Anti-HIV-1 activities of extracts from the medicinal plant Rhus chinensis

Wang, Ruirui; Gu, Qiong; Yang, Liu‐Meng; Chen, Ji‐Jun; Li, Shunying; Zheng, Yong‐Tang

doi:10.1016/j.jep.2005.11.008

Cited by 46 publications

(33 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…They could provide a safer and more effective platform for newer drugs and could lead to better success than routine random screening. Botanical extracts provide a wide spectrum of biological and pharmacological properties, including cytoprotective, anti cancer, anti-inflammatory, immunomodulative and anti-infectious activities (Wang et al 2006) Many compounds with anti-HIV effects have been screened out from botanicals and found to inhibit HIV at nearly all stages of the viral life cycle.…”

Section: Discussionmentioning

confidence: 99%

Peltophorum Africanum, a Traditional South African Medicinal Plant, Contains an Anti HIV-1 Constituent, Betulinic Acid

Theo

Masebe

Suzuki

et al. 2009

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Peltophorum Africanum, a Traditional South African Medicinal Plant, Contains an Anti HIV-1 Constituent, Betulinic Acid

Theo

Masebe

Suzuki

et al. 2009

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

“…PBMCs, 2×10 5 per well, were seeded into 24-well culture plates (Nunc; Nalge Nunc International, Rochester, NY, USA) and incubated for 24 h. Then, PBMCs were treated with 350 μg/ml of eugenol and 80 μg/ml of eugenol epoxide either concurrent with HIV-1 (0 h) or at intervals of 6 and 12 h pre-infection or also post-infection. After incubation at 37°C for 72 h, the reduction in the virus titer was measured by realtime polymerase chain reaction (PCR) assay and infection cultures containing the extracts were compared with that of the control cultures for each treatment.…”

Section: Time Of Addition Studymentioning

confidence: 99%

“…Currently, many researches have been performed worldwide to isolate the active novel compounds from plants for preventing transmission of HIV and treatment of patients [3]. A diversity of secondary metabolites obtained from these products including alkaloids, polyphenols, flavonoids, sulphated polysaccharides, coumarines and triterpenes [4,5]. These compounds inhibit unique enzymes and proteins critical to the life cycle of HIV, including the reverse transcription process, virus entry, the integrase or protease [6,7].…”

Section: Introductionmentioning

confidence: 99%

Anti-HIV-1 Activities of Aerial Parts of Ocimum basilicum and its Parasite Cuscuta campestris

Behbahani¹,

Mohabatkar²,

Soltani³

2013

J Antivir Antiretrovir

View full text Add to dashboard Cite

Objectives: The present investigation was carried out to test anti-HIV-1 activity of pure compounds isolated from aerial part extracts of Ocimum basilicum and its parasite Cuscuta campestris. Materials:The anti-HIV-1 activity of these extracts was performed by use of real-time polymerase chain reaction (PCR) assay and high pure viral nucleic acid kit. Results:The most active fractions were detected by NMR as eugenol and eugenol epoxide respectively in Ocimum basilicum and Cuscuta campestris. The apparent effective concentrations for 50% plaque reduction (EC50) of eugenol and eugenol epoxide were 350 and 80 μg/ml. Time of addition studies demonstrated that the inhibitory effect of eugenol and eugenol epoxide is higher respectively in pre HIV-1 infection and during infection. Conclusion:These results demonstrate that eugenol and eugenol epoxide may prevent HIV-1 replication with two different mechanisms.

show abstract

“…They found that the major tea polyphenol (-)-epigallocatechin-3-gallate (EGCG) suppress extracellular signals and cell proliferation through epidermal growth factor receptor binding in human A431 epidermoid carcinoma cells; EGCG also blocks the induction of nitric oxide synthase by down-regulating lipopolysaccharide-induced activity of the transcription factor NFB in macrophages. A Chinese drug plant, Rhus chinesis which is used as a folk medicine in china was evaluated against HIV-1 by Wang et al (2005). They extracted the components in different solvent i.e.…”

Section: Drug Plants As a Potent Therapeutic For Some Challenging Hummentioning

confidence: 99%

A review on scientific technologies in practice to innovate plant based molecules and to improve herbal drug quality to overcome health problems

Gupta

Khandelwal

Prasad

et al. 2010

JANS

View full text Add to dashboard Cite

Medicines obtained from drug plants and other sources are commonly called traditional medicines. They have played an important role in the treatment of several human diseases since ancient times. India possessed a great wealth of traditional health care system known as Ayurveda related to the use of plant species. The global market of herbal drugs has a great potential around the world. Demand of plant based medicines is also increasing among western countries because of a general consideration that most allopathic drugs are associated with more or less side effects. Many pharmaceutical companies are now manufacturing Ayurvedic phytopharmaceutical products. However, enough efforts have not been made to get suitable substitute of modern allopathic medicines from these traditionally used drug plants and herbal drugs. This traditional system of healthcare in India still needs extensive evidence-based scientific researches in promoting its therapies. This review paper deals with modern scientific approaches to find out new plant based molecules and to develop new technologies in a continuous process and should be applied in the practice to improve the quality of herbal drugs in Indian pharmaceutical industries. Critical assessment of quality assurance including researches on pharmacognosy, chemistry, pharmacology, antimicrobial activity and clinical studies carried out on various Ayurvedic medicinal plants are also being presented.

show abstract

Anti-HIV-1 activities of extracts from the medicinal plant Rhus chinensis

Cited by 46 publications

References 14 publications

Peltophorum Africanum, a Traditional South African Medicinal Plant, Contains an Anti HIV-1 Constituent, Betulinic Acid

Peltophorum Africanum, a Traditional South African Medicinal Plant, Contains an Anti HIV-1 Constituent, Betulinic Acid

Anti-HIV-1 Activities of Aerial Parts of Ocimum basilicum and its Parasite Cuscuta campestris

A review on scientific technologies in practice to innovate plant based molecules and to improve herbal drug quality to overcome health problems

Contact Info

Product

Resources

About