Anti-HIV Active Naphthyl Analogues of HEPT and DABO

Infrared multiple photon dissociation action spectroscopy of protonated uracil and thiouracils: Effects of thioketo-substitution on gas-phase conformation

“…Similarly, 6-methyl-2-thiouracil has also been demonstrated to be an effective antithyroid drug [42]. Due to these therapeutic activities, a series of derivatives of 2-thiouracil and 4-thiouracil can also be found in many pharmacological drugs for anticancer [43], antithyroid [46,47], and anti-HIV [48] treatments.…”

“…The replacement of uracil by thiouracils in m-RNA can lead to misrecognition and results in mutation [37]. Interestingly, the substitution of oxygen by sulfur and further methyl-substitution of uracil results in modified nucleobases that have found use in many pharmacological applications [34,[38][39][40][41][42][43][44][45][46][47][48][49][50][51]. 2-Thiouracil and 4-thiouracil are well known for their use in antithyroid, anticancer [34,38,39], and heart disease treatments [40,41].…”

Sulfur Analogs of Pyrimidine Bases: Synthesis of 2‐Alkylthio‐ and 4‐Alkylthio‐5‐bromouracils and In Silico Evaluation of Their Biological Activity

“…For all synthesized compounds (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20), their biological activity spectra were predicted using PASS [19], [20], and the types of activities with the highest probability (focal activities) for particular compounds were selected. The values obtained for representative compounds (the ones with n-decyl group were chosen) are presented in Table 4 It should be noted that the results for the other alkyl groups were very similar.…”

“…The compounds studied, which have 6-methyl substituent, that is, 2-alkylthio and 4-alkylthio-5-bromo-6-methyluracils, are expected to act as potent leukopoiesis stimulants. It ought to be pointed out that the group of compounds (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20) comprises also potential antineoplastic and antiulcerative agents as well as various enzyme inhibitors.…”

Quantiative structure-activity relationship analysis of 1-[(2-Hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT) analogues with the use of random forest

“…This RT within the human immunodeficiency virus type 1 (H IV -1) is responsible for making a copy of the viral RNA into a complementary DNA as the virus enters the host cell. [1][2][3]. In today, one of the most well-known RT inhibitors is the 1-[(2-Hydroxyethoxy )methy 1]-6-(pheny Ithio )thymine (H EPT) which have proven to inhibit HIV-1's RT at a nanomolar concentration.…”