replication of viral genes. Fraction A in the crude ethanol extract of Antrodia camphorate significantly suppressed HSV-1 replication in Vero cells after being infected with HSV-1 for 1 to 4 h [ 34 ]. Nevertheless, further studies are required to find out the molecular mechanism and signal pathway mining of compound A against HSV-1.…”

Section: The Pharmacodynamic Mechanism Of Tcm Against Hsv-1mentioning

confidence: 99%

Traditional Chinese Medicine as a Potential Source for HSV-1 Therapy by Acting on Virus or the Susceptibility of Host

Xiao-hua

Luo

et al. 2018

IJMS

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Herpes simplex virus type 1 (HSV-1) is the most common virus, with an estimated infection rate of 60–95% among the adult population. Once infected, HSV-1 can remain latent in the host for a lifetime and be reactivated in patients with a compromised immune system. Reactivation of latent HSV-1 can also be achieved by other stimuli. Though acyclovir (ACV) is a classic drug for HSV-1 infection, ACV-resistant strains have been found in immune-compromised patients and drug toxicity has also been commonly reported. Therefore, there is an urge to search for new anti-HSV-1 agents. Natural products with potential anti-HSV-1 activity have the advantages of minimal side effects, reduced toxicity, and they exert their effect by various mechanisms. This paper will not only provide a reference for the safe dose of these agents if they are to be used in humans, referring to the interrelated data obtained from in vitro experiments, but also introduce the main pharmacodynamic mechanisms of traditional Chinese medicine (TCM) against HSV-1. Taken together, TCM functions as a potential source for HSV-1 therapy by direct (blocking viral attachment/absorption/penetration/replication) or indirect (reducing the susceptibility to HSV-1 or regulating autophagy) antiviral activities. The potential of these active components in the development of anti-HSV-1 drugs will also be described.

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“…cinnamomea. which possess anticancer and anti-inflammatory activities. − In addition, a number of benzenoids in A. cinnamomea have been reported to possess anti-inflammatory activity.…”

Section: Introductionmentioning

confidence: 99%

Current Advances on the Structure, Bioactivity, Synthesis, and Metabolic Regulation of Novel Ubiquinone Derivatives in the Edible and Medicinal Mushroom Antrodia cinnamomea

Zhang

Huang

et al. 2017

J. Agric. Food Chem.

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In recent years, Antrodia cinnamomea has attracted great attention around the world as an extremely precious edible and medicinal mushroom. Ubiquinone derivatives, which are characteristic metabolites of A. cinnamomea, have shown great bioactivities. Some of them have been regarded as promising therapeutic agents and approved into clinical trial by the U.S. Food and Drug Administration. Although some excellent reviews have been published covering different aspects of A. cinnamomea, this review brings, for the first time, complete information about the structure, bioactivity, chemical synthesis, biosynthesis, and metabolic regulation of ubiquinone derivatives in A. cinnamomea. It not only advances our knowledge on the bioactive metabolites, especially the ubiquinone derivatives, in A. cinnamomea but also provides valuable information for the investigation on other edible and medicinal mushrooms.

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Anti-Herpes Simplex virus Activities of Bioactive Extracts from Antrodia Camphorata Mycelia

Abstract: A. camphorata mycelia and antrodin A might have potential use as anti-HSV agents and are promising candidates for future antiviral drug design.

Cited by 12 publications

References 18 publications

Review of Whole Plant Extracts With Activity Against Herpes Simplex Viruses In Vitro and In Vivo

Review of Whole Plant Extracts With Activity Against Herpes Simplex Viruses In Vitro and In Vivo

Traditional Chinese Medicine as a Potential Source for HSV-1 Therapy by Acting on Virus or the Susceptibility of Host

Current Advances on the Structure, Bioactivity, Synthesis, and Metabolic Regulation of Novel Ubiquinone Derivatives in the Edible and Medicinal Mushroom Antrodia cinnamomea

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