Anti-histone antibodies in schizophrenia and affective disorders

Antinuclear antibodies and thyroid function in sexually abused girls

“…The higher incidence of dysthymia, suicidal ideation, and suicide attempts seen in the sexually abused girls studied here is interesting in light of the results of some (Maes et al, 1991;Maes et al, 1993); but not all (Villemain et al, 1988) studies reporting a higher incidence of antinuclear antibodies in adults with major depression. The significant of these autoimmune antibodies in major depression is unclear.…”

Schizophrenia, autoimmunity and immune system dysregulation: A comprehensive model updated and revisited

“…A search for antibodies against specific brain structures (''antibrain antibodies'') has also yielded important positive findings with serum antibodies found against specific brain areas implicated in schizophrenia, namely the hippocampus, septum, cingulated gyrus, amygdala and frontal cortex (reviewed in [36]). Antibodies in schizophrenia relating to nonspecific or specific autoimmune processes have also been found including anticardiolipin antibodies [64,65], antinuclear antibodies [66], anti-DNA antibodies [67] and anti-histone [68]. In a study by members of our team, we noted increased serum levels in schizophrenia of anticardiolipin, anti-asialo-GM and anti-bovine extracts by means of the ELISA technique.…”

Antibodies to native and denatured DNA in the serum of patients with schizophrenia depending on the clinical features of the disease

“…Кроме того, при шизофрении обнаружены такие воспалительные маркеры, как активация макрофагов, увеличенная экспрессия провоспалительных генов, измененное соотношение глюкокортикоидных рецепторов в моноцитах периферической крови, активация Т-хелперов 1-го типа [11]. Иммунологические нарушения при шизофрении приводят к формированию специфических АТ к антигенам головного мозга [13,14]. Общеизвестно увеличение концентрации IgG и IgA в сыворотке крови больных шизофренией по сравнению со здоровыми.…”